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4859587 Recombinant herpes simplex viruses, vaccines and methods
PATENT ABSTRACTS rapidly from the circulation. Use of such modified antibodies and antibody conjugates for imaging and therapy of tumors and infectious lesions is advantageous when the antibodies are administered by a regional route, or when intravenous administration is accompanied by injection of a competitive hepatic lectin binding inhibitor to control the rate of clearance and optimize uptake by the target tissues, 4859450 METHOD OF NMR IMAGING USING ANTIBODY TO CARDIAC MYOSIN Mark Goldman assigned to The General Hospital Corporation An in vivo N M R imaging method comprising administering to a human patient an N M R contrast agent comprising a specific affinity orgarlic substituent complexed with a paramagnetic substance and subjecting the patient to N M R imaging. 4859464 METHOD FOR THE PURIFICATION OF PARASITE ANTIGENIC FACTORS Lawrence E D'Antonio A method for the solubilization and recovery of insoluble parasite protective antigenic factors associated with parasite material comprising solubilizing the antigenic factors with a. nonionic detergent and separating the solubilized material from undispersed residual material. The purified protective antigenic factors are useful as vaccines, particularly against malaria, and as diagnostic agents. 4859465 VACCINE CAPABLE OF ELICITING MULTIVALENT ANTIBODIES William J Rutter assigned to The Regents of the University of California The present invention discloses a D N A transfer vector comprising two or more deoxynucleotide sequences coding for different antigenic materials linked together in phase with one another. The present invention further discloses
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the expression of said deoxynucleotide sequences either directly or as a fusion protein with the product of a procaryotic gene. The resulting expression product is then either a fusion protein comprising two or more antigenic materials or a fusion protein comprising a part of a procaryotic protein and two or more antigenic materials. These fusion products are capable of eliciting the formation of multivalent antibodies which are cross-reactive with any and all of the native antigenic material. A vaccine is also described utilizing these fusion products.
4859587 RECOMBINANT HERPES SIMPLEX VIRUSES, VACCINES AND METHODS Bernard Roizman assigned to Institut Merieux Recombinant herpes viruses useful as effective ingredients in vaccines against both virulent HSV-I and HSV-2 are disclosed. Methods of preparing the recombinant viruses, vaccines incorporating the viruses, and methods of immunizing a human host by inoculation with the vaccines are also disclosed. The genomes of the recombinant viruses each comprise a mutant of the HSV-1 genome from which a portion thereof responsible for neurovirulence yet nonessential for growth is deleted. A gene from the HSV-2 genome responsible for coding an immunityinducing glycoprotein is inserted in the mutant genome between the end points of deletion therein. 4859595 METHOD FOR PREPARING RABBIT MONOCLONAL ANTIBODIES, THE CELL LINES USED THEREIN AND THE ANTIBODIES PRODUCED THEREBY Arthur D Strosberg, Jean-Gerard Guillet, 75105 Paris, France A new continuous rabbit cell line, designated TP-3, and variants thereof, which are hypoxyxanthine guanine-phosphoribosyl transferase deficient, hypoxy xanthine aminopterine thymidine sensitive, fast growing and nonantibody producing, and the methods for preparing the TP-3 cell line. Also, rabbit-rabbit
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the expression of said deoxynucleotide sequences either directly or as a fusion protein with the product of a procaryotic gene. The resulting expression product is then either a fusion protein comprising two or more antigenic materials or a fusion protein comprising a part of a procaryotic protein and two or more antigenic materials. These fusion products are capable of eliciting the formation of multivalent antibodies which are cross-reactive with any and all of the native antigenic material. A vaccine is also described utilizing these fusion products.
4859587 RECOMBINANT HERPES SIMPLEX VIRUSES, VACCINES AND METHODS Bernard Roizman assigned to Institut Merieux Recombinant herpes viruses useful as effective ingredients in vaccines against both virulent HSV-I and HSV-2 are disclosed. Methods of preparing the recombinant viruses, vaccines incorporating the viruses, and methods of immunizing a human host by inoculation with the vaccines are also disclosed. The genomes of the recombinant viruses each comprise a mutant of the HSV-1 genome from which a portion thereof responsible for neurovirulence yet nonessential for growth is deleted. A gene from the HSV-2 genome responsible for coding an immunityinducing glycoprotein is inserted in the mutant genome between the end points of deletion therein. 4859595 METHOD FOR PREPARING RABBIT MONOCLONAL ANTIBODIES, THE CELL LINES USED THEREIN AND THE ANTIBODIES PRODUCED THEREBY Arthur D Strosberg, Jean-Gerard Guillet, 75105 Paris, France A new continuous rabbit cell line, designated TP-3, and variants thereof, which are hypoxyxanthine guanine-phosphoribosyl transferase deficient, hypoxy xanthine aminopterine thymidine sensitive, fast growing and nonantibody producing, and the methods for preparing the TP-3 cell line. Also, rabbit-rabbit