4968614 Human pancreatic elastase I

PATENT ABSTRACTS Amplification of the HER-2/neu oncogene is related to the status of neoplastic diseases, particularly breast and ovarian adenocarcinomas. The presence of multiple gene copies in tumor cells indicates that the disease is more likely to spread beyond the primary tumor site, and that the disease therefore may require more aggressive treatment than might otherwise be indicated by other diagnostic factors. In particular, the degree of gene amplification appears to provide greater prognostic utility than either the estrogen receptor or the progesterone receptor, and provides utility equal to that of the determination of lymph node status. The information provided by the gene amplification test, however, is not duplicative with the determination of lymph node status and the two tests together provide greatly improved prognostic utility.

4968609 CORYNEFORM BACTERIA CARRYING RECOMBINANT DNA AND A PROCESS FOR PRODUCING AROMATIC AMINO ACIDS USING SAID BACTERIA Hisao Ito, Katsuaki Sato, Kazuhiko Matsui, Konosuke Sano, Shiger Nakamori, Takashi Tanaka, Hitoshi Enei, Kawasaki, Japan assigned to Ajinomoto Co Inc The present invention relates to a process for producing an aromatic amino acid which comprises culturing a Coryneform bacterium carrying a recombinant DNA constructed by connecting (1) a gene capable of being expressed in a Coryneform bacterial cell and coding for 3deoxy-D-arabino-heptulonic acid-7-phosphate synthetase with (2) a plasmid vector capable of propagating in a Coryneform bacterial cell.

4968612 CONTINUOUS FERMENTATION PROCESS FOR AROMATIC HYDROCARBON BIOCONVERSION Jih-Han Hsieh assigned to Celgene Corporation This invention provides a continuous bioconversion process in which a non-growth toluene substrate is bio-oxidized by a specific microbe mutant strain to accumulated extracellular muconic acid at a bioreactor production rate of

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at least about 5 grams ofmuconic acid per liter of fermentation medium per hour. Essential features of the invention process include a continuous feed of whole cell-containing fermentation broth from an auxiliary cell growth and enzyme induction fermentation zone into the main fermentation zone, and a purge stream of whole cell-containing fermentation broth from the main fermentation zone.

4968613 LUCIFERASE GENE AND NOVEL RECOMBINANT DNA AS WELL AS A METHOD OF PRODUCING LUCIFERASE Tsutomu Masuda, Hiroki Tatsumi, Eiichi Nakano assigned to Kikkoman Corporation A luciferase gene isolated from Luciola cruciata (Japanese firefly) coding for an amino acid sequence shown in FIG. 4 and a novel recombinant DNA characterized by incorporating a gene coding for luciferase into a vector D N A are disclosed. There is also disclosed a method of producing luciferase which comprises culturing in a medium a microorganism containing a recombinant D N A having inserted a gene coding for luciferase in a vector DNA and belonging to the genus Escherichia capable of producing luciferase and collecting luciferase from the culture.

4968614 HUMAN

PANCREATIC

ELASTASE

I Yo Takiguchi, Tokio Tani, Hidehiko Furukawa, Toshinori Ohmine, Ichiro Kawashima, Hiromachi, Japan assigned to Sankyo Company Limited Human pancreatic elastase I can be obtained by genetic engineering.

4968615 DEOXYRIBONUCLEIC ACID SEGMENT FROM A VIRUS Ulrich H Koszinowski, Gunther M Keil, Karoline Dorsch-Hasler, Walter Schaffner, Tfederal Republic Of Germana assigned to CIBA-GEIGY Corporation