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488169 Bordetella bronchiseptica vaccine
New Patents
4888169 BORDETELLA BRONCHISEPTICA VACCINE Albert Brown, Joseph C Frantz, Richard H Peetz assigned to Norden Laboratories Inc A vaccine for protecting canines against infection by Bordetella bronchiseptica is prepared by inactivating whole cells with glutaraldehyde.
4888170 VACCINES OBTAINED FROM ANTIGENIC GENE PRODUCTS OF RECOMBINANT GENES Roy Curtiss assigned to Research Corporation This invention relates to a vaccine for the immunization of a vertebrate, comprising: an avirulent derivative of a pathogenic microbe that expresses a recombinant gene derived from a pathogen of said vertebrate it being provided that said avirulent microbe does not normally exchange genetic material with said pathogen, to produce an antigen capable of inducing an immune response in said vertebrate against said pathogen.
4888276 METHOD AND COMPOSITION FOR THE DIAGNOSIS OF LYME DISEASE Charles E Shelburne assigned to Minnesota Mining and Manufacturing Company A reliable, rapid, inexpensive and noninvasive method is provided for the diagnosis of Lyme disease by the detection of antigens of the spirochete responsible for that disease, Borrelia burgdorferi, in the urine of an affected individual.
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4888279 NOVEL IMMUNOSORBENT ASSAYS EMPLOYING ANTIBIOTIC KEYING AGENTS Allen R Zeiger assigned to Thomas Jefferson University New immunosorbent enzyme assays are provided employing antibiotic keying agents for binding a molecular species to be detected to a test surface followed by binding of an antibody specific for the species and detection of the antibody-species binding. In accordance with preferred embodiments, soluble peptidoglycan is assayed in a fluid binding it to a test surface with vancomycin, reacting the bound material with a peptidoglycan specific antibody, and measuring the extent of the antibody reaction. Assessment of bodily fluids and fermenation broths for the presence of certain kinds of antibiotics is one object of this invention. Assessment of sera for the presence of antibodies that have specificity for soluble peptidoglycans is another object of this invention. Assessment of bodily states in mammals is another object of the invention.
4888284 DIPEPTIDASE, ITS ISOLATION FROM LACTIC ACID BACTERIA, ANTIBODIES AGAINST THE DIPEPTIDASE, THE USE OF THE DIPEPTIDASE AND OF THE ANTIBODIES AGAINST IT Willem N Konings, Aart van Boven, Haren, Netherlands assigned to Rijksuniversiteit te Groningen This invention relates to dipeptidase of lactic acid bacteria in isolated form, characterized by a molecular weight of 55 kD+/-5 kD; an isoelectric point of 4.4+/-0.4; a substrate range including the dipeptides leu-leu, leu-met, leu-val, leu-gly, val-leu, phe-leu and ala-ala, but not the dipeptides his-leu, gamma-glu-leu, gly-leu, alpha-glu-ala and peptides of 3 or more amino acid residues; and a hydrolyzing activity with a temperature optimum at 50 degrees C.+/-10
4888169 BORDETELLA BRONCHISEPTICA VACCINE Albert Brown, Joseph C Frantz, Richard H Peetz assigned to Norden Laboratories Inc A vaccine for protecting canines against infection by Bordetella bronchiseptica is prepared by inactivating whole cells with glutaraldehyde.
4888170 VACCINES OBTAINED FROM ANTIGENIC GENE PRODUCTS OF RECOMBINANT GENES Roy Curtiss assigned to Research Corporation This invention relates to a vaccine for the immunization of a vertebrate, comprising: an avirulent derivative of a pathogenic microbe that expresses a recombinant gene derived from a pathogen of said vertebrate it being provided that said avirulent microbe does not normally exchange genetic material with said pathogen, to produce an antigen capable of inducing an immune response in said vertebrate against said pathogen.
4888276 METHOD AND COMPOSITION FOR THE DIAGNOSIS OF LYME DISEASE Charles E Shelburne assigned to Minnesota Mining and Manufacturing Company A reliable, rapid, inexpensive and noninvasive method is provided for the diagnosis of Lyme disease by the detection of antigens of the spirochete responsible for that disease, Borrelia burgdorferi, in the urine of an affected individual.
xxxi
4888279 NOVEL IMMUNOSORBENT ASSAYS EMPLOYING ANTIBIOTIC KEYING AGENTS Allen R Zeiger assigned to Thomas Jefferson University New immunosorbent enzyme assays are provided employing antibiotic keying agents for binding a molecular species to be detected to a test surface followed by binding of an antibody specific for the species and detection of the antibody-species binding. In accordance with preferred embodiments, soluble peptidoglycan is assayed in a fluid binding it to a test surface with vancomycin, reacting the bound material with a peptidoglycan specific antibody, and measuring the extent of the antibody reaction. Assessment of bodily fluids and fermenation broths for the presence of certain kinds of antibiotics is one object of this invention. Assessment of sera for the presence of antibodies that have specificity for soluble peptidoglycans is another object of this invention. Assessment of bodily states in mammals is another object of the invention.
4888284 DIPEPTIDASE, ITS ISOLATION FROM LACTIC ACID BACTERIA, ANTIBODIES AGAINST THE DIPEPTIDASE, THE USE OF THE DIPEPTIDASE AND OF THE ANTIBODIES AGAINST IT Willem N Konings, Aart van Boven, Haren, Netherlands assigned to Rijksuniversiteit te Groningen This invention relates to dipeptidase of lactic acid bacteria in isolated form, characterized by a molecular weight of 55 kD+/-5 kD; an isoelectric point of 4.4+/-0.4; a substrate range including the dipeptides leu-leu, leu-met, leu-val, leu-gly, val-leu, phe-leu and ala-ala, but not the dipeptides his-leu, gamma-glu-leu, gly-leu, alpha-glu-ala and peptides of 3 or more amino acid residues; and a hydrolyzing activity with a temperature optimum at 50 degrees C.+/-10