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5013445 Method for separating immunoglobulin G. subclasses
ii
New Patents
C., each beadlet having an average diameter of about 2 to 3 millimeters and containing at least 1 viable encysted protozoan, such as a sporulated oocyst of a species of coccidium infective to poultry, each beadlet having a protective coating of animal feed, cement and/or gypsum, the protective coating having an average thickness of about 0.2 to 2 mm.
5006459 THERAPEUTIC AND DIAGNOSTIC METHODS USING SOLUBLE T CELL SURFACE MOLECULES Patrick C Kung, Stephen lp, Michae Brown, Linda A McKeen assigned to T Cell Sciences lnc The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis and therapy of diseases and disorders. The measurement of such molecules can be valuable in monitoring the effect of a therapeutic treatment on a subject, detecting and/or staging a disease in a subject, and in differential diagnosis of a physiological condition in a subject. These measurements can also aid in predicting therapeutic outcome and in evaluating and monitoring the immune status of patients. In specific embodiments, measurements of serum or plasma interleukin-2 receptor levels can be made, to detect or stage leukemia or lymphoma. In other embodiments, IL2R levels, or CD8 levels, can be used to differentially diagnose renal allograft rejection, as distinguished from Cyclosporin A nephrotoxicity. In another embodiment, CD8 levels can be measured to differentially diagnose rheumatoid arthritis, as distinct from other joint diseases. In particular embodiments, measurements of the soluble T cell surface molecules can be accomplished by sandwich enzyme immunuoassays.
A method is disclosed for discriminating between cattle vaccinated against and those infected with Brucella spp. The method involves immunoassay using a purified polysaccharide containing 4, 6-dideoxy-4-acylamido Dmannopyranosyl units obtained from B. abortus or from cross-reacting organisms, and results in improved differentiation between vaccinated and infected animals. Test kits are also disclosed for performing the assay and a process is disclosed for obtaining the O-chain polysaccharides in high purity and yield.
5008116 IMMUNOSTIMULATORY MICROSPHERE Frederick Cahn The invention relates to the use of an improved carrier or adjuvant to induce a therapeutic response to a weak antigen.
5013445 METHOD FOR SEPARATING IMMUNOGLOBULIN G. SUBCLASSES Shunichi Gohzu, Misao Horie, Kuniyo lnouye, Yokohama, Japan assigned to Tosoh Corporation A method for separating immunoglobulin G subclasses, which comprises separating immunoglobulin G subclasses by liquid chromatography by using as the solid phase a porous gel having an exclusion limit molecular weight larger than the molecular weight of immunoglobulinG, as calculated as protein, and a buffer solution having an ionic strength of from 0.1 to 2.0M.
5006463
~13~2
IMMUNOASSAYS FOR DISCRIMINATING BETWEEN BRUCELLOSIS INFECTIONS AND VACCINATIONS
METHOD TO INHIBIT ADHESION OF DISEASE-CAUSING MICROORGANISMS TO TEETH
John W Cherwonogrodzky, J Robert Duncan, Klaus Nielsen, Peter F Wright, David R Bundle, Malcolm B Perry, Kanata. Canada assigned to National Research Council of Canada
Donald I Hay, Ronald J Gibbons, Edgard G Moreno assigned to Forsyth Dental Infirmary for Children A composition and method for the inhibiting of
New Patents
C., each beadlet having an average diameter of about 2 to 3 millimeters and containing at least 1 viable encysted protozoan, such as a sporulated oocyst of a species of coccidium infective to poultry, each beadlet having a protective coating of animal feed, cement and/or gypsum, the protective coating having an average thickness of about 0.2 to 2 mm.
5006459 THERAPEUTIC AND DIAGNOSTIC METHODS USING SOLUBLE T CELL SURFACE MOLECULES Patrick C Kung, Stephen lp, Michae Brown, Linda A McKeen assigned to T Cell Sciences lnc The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis and therapy of diseases and disorders. The measurement of such molecules can be valuable in monitoring the effect of a therapeutic treatment on a subject, detecting and/or staging a disease in a subject, and in differential diagnosis of a physiological condition in a subject. These measurements can also aid in predicting therapeutic outcome and in evaluating and monitoring the immune status of patients. In specific embodiments, measurements of serum or plasma interleukin-2 receptor levels can be made, to detect or stage leukemia or lymphoma. In other embodiments, IL2R levels, or CD8 levels, can be used to differentially diagnose renal allograft rejection, as distinguished from Cyclosporin A nephrotoxicity. In another embodiment, CD8 levels can be measured to differentially diagnose rheumatoid arthritis, as distinct from other joint diseases. In particular embodiments, measurements of the soluble T cell surface molecules can be accomplished by sandwich enzyme immunuoassays.
A method is disclosed for discriminating between cattle vaccinated against and those infected with Brucella spp. The method involves immunoassay using a purified polysaccharide containing 4, 6-dideoxy-4-acylamido Dmannopyranosyl units obtained from B. abortus or from cross-reacting organisms, and results in improved differentiation between vaccinated and infected animals. Test kits are also disclosed for performing the assay and a process is disclosed for obtaining the O-chain polysaccharides in high purity and yield.
5008116 IMMUNOSTIMULATORY MICROSPHERE Frederick Cahn The invention relates to the use of an improved carrier or adjuvant to induce a therapeutic response to a weak antigen.
5013445 METHOD FOR SEPARATING IMMUNOGLOBULIN G. SUBCLASSES Shunichi Gohzu, Misao Horie, Kuniyo lnouye, Yokohama, Japan assigned to Tosoh Corporation A method for separating immunoglobulin G subclasses, which comprises separating immunoglobulin G subclasses by liquid chromatography by using as the solid phase a porous gel having an exclusion limit molecular weight larger than the molecular weight of immunoglobulinG, as calculated as protein, and a buffer solution having an ionic strength of from 0.1 to 2.0M.
5006463
~13~2
IMMUNOASSAYS FOR DISCRIMINATING BETWEEN BRUCELLOSIS INFECTIONS AND VACCINATIONS
METHOD TO INHIBIT ADHESION OF DISEASE-CAUSING MICROORGANISMS TO TEETH
John W Cherwonogrodzky, J Robert Duncan, Klaus Nielsen, Peter F Wright, David R Bundle, Malcolm B Perry, Kanata. Canada assigned to National Research Council of Canada
Donald I Hay, Ronald J Gibbons, Edgard G Moreno assigned to Forsyth Dental Infirmary for Children A composition and method for the inhibiting of