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4923799 T cell specific CDNA clone
New Patents
vii
Phytolaccin americana using the technique of immunoaffinity chromatography. Phytolaccin proteins were purified to apparent homogeneity in a rapid and efficient chromatographic procedure utilizing immobilized monospecific antiphytolaccin antibodies. Immunoaffinitypurified phytolaccinl and phytolaccin2 were determined by denaturing gel electrophoresis to be of approximately 25,600 and 28,400 daltons, respectively. The two immunoaffinity-purified proteins were equally potent inhibitors of eukaryotic cell-free protein biosynthesis and exhibited mostly similar high-order UV derivative spectra. Antibodies against phytolaccinl and phytolaccin2 did not cross-react with the heterologous antigen, indicating a structural dissimilarity between the two phytolaccin proteins.
lower chamber, particularly useful in an immunoassay. The filter and device are improved in that the membrane comprising the filter is overcoated with at least one water-soluble polymer of a type, a molecular weight, and at a dry-solids coverage effective to create for that membrane an induction time at room temperature of at least about 30 seconds and no greater than about 300 seconds, for a liquid head of pressure of about 6 mm of water.
4921858
Eric LeMoine, Eric S Bean, Morton A Vodian assigned to Synbiotics Corporation
7-DEAZAGUANINES AS IMMUNOMODULATORS Thomas Malone, Jagadish C Sircar assigned to Warner-Lambert Company The present invention is various 7deazaguanines having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
4923798 SALIVA TEST FOR FELINE LEUKEMIA VIRUS
An immunoassay method and apparatus for diagnosing FeLV-induced, persistent viremia is provided comprising combining a feline saliva sample conveniently obtained with a specially designed probe, with anti-p27 antibodies and detecting complex formation as indicative of the viremia. Preferably, the antibodies are bound to the probe for complex formation.
4923799 4921859 T CELL PURINE
SPECIFIC
CDNA
CLONE
DERIVATIVES
Jagadish C Sircar, Charles F Schwender, Mark J Suto assigned to Warner-Lambert Company Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
4923680 TEST DEVICE CONTAINING AN IMMUNOASSAY FILTER WITH A FLOW-DELAYING POLYMER Roger W Nelson assigned to Eastman Kodak Company There is disclosed a filter and a device positioning the filter between an upper and a
Tak W Mak, Toronto, Canada assigned to The Ontario Cancer Institute The invention provides a nucleic acid having a sequence which encodes a polypeptide that is at least part of a T cell antigen receptor. This encoded sequence is about 936 nucleotides in length and preferably is a human T cell antigen receptor. The nucleic acid sequence of one embodiment of the invention is shown in FIG. 3. The nucleic acid sequence may be used as a probe to determine whether an unknown cell, e.g., a tumor cell, is a T cell. Polypeptides encoded by the nucleic acid sequence include about 312 amino acids and are at least part of a T cell antigen receptor. They include at least one sequence which over 21 contiguous amino acids has greater than about 35% homology with mouse and h u m a n immunoglobin lambda light chains. Antibody to the polypeptide may be prepared and used to identify T cell antigen receptor and to determine whether an unknown cell, e.g., a tumor cell, is a T cell.
vii
Phytolaccin americana using the technique of immunoaffinity chromatography. Phytolaccin proteins were purified to apparent homogeneity in a rapid and efficient chromatographic procedure utilizing immobilized monospecific antiphytolaccin antibodies. Immunoaffinitypurified phytolaccinl and phytolaccin2 were determined by denaturing gel electrophoresis to be of approximately 25,600 and 28,400 daltons, respectively. The two immunoaffinity-purified proteins were equally potent inhibitors of eukaryotic cell-free protein biosynthesis and exhibited mostly similar high-order UV derivative spectra. Antibodies against phytolaccinl and phytolaccin2 did not cross-react with the heterologous antigen, indicating a structural dissimilarity between the two phytolaccin proteins.
lower chamber, particularly useful in an immunoassay. The filter and device are improved in that the membrane comprising the filter is overcoated with at least one water-soluble polymer of a type, a molecular weight, and at a dry-solids coverage effective to create for that membrane an induction time at room temperature of at least about 30 seconds and no greater than about 300 seconds, for a liquid head of pressure of about 6 mm of water.
4921858
Eric LeMoine, Eric S Bean, Morton A Vodian assigned to Synbiotics Corporation
7-DEAZAGUANINES AS IMMUNOMODULATORS Thomas Malone, Jagadish C Sircar assigned to Warner-Lambert Company The present invention is various 7deazaguanines having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
4923798 SALIVA TEST FOR FELINE LEUKEMIA VIRUS
An immunoassay method and apparatus for diagnosing FeLV-induced, persistent viremia is provided comprising combining a feline saliva sample conveniently obtained with a specially designed probe, with anti-p27 antibodies and detecting complex formation as indicative of the viremia. Preferably, the antibodies are bound to the probe for complex formation.
4923799 4921859 T CELL PURINE
SPECIFIC
CDNA
CLONE
DERIVATIVES
Jagadish C Sircar, Charles F Schwender, Mark J Suto assigned to Warner-Lambert Company Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
4923680 TEST DEVICE CONTAINING AN IMMUNOASSAY FILTER WITH A FLOW-DELAYING POLYMER Roger W Nelson assigned to Eastman Kodak Company There is disclosed a filter and a device positioning the filter between an upper and a
Tak W Mak, Toronto, Canada assigned to The Ontario Cancer Institute The invention provides a nucleic acid having a sequence which encodes a polypeptide that is at least part of a T cell antigen receptor. This encoded sequence is about 936 nucleotides in length and preferably is a human T cell antigen receptor. The nucleic acid sequence of one embodiment of the invention is shown in FIG. 3. The nucleic acid sequence may be used as a probe to determine whether an unknown cell, e.g., a tumor cell, is a T cell. Polypeptides encoded by the nucleic acid sequence include about 312 amino acids and are at least part of a T cell antigen receptor. They include at least one sequence which over 21 contiguous amino acids has greater than about 35% homology with mouse and h u m a n immunoglobin lambda light chains. Antibody to the polypeptide may be prepared and used to identify T cell antigen receptor and to determine whether an unknown cell, e.g., a tumor cell, is a T cell.