4847081 Synthetic bovine parainfluenza viral proteins

PATENT ABSTRACTS hibits the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication. Longer peptides containing the foregoing pentapeptide sequence. are more potent inhibitors.

48451% MODIFIED INTERFERON GAMMAS

Described are modified human gamma interferons, genes coding for their synthesis and plasmids containing and capable of expressing these genes.

PRES GENE CODED PEPTIDE HEPATITIS B IMMUNOGENS, VACCINES, DIAGNOSTICS, AND SYNTHETIC LIPIDE VESICLE CARRIERS Alexander R Neurath, Stephen B Kent assigned to New York Blood Center Inc; California Institute of Technolo

4845197 MONOCLONAL ANTIBODIES AND METHODS FOR FUNGAL PATHOGEN DETECTION M Maybroda, assigned to

A conjugate comprising a vinca moiety convalently linked at the 4position via a group of the formula -OCOXCO- where X represents a single chemical bond or an optionally substituted Cl10 chain, to an immunoglobulin or an immunoglobulin fragment. The conjugates are useful in the treatment of cancer.

4847080

Graham Cowling, Oxford, United Kingdom assigned to G D Searle & Co

Frank Petersen, Adrianna Grothaus, Sally Miller Diagnostics Associates

607

Gary Agri-

This invention provides monoclonal antibodies useful for the detection of Phythiaceae infection of plants. Hybridoma producing the antibodies as well as materials and kits for carrying out the detection of the organisms are also disclosed.

4845198 HYBRIDOMA ANTIBODY WHICH BINDS IL-2 RECEPTOR

4847081 SYNTHETIC BOVINE PARAINFLUENZA VIRAL PROTEINS John M Rice assigned to W R Grace & Co Corm A method is disclosed for constructing a synthetic aene for the nroduction of a viral nrotein or pot%on thereof. The method is useful for genes found on minus-strand RNA viral genomes, such as those of rhabdoviruses or paramyxoviruses. The protein or a p_ortion thereof prepared by expression of the synthetic gene in a suitable host may be used for vaccine or diagnostic purposes.

David Urdal, Carl March, Steven Dower assigned to Immunex Corporation A monoclonal antibody which specifically binds to the human IL-2 receptor, and a hybridoma which produces the antibody; are disclosed.

4845200 IMMUNOGLOBULIN CONJUGATES George Cullinan, George Rowland, Robin Simmonds assigned to Lilly Industries Limited

4847244 TREATMENT OF HUMAN VIRAL INFECTIONS Janet L Rideout, David Barry, Sandra N Lehrman, Clair Martha H St, Phillip A Furman assigned to Burroughs Wellcome Co Treatments of AIDS or humans carrying or infected with the AIDS virus or having antibodies