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4853249 Method of preparing sustained-release pharmaceutical preparation
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New Patents
glycerol, alkane diol or polyol molecules; and fumaric acid derivatives of the forumla See Patent for Chemical Structure (IX) wherein n is an interger from 30 to 260, R3 is a hydrogen atom or a C1-C3 alkyl group, R4 is one of the R3 groups and n is the number of molecule repetitions, processes for their production and compositions containing same are described. These compounds are useful as drugs for the treatment of cryptogenically-caused diseases and have antisporiatic as well as antimicrobial action.
plays a role in the hemostatic system and, therefore, may be used as an agent for regulation of hemostasis. Further, the invention relates to a process for preparing Tetranectin in which Tetranectin is isolated e.g. from blood or blood fractions, cells or genetically engineered organisms. Finally the invention relates to antiserum or antibodies against Tetranectin, to immunological detection and assay methods wherein said antiserum or antibodies are used as immunological reagent, and to pharmaceutical compositions containing Tetranectin or antibodies against Tetranectin.
4851523 CYCLOPENTYL ETHERS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION Eric W Collington, Harry Finch, Knebworth, United Kingdom assigned to Glaxo Group Limited Compounds of the general formula (1) See Patent for Chemical Structure (1) in which n is 1 or 2; m is 2-5 and X is -CH double bondCH- or CH2-CH2-; or m is 1-4 and X is -CH double bondC double bondCH-; R1 is phenyl, substituted phenyl or naphthyl; Y is substituted or unsubstituted 3-phenoxy-2-hydroxypropyl. These compounds inhibit gastric acid secretion and provide gastrointestinal cytoprotection, and may be formulated for use in the treatment of ulcers.
4853220 PROTEIN ISOLATED FROM BLOOD, PROCESS FOR PREPARING SAID PROTEIN, AANTIBODIES AGAINST SAID NEW PROTEIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID PROTEIN OR SAID ANTIBODIES Inge Clemmensen, Corneli Kluft, Farum, Denmark assigned to Nederlandse Centrale Organisatie Voor Toegerastnatuurwete Nschappelijk Onderzoek The invention relates to Tetranectin, a new protein isolated from blood. Its structure comprises four polypeptide chains having the formula shown in the attached drawing. Tetranectin
4853230 PHARMACEUTICAL FORMULATIONS OF ACID LABILE SUBSTANCES FOR ORAL USE Kurt Lovgren, Ake Pilbrant, Mitsuru Yasumura, Satoshi Morigaki, Minoru Oda, Naohiro Ohishi, Msweded assigned to Aktiebolaget Hassle Pharmaceutical preparation containing an acid labile compound together with an alkaline reacting compound or an alkaline salt of an acid labile compound optionally together with an alkaline compound as the core material, one or more subcoating layers comprising inert reacting compounds which are soluble or rapidly disintegrating in water, or polymeric, water soluble filmforming compounds, optionally containing pH-buffering alkaline compounds and an enteric coating as well as a process for the preparation thereof and the use in the treatment of gastrointestinal diseases.
4853249 METHOD OF PREPARING SUSTAINED-RELEASE PHARMACEUTICAL PREPARATION Yasuji Takashima, Ikuo Koyama, Tooru Maki, Katsu Nakamori, Ageo, Japan assigned to Taisho Pharmaceutical Co Ltd A method of preparing a sustained-release pharmaceutical preparation, which comprises applying a solution of a binder in water or an alcohol and a fine powder of a hydrophobic solid material which does not easily dissolve within
New Patents the stomach and intestines to the surface of solid particles containing a drug while the solid particles are being tumbled, thereby to coat the solid particles with the binder and the hydrophobic solid material.
