- Email: [email protected]
4960716 Monoclonal antibodies specific for 330 kd breast tumor antigen and assay using said monoclonal antibodies
PATENT ABSTRACTS sequences of segments in bovine male-specific D N A and are suitable for sexing bovine embryos at the time of embryo transfer with nearly 100% accuracy.
closed. The invention further comprises recombinant DNA cloning vectors and transformants of the aforementioned DNA.
4960716
4960700 COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND ASSAY OF A MAMMALIAN ENKEPHALINASE Bernard Malfroy-Camine, Peter R Schofield assigned to Genentech Inc DNA isolates coding for enkephalinase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of enkephalinase for use in therapeutic or diagnostic compositions. Enkephalinase assays are facilitated by novel enkephalinase substrates.
4960702 METHODS FOR RECOVERY TISSUE PLASMINOGEN ACTIVATOR
115
OF
Craig Rice, Michael J Morser, Charles Glaser, Peter Donner assigned to Codon Methods for recovering t-PA from a liquid medium are disclosed. The methods comprise contacting a liquid medium with at least one substrate capable of effecting a separation of intact t-PA from degraded t-PA thereafter recovering the intact t-PA free from other unrelated protein. The present invention also provides compounds produced by this method, compounds comprising intact one-chain t-PA and pharmaceutical compositions containing them and methods for using such compositions.
4960704 MODIFIED ANTIBIOTIC RESISTANCE GENE Thomas D Ingolia, Kevin Kaster, R Nagaraj Rao assigned to Eli Lilly and Company A modified hygromycin B resistance-conferring gene either alone or in translational reading phase with a gene or portion of a gene is dis-
MONOCLONAL ANTIBODIES S P E C I F I C F O R 330 K D B R E A S T TUMOR ANTIGEN AND ASSAY USING SAID MONOCLONAL ANTIBODIES Michael A Harvey, Brenda D Manning, Mary L Nicholson, Karen Travis, Albert A Luderer assigned to Ciba Corning Diagnostics Corp A substantially pure antigen found on normal and benign breast epithelial cell membranes and in breast cancer cells, fused cell hybrids which produce antibodies specific for such antigen, the monoclonal antibodies produced by such fused cell hybrids, a method for detecting the presence of breast cancer in a patient which is based on measuring the concentrations of one or more determinants of such antigen in a patient sample, and a method for either identifying those breast cancer patients whose tumors would respond to estrogen manipulation or determining prognosis based on the degree of differentiation, which method is based on measuring the concentration of an estrogen-modulated determinant of such antigen.
4960756 LECTIN LIKE PROTEIN SUBSTANCE, METHOD OF OBTAINING SAME AND ANTITUMOR AGENT COMPRISING SAME Shunji Natori, Tone, Japan assigned to Sanwa Kagaku Kenkyusho Co Ltd A lectin like protein substance, method of obtaining same and a pharmaceutical agent containing the substance, as an effective ingredient. The substance is obtained through steps of cultivating a celt line stablished from Sarcophaga peregrina embryo to produce the substance in a culture medium, as product of the cell line, separating the refining the same. The substance shows an anti-tumor activity and thus is useful as an effective ingredient for medicines to cure cancers.
closed. The invention further comprises recombinant DNA cloning vectors and transformants of the aforementioned DNA.
4960716
4960700 COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND ASSAY OF A MAMMALIAN ENKEPHALINASE Bernard Malfroy-Camine, Peter R Schofield assigned to Genentech Inc DNA isolates coding for enkephalinase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of enkephalinase for use in therapeutic or diagnostic compositions. Enkephalinase assays are facilitated by novel enkephalinase substrates.
4960702 METHODS FOR RECOVERY TISSUE PLASMINOGEN ACTIVATOR
115
OF
Craig Rice, Michael J Morser, Charles Glaser, Peter Donner assigned to Codon Methods for recovering t-PA from a liquid medium are disclosed. The methods comprise contacting a liquid medium with at least one substrate capable of effecting a separation of intact t-PA from degraded t-PA thereafter recovering the intact t-PA free from other unrelated protein. The present invention also provides compounds produced by this method, compounds comprising intact one-chain t-PA and pharmaceutical compositions containing them and methods for using such compositions.
4960704 MODIFIED ANTIBIOTIC RESISTANCE GENE Thomas D Ingolia, Kevin Kaster, R Nagaraj Rao assigned to Eli Lilly and Company A modified hygromycin B resistance-conferring gene either alone or in translational reading phase with a gene or portion of a gene is dis-
MONOCLONAL ANTIBODIES S P E C I F I C F O R 330 K D B R E A S T TUMOR ANTIGEN AND ASSAY USING SAID MONOCLONAL ANTIBODIES Michael A Harvey, Brenda D Manning, Mary L Nicholson, Karen Travis, Albert A Luderer assigned to Ciba Corning Diagnostics Corp A substantially pure antigen found on normal and benign breast epithelial cell membranes and in breast cancer cells, fused cell hybrids which produce antibodies specific for such antigen, the monoclonal antibodies produced by such fused cell hybrids, a method for detecting the presence of breast cancer in a patient which is based on measuring the concentrations of one or more determinants of such antigen in a patient sample, and a method for either identifying those breast cancer patients whose tumors would respond to estrogen manipulation or determining prognosis based on the degree of differentiation, which method is based on measuring the concentration of an estrogen-modulated determinant of such antigen.
4960756 LECTIN LIKE PROTEIN SUBSTANCE, METHOD OF OBTAINING SAME AND ANTITUMOR AGENT COMPRISING SAME Shunji Natori, Tone, Japan assigned to Sanwa Kagaku Kenkyusho Co Ltd A lectin like protein substance, method of obtaining same and a pharmaceutical agent containing the substance, as an effective ingredient. The substance is obtained through steps of cultivating a celt line stablished from Sarcophaga peregrina embryo to produce the substance in a culture medium, as product of the cell line, separating the refining the same. The substance shows an anti-tumor activity and thus is useful as an effective ingredient for medicines to cure cancers.