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4863854 Monoclonal antibodies to mucin-like human differentiation antigens
PATENT ABSTRACTS
462
4863851 MONOCLONAL ANTIBODY PROSTATE SECRETORY PROTEIN
TO
cancerous state. Compositions and methods based on the disclosed peptides for detection and treatment of cancer and other proliferative diseases and for cell or tissue growth associated treatment, e.g., wound healing, ulcer therapy and bone loss are also described.
Robert McEwan, Donald Carter assigned to The Upjohn Company Provided are hybridomas for producing monoclonal antibodies against human prostate secretory protein (PSP15), anti-PSP15 monoclonal antibodies, fragments and derivatives thereof, and methods for their use. The antibodies are monospecific, bind to protein A and are of the IgM class of immunoglobulins. The monoclonal antibodies are useful as basic diagnostics for detecting human prostate cancer cells, 4863854 MONOCLONAL ANTIBODIES TO MUCIN-LIKE HUMAN DIFFERENTIATION ANTIGENS M Jules Mattes, John Lewis, Lloyd Old, Kenneth O Floyd, Katherin Look assigned to SloanKettering Institute for Cancer Research Three new monoclonal antibodies, MU78, MT334, and MQ49, and the hybridoma cell lines producing these, are disclosed. The antibodies specifically bind to mucin-like antigens with distribution over various carcinomas.
4863955 SCYTOPHYCINS Richard Moore, Eiich Furusawa, Ted R Norton, Gregory M L Patterson, Jon S Mynderse assigned to Eli Lilly and Company; University of Hawa Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (seytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided. 4864019 T O I N H I B I N AND CONJUGATES PRODUCED
ANTIBODIES 4863899 BIOLOGICALLY ACTIVE POLYPEPTIDES
THEREFROM Wylie W Vale, Jean E F Rivier, Joachi Spiess assigned to The Salk Institute for Biological Studies
George J Todaro Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides, which exhibit cell growth promoting properties are disclosed, as well as a process for isolating the TGF polypeptides from both human and murine cell lines in hom6geneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligipeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certairk cell lines into a
A 32,000-Dalton protein with inhibin activity is isolated from porcine follicular fluid which is composed of two chains having molecular weights of about 18,000 and about 14,000 Daltons, which are bound together by disulfide bonding. Microsequencing revealed the NH2terminal portion of the 18 kD chain to be SerThr Ala-Pro-Leu-Pro Trp-Pro-Trp-Ser-Pro-Ala Ala-Leu-Arg-Leu-Leu-GIn-Ar g-Pro-Pro-GluGlu-Pro-Ala-Val and of the 14 kD chain to be Gly-Leu-Glu-Cys with the next 21 residues believed to be Asp-Gly-Ser-His-Asn-Leu-Asp Ser-Arg-GIn-Gln-Phe-Phe Ile-Asp Phe-ArgLeu-Il e-G y-Trp. This 32 kD protein specifically inhibits basal secretion of FSH, but not of LH.
462
4863851 MONOCLONAL ANTIBODY PROSTATE SECRETORY PROTEIN
TO
cancerous state. Compositions and methods based on the disclosed peptides for detection and treatment of cancer and other proliferative diseases and for cell or tissue growth associated treatment, e.g., wound healing, ulcer therapy and bone loss are also described.
Robert McEwan, Donald Carter assigned to The Upjohn Company Provided are hybridomas for producing monoclonal antibodies against human prostate secretory protein (PSP15), anti-PSP15 monoclonal antibodies, fragments and derivatives thereof, and methods for their use. The antibodies are monospecific, bind to protein A and are of the IgM class of immunoglobulins. The monoclonal antibodies are useful as basic diagnostics for detecting human prostate cancer cells, 4863854 MONOCLONAL ANTIBODIES TO MUCIN-LIKE HUMAN DIFFERENTIATION ANTIGENS M Jules Mattes, John Lewis, Lloyd Old, Kenneth O Floyd, Katherin Look assigned to SloanKettering Institute for Cancer Research Three new monoclonal antibodies, MU78, MT334, and MQ49, and the hybridoma cell lines producing these, are disclosed. The antibodies specifically bind to mucin-like antigens with distribution over various carcinomas.
4863955 SCYTOPHYCINS Richard Moore, Eiich Furusawa, Ted R Norton, Gregory M L Patterson, Jon S Mynderse assigned to Eli Lilly and Company; University of Hawa Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (seytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided. 4864019 T O I N H I B I N AND CONJUGATES PRODUCED
ANTIBODIES 4863899 BIOLOGICALLY ACTIVE POLYPEPTIDES
THEREFROM Wylie W Vale, Jean E F Rivier, Joachi Spiess assigned to The Salk Institute for Biological Studies
George J Todaro Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides, which exhibit cell growth promoting properties are disclosed, as well as a process for isolating the TGF polypeptides from both human and murine cell lines in hom6geneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligipeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certairk cell lines into a
A 32,000-Dalton protein with inhibin activity is isolated from porcine follicular fluid which is composed of two chains having molecular weights of about 18,000 and about 14,000 Daltons, which are bound together by disulfide bonding. Microsequencing revealed the NH2terminal portion of the 18 kD chain to be SerThr Ala-Pro-Leu-Pro Trp-Pro-Trp-Ser-Pro-Ala Ala-Leu-Arg-Leu-Leu-GIn-Ar g-Pro-Pro-GluGlu-Pro-Ala-Val and of the 14 kD chain to be Gly-Leu-Glu-Cys with the next 21 residues believed to be Asp-Gly-Ser-His-Asn-Leu-Asp Ser-Arg-GIn-Gln-Phe-Phe Ile-Asp Phe-ArgLeu-Il e-G y-Trp. This 32 kD protein specifically inhibits basal secretion of FSH, but not of LH.