4853386 N6-DISUBSTITUTED PURINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USEFUL FOR TREATING ALLERGIC DISEASES, BRONCHOSPASTIC AND BRONCHOCONSTRICTORY CONDITIONS Walter-Gunar Friebe, Otto-Henning Wilhelms, Mannheim, Federal Republic Of Germany assigned to Boehftnger Mannheim GmbH The present invention provides N6disubstituted purine derivatives of the general formula: See Patent for Chemical Structure (I) wherein R1 and R4 are the same or different and each represents a hydrogen or halogen atom or an -NR6R7 group, R2 and R3 are the same or different and each represents a C I-C6 alkyl radical, a C2-C6 alkenyl radical, a C3-C7 cycloalkyl radical, a phenalkyl radical containing up to 4 carbon atoms in the alkyl moiety, which can be straight-chained or branched, the phenyl moiety of which can be substituted one or more times by halogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio or trifluoromethyl; a furylmethyl or furylethyl radical, a thiophenemethyl or thiopheneethyl radical, a pyridylmethyl or pyridylethyl radical optionally substituted by a C1-C4 alkyl radical, an indanyl radical or a tetrahydronaphthyl radical, R5 is a hydrogen atom, a tetrahydrofuranyl or tetrahydropyranyl radical or a C 1-C 10 radical which is optionally substituted one or more times by hydroxyl, C1-C6 alkanoyloxy, C1-C6 alkoxycarbonyl, C2-C6 carboxyalkanoyloxy, C2-C6 hydroxyalkoxy, C3-c6 dihydroxyalkoxy, carboxyl, cyano or 1H-tetrazol-5-yl radical, R6 and R7 are the same or different and each represents a hydrogen atom or a CI-C6 alkyl radical or together represent a C2-C5 alkylene radical optionally interrupted by oxygen, sulphur or an NR8 group and R8 is a hydrogen atom or a C1C6 alkyl radical; as well as the pharmacologically acceptable salts thereof.
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4853405 CONDENSED PYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USE Gianfederico Doria, Anna M Isetta, Mario Ferraft, Domenico Trizio, Milan, Italy assigned to Farmitalia Carlo Erba S r 1 The invention relates to compounds having the general formula (I) See Patent for Chemical Structure (I) and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.
4855142 PHARMACEUTICAL PLASTER Peter Fankhauser~ Joel Sinnreich, Rolf Dobmeier, Ettingen, Switzerland assigned to CibaGeigy Corporation The invention relates to a pharmaceutical plaster that adheres to the mucosa, consisting of two discrete layers that adhere well to one another, which may contain pharmaceutical active ingredients suitable for topical application or for systemic treatment. It is distinguished by outstanding long-lasting adhesion to the mucosa and is very pleasant in use, especially in the mouth as an oral plaster.
4855143 METHOD OF PREPARING CONTROLLED LONG-ACTING PHARMACEUTICAL FORMULATIONS IN UNIT DOSAGE FORM HAVING UNIFORM AND COMPARABLE BIOAVAILABILITY CHARACTERISTICS Hans Lowey A method of preparing a multiplicity of controlled, long-acting release pharmaceutical tablets, each containing a therapeutic agent and a cellulosic ether carrier base material is shown.
New Patents
glycerol, alkane diol or polyol molecules; and fumaric acid derivatives of the forumla See Patent for Chemical Structure (IX) wherein n is an interger from 30 to 260, R3 is a hydrogen atom or a C1-C3 alkyl group, R4 is one of the R3 groups and n is the number of molecule repetitions, processes for their production and compositions containing same are described. These compounds are useful as drugs for the treatment of cryptogenically-caused diseases and have antisporiatic as well as antimicrobial action.
plays a role in the hemostatic system and, therefore, may be used as an agent for regulation of hemostasis. Further, the invention relates to a process for preparing Tetranectin in which Tetranectin is isolated e.g. from blood or blood fractions, cells or genetically engineered organisms. Finally the invention relates to antiserum or antibodies against Tetranectin, to immunological detection and assay methods wherein said antiserum or antibodies are used as immunological reagent, and to pharmaceutical compositions containing Tetranectin or antibodies against Tetranectin.
4851523 CYCLOPENTYL ETHERS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION Eric W Collington, Harry Finch, Knebworth, United Kingdom assigned to Glaxo Group Limited Compounds of the general formula (1) See Patent for Chemical Structure (1) in which n is 1 or 2; m is 2-5 and X is -CH double bondCH- or CH2-CH2-; or m is 1-4 and X is -CH double bondC double bondCH-; R1 is phenyl, substituted phenyl or naphthyl; Y is substituted or unsubstituted 3-phenoxy-2-hydroxypropyl. These compounds inhibit gastric acid secretion and provide gastrointestinal cytoprotection, and may be formulated for use in the treatment of ulcers.
