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4975186 Container for fine separation of blood and blood components
ii
New Patents
and proteins-or disinfecting cornea1 and scleral tissues, to make them safer for human transfusion or transplantation, while respectively maintaining their biologic or optical function. A sterilizing solution is prepared from, e.g., a commercially available disinfectant (such as LD trademark of Alcide Corporation) containing primarily lactic acid and sodium chlorite. Normal saline solution is used as diluent instead of distilled water. The blood constituent or cornea or sclera is exposed to the disinfectant for a time sufficient to inactivate or reduce the infectivity of disease agents. The normal-saline environment prevents or deters hemolysis of the red blood cells or damage to the comeal or scleral epithelium or endothelium, disruption of the platelets, or denaturation of the proteins. The blood cells or platelets (or both), or the cornea or sclera (or both) are then washed with normal saline solution until the disinfectant concentration is insignificant. Plasma proteins are precipitated out as with ammonium sulfate, resuspended and dialyzed to remove residual disinfectant and coagulant, and reconstituted. The blood constitutents or eye parts are then safe for human transfusion or transplantation.
4975186 CONTAINER FOR FINE SEPARATION OF BLOOD AND BLOOD COMPONENTS Shohachi Wada, Bruc Kuhlemann Miles Laboratories Inc
assigned to
Blood and blood component container having in continuous communication therewith a receptacle adapted to receive and define a given component or sub-component when contents in the container are separated. In preferred embodiments, the container is a flexible bag having a tapered portion adjacent the receptacle to assist migration of a given component or subcomponent into the receptacle during centrifugation and at least a portion of the container is supported by a cup-like device, the inner surface of which conforms to the outer surface of the bag and communicating receptacle.
4976682
4974603 NEEDLE EJECTOR APPARATUS FOR A BLOOD SAMPLE VACUUM TUBE CONTAINER Jerome Jacobs A needle ejector apparatus to be used for removing a needle from a blood sample vacuum tube container, the apparatus being structurally adapted to receive a vacuum tube container and attached needle therein whereupon the downward depression of a push rod on the apparatus causes an engaging means to grasp a rubber cap on the needle located within the interior of the vacuum tube container. Further depression of the push rod causes rotation of a head structure and attached engaging means thereby enabling separation and ejection of the needle from the vacuum tube container after use without the necessity of the needle being touched by medical personnel. Danger of contamination by inadvertent puncture when removing the needle from the vacuum tube container is thereby eliminated.
METHODS AND APPARATUS FOR AUTOLOGOUS BLOOD RECOVERY Perry Lane, Udipi R Shettigar Improved methods and apparatus for the collection, purification and reinfusion of blood from a wound site. The present invention provides a source of anticoagulated washing fluid in proportion to the bleeding rate which can be directed to the suction tip in such a way that the wound or surgical site is washed. The present invention minimizes blood damage and maximizes blood recovery by (i) automatically regulating the suction in proportion to the bleeding rate, (ii) minimizing the air suction or blood frothing, (iii) washing the wound site with the anticoagulated washing fluid, and (iv) reducing the number of blood pumps, preferably to one. The present invention also provides a system to operate automatically by including automatic venting of entrapped air, continuous determination of irrigation fluid added into the wound site and its removal, continuous monitoring of hematocrit, continuous neutralization of anticoagulant, and reinfusion of purified blood to patient on realtime basis irrespective of bleeding rate.
New Patents
and proteins-or disinfecting cornea1 and scleral tissues, to make them safer for human transfusion or transplantation, while respectively maintaining their biologic or optical function. A sterilizing solution is prepared from, e.g., a commercially available disinfectant (such as LD trademark of Alcide Corporation) containing primarily lactic acid and sodium chlorite. Normal saline solution is used as diluent instead of distilled water. The blood constituent or cornea or sclera is exposed to the disinfectant for a time sufficient to inactivate or reduce the infectivity of disease agents. The normal-saline environment prevents or deters hemolysis of the red blood cells or damage to the comeal or scleral epithelium or endothelium, disruption of the platelets, or denaturation of the proteins. The blood cells or platelets (or both), or the cornea or sclera (or both) are then washed with normal saline solution until the disinfectant concentration is insignificant. Plasma proteins are precipitated out as with ammonium sulfate, resuspended and dialyzed to remove residual disinfectant and coagulant, and reconstituted. The blood constitutents or eye parts are then safe for human transfusion or transplantation.
4975186 CONTAINER FOR FINE SEPARATION OF BLOOD AND BLOOD COMPONENTS Shohachi Wada, Bruc Kuhlemann Miles Laboratories Inc
assigned to
Blood and blood component container having in continuous communication therewith a receptacle adapted to receive and define a given component or sub-component when contents in the container are separated. In preferred embodiments, the container is a flexible bag having a tapered portion adjacent the receptacle to assist migration of a given component or subcomponent into the receptacle during centrifugation and at least a portion of the container is supported by a cup-like device, the inner surface of which conforms to the outer surface of the bag and communicating receptacle.
4976682
4974603 NEEDLE EJECTOR APPARATUS FOR A BLOOD SAMPLE VACUUM TUBE CONTAINER Jerome Jacobs A needle ejector apparatus to be used for removing a needle from a blood sample vacuum tube container, the apparatus being structurally adapted to receive a vacuum tube container and attached needle therein whereupon the downward depression of a push rod on the apparatus causes an engaging means to grasp a rubber cap on the needle located within the interior of the vacuum tube container. Further depression of the push rod causes rotation of a head structure and attached engaging means thereby enabling separation and ejection of the needle from the vacuum tube container after use without the necessity of the needle being touched by medical personnel. Danger of contamination by inadvertent puncture when removing the needle from the vacuum tube container is thereby eliminated.
METHODS AND APPARATUS FOR AUTOLOGOUS BLOOD RECOVERY Perry Lane, Udipi R Shettigar Improved methods and apparatus for the collection, purification and reinfusion of blood from a wound site. The present invention provides a source of anticoagulated washing fluid in proportion to the bleeding rate which can be directed to the suction tip in such a way that the wound or surgical site is washed. The present invention minimizes blood damage and maximizes blood recovery by (i) automatically regulating the suction in proportion to the bleeding rate, (ii) minimizing the air suction or blood frothing, (iii) washing the wound site with the anticoagulated washing fluid, and (iv) reducing the number of blood pumps, preferably to one. The present invention also provides a system to operate automatically by including automatic venting of entrapped air, continuous determination of irrigation fluid added into the wound site and its removal, continuous monitoring of hematocrit, continuous neutralization of anticoagulant, and reinfusion of purified blood to patient on realtime basis irrespective of bleeding rate.