4973576 Bisphophonic acid derivatives and pharmaceutical compositions containing the same

New Patents A pyridylketoxime ether compound of the formula: See Patent for Chemical Structure (I) wherein Ar is a phenyl, naphthyl, or heterocyclic group unsubstituted or substituted by a C1-C8 alkyl group, a C1-C8 alkylamino group, a C1-C8 alkoxy group, a C1-C8 alkoxycarbonyl group, a trifluoromethyl group, a nitro group or a halogen atom, X is a -(CH2)m- group wherein m is an integer of from 1 to 5, a -(CH2)m-Y- group wherein Y is an oxygen or sulfur atom and m is as defined above, or a -CH2-(CH double bondCH)n- group wherein n is an integer of 1 or 2, and R is a phenyl, naphthyl, C3-C8 cycloalkyl or heterocyclic group unsubstituted or substituted by a CI-C8 alkyl group, a C1-C8 alkylamino group, a C1-C8 alkoxy group, a C1C8 akloxycarbonyl group, a trifluoromethyl group, a nitro group or a halogen atom, or a salt thereof.

4973504 PHARMACEUTICAL ELASTOMERIC COATING Val Romberg, Patty Kiang, Wayne Curry assigned to The West C o m p a n y Incorporated An elastomeric member for use with a container and in contact with pharmaceutically pure contents therein. The elastomeric member has an elastomeric base and a continuous polyparaxylylene coating on the base. The coating ranges from about 0.5 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.0 and is capable of substantially preventing metal extraction from said elastomers.

4973576

4973470 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS Nancy L Mills, Michael R Harris, Russell U Nesbitt assigned to Warner-Lambert C o m p a n y A sustained release oral pharmaceutical composition consists essentially of a recompressed mixture of a water-sensitive pharmaceutical agent, a high molecular weight hydrophilic cellulose polymer, and a lubricant. The mixture is compressed into a unitary mass, comminuted, and recompressed into tablets without the use of solvents.

BISPHOPHONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Shuichi Sakamoto, M a k o t o Takeuchi, Yasuo Isomura, Kunihiro Niigata, Tetsushi Abe, Kousei Kawamuki, Masafumi Kudou, Tokyo, Japan assigned to Yamanouchi Pharmaceutical Co Ltd Novel bisphosphonic acid derivatives, and a bone resorption-inhibitor and an anti-arthritis containing a bisphosphonic acid derivative represented by the formula (I): See Patent for Chemical Structure (I) wherein R2 represents a hydrogen atom, an alkyl group, etc., R2 represents a hydrogen atom or a lower alkanoyl group, R3, R4, R5 and R6

4973580 4973480 TAMPER EVIDENT PHARMACEUTICAL CAPSULE Marc S Hermelin, Mitchell I Kirschner, George N Paradissis assigned to K V Pharmaceutical Co A tamper evident pharmaceutical capsule which contains an active agent. The capsule is coated on its external surfaces to provide an indication of tampering.

DEPOLYMERIZED DERMATAN SULFATES ENDOWED WITH AN ANTITHROMBOTIC, FIBRINOLYTIC, ANTIINFLAMMATORY ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH Giuseppe Mascellani, Pietro Bianchini, Corlo, Italy assigned to Opocrin S p A Laboratorio Farmacobiologico