4853220 PROTEIN ISOLATED FROM BLOOD, PROCESS FOR PREPARING SAID PROTEIN, AANTIBODIES AGAINST SAID NEW PROTEIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID PROTEIN OR SAID ANTIBODIES Inge Clemmensen, Corneli Kluft, Farum, Denmark assigned to Nederlandse Centrale Organisatie Voor Toegerastnatuurwete Nschappelijk Onderzoek The invention relates to Tetranectin, a new protein isolated from blood. Its structure comprises four polypeptide chains having the formula shown in the attached drawing. Tetranectin
4853230 PHARMACEUTICAL FORMULATIONS OF ACID LABILE SUBSTANCES FOR ORAL USE Kurt Lovgren, Ake Pilbrant, Mitsuru Yasumura, Satoshi Morigaki, Minoru Oda, Naohiro Ohishi, Msweded assigned to Aktiebolaget Hassle Pharmaceutical preparation containing an acid labile compound together with an alkaline reacting compound or an alkaline salt of an acid labile compound optionally together with an alkaline compound as the core material, one or more subcoating layers comprising inert reacting compounds which are soluble or rapidly disintegrating in water, or polymeric, water soluble filmforming compounds, optionally containing pH-buffering alkaline compounds and an enteric coating as well as a process for the preparation thereof and the use in the treatment of gastrointestinal diseases.
4853249 METHOD OF PREPARING SUSTAINED-RELEASE PHARMACEUTICAL PREPARATION Yasuji Takashima, Ikuo Koyama, Tooru Maki, Katsu Nakamori, Ageo, Japan assigned to Taisho Pharmaceutical Co Ltd A method of preparing a sustained-release pharmaceutical preparation, which comprises applying a solution of a binder in water or an alcohol and a fine powder of a hydrophobic solid material which does not easily dissolve within
New Patents the stomach and intestines to the surface of solid particles containing a drug while the solid particles are being tumbled, thereby to coat the solid particles with the binder and the hydrophobic solid material.
4853386 N6-DISUBSTITUTED PURINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USEFUL FOR TREATING ALLERGIC DISEASES, BRONCHOSPASTIC AND BRONCHOCONSTRICTORY CONDITIONS Walter-Gunar Friebe, Otto-Henning Wilhelms, Mannheim, Federal Republic Of Germany assigned to Boehftnger Mannheim GmbH The present invention provides N6disubstituted purine derivatives of the general formula: See Patent for Chemical Structure (I) wherein R1 and R4 are the same or different and each represents a hydrogen or halogen atom or an -NR6R7 group, R2 and R3 are the same or different and each represents a C I-C6 alkyl radical, a C2-C6 alkenyl radical, a C3-C7 cycloalkyl radical, a phenalkyl radical containing up to 4 carbon atoms in the alkyl moiety, which can be straight-chained or branched, the phenyl moiety of which can be substituted one or more times by halogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio or trifluoromethyl; a furylmethyl or furylethyl radical, a thiophenemethyl or thiopheneethyl radical, a pyridylmethyl or pyridylethyl radical optionally substituted by a C1-C4 alkyl radical, an indanyl radical or a tetrahydronaphthyl radical, R5 is a hydrogen atom, a tetrahydrofuranyl or tetrahydropyranyl radical or a C 1-C 10 radical which is optionally substituted one or more times by hydroxyl, C1-C6 alkanoyloxy, C1-C6 alkoxycarbonyl, C2-C6 carboxyalkanoyloxy, C2-C6 hydroxyalkoxy, C3-c6 dihydroxyalkoxy, carboxyl, cyano or 1H-tetrazol-5-yl radical, R6 and R7 are the same or different and each represents a hydrogen atom or a CI-C6 alkyl radical or together represent a C2-C5 alkylene radical optionally interrupted by oxygen, sulphur or an NR8 group and R8 is a hydrogen atom or a C1C6 alkyl radical; as well as the pharmacologically acceptable salts thereof.
xvii
4853405 CONDENSED PYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USE Gianfederico Doria, Anna M Isetta, Mario Ferraft, Domenico Trizio, Milan, Italy assigned to Farmitalia Carlo Erba S r 1 The invention relates to compounds having the general formula (I) See Patent for Chemical Structure (I) and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.
4855142 PHARMACEUTICAL PLASTER Peter Fankhauser~ Joel Sinnreich, Rolf Dobmeier, Ettingen, Switzerland assigned to CibaGeigy Corporation The invention relates to a pharmaceutical plaster that adheres to the mucosa, consisting of two discrete layers that adhere well to one another, which may contain pharmaceutical active ingredients suitable for topical application or for systemic treatment. It is distinguished by outstanding long-lasting adhesion to the mucosa and is very pleasant in use, especially in the mouth as an oral plaster.
4855143 METHOD OF PREPARING CONTROLLED LONG-ACTING PHARMACEUTICAL FORMULATIONS IN UNIT DOSAGE FORM HAVING UNIFORM AND COMPARABLE BIOAVAILABILITY CHARACTERISTICS Hans Lowey A method of preparing a multiplicity of controlled, long-acting release pharmaceutical tablets, each containing a therapeutic agent and a cellulosic ether carrier base material is shown.