4983614 Benzhydryloxyethyl piperidine derivatives, process for their preparation and pharmaceutical compositions, in which they are present

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New Patents

4983614 BENZHYDRYLOXYETHYL PIPERIDINE DERIVATIVES, P R O C E S S FOR THEIR PREPARATION AND PHARMACEUTICAL C O M P O S I T I O N S , IN WHICH THEY ARE P R E S E N T Andre Merour Jean-Yves Buzas, Roland O1livier, Bievres, France assigned to Les Laboratoires M e r a m The invention relates to benzhydryloxyethylpiperidine derivatives corresponding to one of the formulae below: See Patent for Chemical Structure (I) R 1 R 2 C R 3 R 4 H O C H 2 C H 2 N C H C O O R (II) in which: R I , R2, R3 and R4, which are identical or different, represent a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aryloxy group or the trifluoromethyl group, R represents hydrogen, a cation, an alkyl group, an aryl group or an arylalkyl group, and n is equal to 0 or 1, and their pharmaceutically acceptable salts, useful in the treatment of spasmodic states and allergies.

for Chemical Structure R1 and R2 are each hydrogen or C1-6 alkyl, R3, R4, R5 and R6 are each hydrogen, hydroxy, halogen, nitro, cyano, carboxy, C1-4 alkyl, C1-4 alkoxy, C l - 4 alkylthio, halo-substituted C1-4 alkyl, halosubstituted C1-4 alkoxy, halo-substituted C1-4 alkylthio, C2-5 alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, R ' R " N - where R' and R " are each hydrogen or C1-4 alkyl or R ' " C O N H - where R ' " is C1-4 alkyl, or a group of the formula -CR7R8R9 in which R7, R8 and R9 are each C1-6 alkyl, halosubstituted C1-6 alkyl or optionally substituted phenyl, or R7 and R8, together with the carbon atom to which they are attached, form a cycloalkyl group containing 3 to 7 carbon atoms, or R7, R8 and R9 together with the carbon atom to which they are attached, form a bicycloalkyl group containing 4 to 9 carbon atoms, and Y is a 5- or 6-membered heterocyclic ring excluding pyrazole; and salts thereof.

4983632

PHARMACEUTICAL COMPOUNDS

USE OF G A M M A H Y D R O X Y B U T Y R I C ACID SALTS FOR P R E P A R I N G PHARMACEUTICAL C O M P O S I T I O N S FOR U S E IN THE T R E A T M E N T OF A L C O H O L I S M , AND THE C O M P O S I T I O N S OBTAINED

Peter T Gallagher, Terence Hicks, Yateley, United Kingdom assigned to Lilly Industries Limited

Gian Luigi Gessa, Fabio Fadda, di Campochiaro Chiara Mormile, Cagliari, Italy assigned to Laboratorio Farmaceutico C T S r 1

C o m p o u n d s of the following formula have pharmaceutical properties: See Patent for Chemical Structure in which X is R ' ( H O ) C double bondC(CN)-, R I ( C O ) - C H ( C N ) - or See Patent

The use of gamma-hydroxybutyric acid salts for preparing pharmaceutical compositions useful for the release form ethyl alcohol consumption and the compostions obtained.

4983619

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