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4956352 Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
New Patents
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4956007
4956352
NITRAMINODIARYL SULFOXIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AND PESTICIDAL COMPOSITIONS CONTAINING THEM
TRICYCLO C O M P O U N D S , A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Janos Kreidl, Peter Turcsanyi, StefkoBela, nee Brill Judit Meszaros, Erika Bogsch, Budapest, Hungary assigned to Richter Gedeon Vegyeszeti Gyor Rt
Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka, Ibaraki, Japan assigned to Fujisawa Pharmaceutical Co Ltd
The invention relates to a new process for the preparation of nitraminodiaryl sulfoxide derivatives of the formula (I), See Patent for Chemical Structure (I) wherein R and RI represent hydrogen or alkyl having from 1 to 6 carbon atoms, and R2 is hydrogen, halogen, alkyl having from I to 6 carbon atoms, alkoxy having from ! to 6 carbon atoms, or phenyl or thiophenyl both optionally substituted by one or more identical or different halogen(s) and/or nitro group(s). The compounds of formula (I) are pharmaceutically active, and are particularly useful in the veterinary therapy as anthelmintics. In addition they show pesticidal, particularly acaricidal, fungicidal and herbicidal properties. The invention relates also to pharmaceutical and pesticidal compositions containing as active ingredient compounds of formula (I). The compounds of formula (I), in which the substituents are as defined, with the proviso that if R2 is hydrogen and the substituent -N(R,RI) is in para-position related to the sulfoxide group, R and RI are other than hydrogen or methyl, are
This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: See Patent for Chemical Structure (I) to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
new.
4956351 ANTIVIRAL PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLODEXTRINS Jean Mesens, Koenraad J L M Andries, Wechelderzande, Belgium assigned to Janssen Pharmaceutica N V frame-543 An antiviral composition for adminisitration to a mammal, in particular, intranasally, for the treatment of the common cold by control of common rhinoviruses. The composition is an inclusion complex of a cyclodextrin, e.g. an alpha-, beta- or gamma-cyciodextrin or derivatives thereof and an antiviral agent.
4956366 SUBSTITUTED THIENOIMIDAZOLE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE THEREOF AS INHIBITORS OF GASTRIC ACID SECRETION, AS GASTROPROTECTIVES AND AS MEDICAMENTS FOR INTESTINAL INFLAMMATIONS Hildegard Nimmesgern, Klaus Weidmann, Hans-Jochen Lang, Robert Rippel, Andreas W Herling, Frankfurt am Main, Federal Republic Of Germany assigned to Hoechst Aktiengesellschaft Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations The invention relates to compounds of the formula See Patent for Chemical Structure (I) in which A represents See Pa, tent for Chemical Structure (a) SRI orR2 (b) R2SR1 (c) T denotes -S-, -SO- or -SO2-, R1 to Rl0, X, Y and Z have the meanings indicated in
ix
4956007
4956352
NITRAMINODIARYL SULFOXIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AND PESTICIDAL COMPOSITIONS CONTAINING THEM
TRICYCLO C O M P O U N D S , A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Janos Kreidl, Peter Turcsanyi, StefkoBela, nee Brill Judit Meszaros, Erika Bogsch, Budapest, Hungary assigned to Richter Gedeon Vegyeszeti Gyor Rt
Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka, Ibaraki, Japan assigned to Fujisawa Pharmaceutical Co Ltd
The invention relates to a new process for the preparation of nitraminodiaryl sulfoxide derivatives of the formula (I), See Patent for Chemical Structure (I) wherein R and RI represent hydrogen or alkyl having from 1 to 6 carbon atoms, and R2 is hydrogen, halogen, alkyl having from I to 6 carbon atoms, alkoxy having from ! to 6 carbon atoms, or phenyl or thiophenyl both optionally substituted by one or more identical or different halogen(s) and/or nitro group(s). The compounds of formula (I) are pharmaceutically active, and are particularly useful in the veterinary therapy as anthelmintics. In addition they show pesticidal, particularly acaricidal, fungicidal and herbicidal properties. The invention relates also to pharmaceutical and pesticidal compositions containing as active ingredient compounds of formula (I). The compounds of formula (I), in which the substituents are as defined, with the proviso that if R2 is hydrogen and the substituent -N(R,RI) is in para-position related to the sulfoxide group, R and RI are other than hydrogen or methyl, are
This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: See Patent for Chemical Structure (I) to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
new.
4956351 ANTIVIRAL PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLODEXTRINS Jean Mesens, Koenraad J L M Andries, Wechelderzande, Belgium assigned to Janssen Pharmaceutica N V frame-543 An antiviral composition for adminisitration to a mammal, in particular, intranasally, for the treatment of the common cold by control of common rhinoviruses. The composition is an inclusion complex of a cyclodextrin, e.g. an alpha-, beta- or gamma-cyciodextrin or derivatives thereof and an antiviral agent.
4956366 SUBSTITUTED THIENOIMIDAZOLE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE THEREOF AS INHIBITORS OF GASTRIC ACID SECRETION, AS GASTROPROTECTIVES AND AS MEDICAMENTS FOR INTESTINAL INFLAMMATIONS Hildegard Nimmesgern, Klaus Weidmann, Hans-Jochen Lang, Robert Rippel, Andreas W Herling, Frankfurt am Main, Federal Republic Of Germany assigned to Hoechst Aktiengesellschaft Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations The invention relates to compounds of the formula See Patent for Chemical Structure (I) in which A represents See Pa, tent for Chemical Structure (a) SRI orR2 (b) R2SR1 (c) T denotes -S-, -SO- or -SO2-, R1 to Rl0, X, Y and Z have the meanings indicated in