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5017487 Vaccinia DNA
PATENT ABSTRACTS
458
A brevibacterium containing a recombinant DNA molecule constructed by operatively connecting a gene coding for shikimate kinase isolated from Brevibacterium lactofermentum to a plasmid vector capable of replicating in the Brevibacterium is disclosed along with methods of preparing this bacterium and of using it in the production of aromatic amino acids.
5017482 PROCESS FOR PRODUCING L-ARGININE
5017487 VACCINIA DNA Hendrik G Stunnenberg, Riccardo Wittek, Bammental, Federal Republic Of Germany assigned to Hoffmann-La Roche lnc New transcriptional regulatory sequences useful in the expression of pro- or eukaryotic proteins in eukaryotic organisms are provided comprising the 5" flanking region of the vaccinia virus late II kDa gene. Also described are recombinant vectors and recombinant infectious poxviruses containing such transcriptional regulatory sequences operatively linked to foreign genes, and live vaccines based upon these recombinant infectious poxviruses.
Ryoichi Katsumata, Haruhiko Yokoi, Machida, Japan assigned to Kyowa Hakko Kogyo Co Ltd L-arginine is produced by constructing a recombinant DNA composed of a vector DNA and a DNA fragment derived from chromosomal D N A of a microorganism belonging to the genus Corynebacterium or Brevibacterium and bearing genetic information relating to the synthesis of L-arginine-biosynthetic enzyme, introducing the recombinant DNA in a microorganism belonging to the genus Corynebacterium or Brevibacterium, culturing the microorganism in a medium, and recovering L-arginine accumulated in the culture broth.
5017486 CLONING OF DNA ENCODING ANTIBACTERIAL POLYPEPTIDE PRECURSOR Kiich Sawai, Shunji Natori, Haruo Takahashi. Kenichi Tanaka, Takahiko Mitani. Masayasu Kurono, Aichi, Japan assigned to Sanwa Kagaku Kenkyusho Co Ltd A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand D N A consisting of the singlestrand DNA and its complementary singlestrand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, and a plasmid, in which the doublestrand DNA or its fragment is inserted are disclosed.
5017488 HIGHLY EFFICIENT DUAL T7/T3 PROMOTER VECTOR PJKFI6 AND DUAL SP6/T3 PROMOTER VECTOR PJFKI5 William T McAIlister, John F Klement assigned to University of Medicine and Dentistry of New Jersey A dual promoter cassette which has at one end a promoter for T3 RNA polymerase which contains a downstream sequence identical to a naturally occurring T3 promoter sequence and on the other end, a promoter for a phage DNA polymerase other than the T3 RNA polymerase. The recombinant DNA plasmid which includes the promoter. The plasmid is capable of highly efficient transcription of RNA with low concentrations of ribonucleoside triphosphates.
5017489 CYTOTOXIC T LYMPHOCTE SERINE ESTERASE AND METHOD FOR STIMULATION AND INHIBITION Mark S Pasternack, Herman S Eisen assigned to Massachusetts Institute of Technology Antibodies, nucleic acid .sequences. and methods for inhibition of lysis for a novel serine esterase produced by both murinc and human cytotoxic
458
A brevibacterium containing a recombinant DNA molecule constructed by operatively connecting a gene coding for shikimate kinase isolated from Brevibacterium lactofermentum to a plasmid vector capable of replicating in the Brevibacterium is disclosed along with methods of preparing this bacterium and of using it in the production of aromatic amino acids.
5017482 PROCESS FOR PRODUCING L-ARGININE
5017487 VACCINIA DNA Hendrik G Stunnenberg, Riccardo Wittek, Bammental, Federal Republic Of Germany assigned to Hoffmann-La Roche lnc New transcriptional regulatory sequences useful in the expression of pro- or eukaryotic proteins in eukaryotic organisms are provided comprising the 5" flanking region of the vaccinia virus late II kDa gene. Also described are recombinant vectors and recombinant infectious poxviruses containing such transcriptional regulatory sequences operatively linked to foreign genes, and live vaccines based upon these recombinant infectious poxviruses.
Ryoichi Katsumata, Haruhiko Yokoi, Machida, Japan assigned to Kyowa Hakko Kogyo Co Ltd L-arginine is produced by constructing a recombinant DNA composed of a vector DNA and a DNA fragment derived from chromosomal D N A of a microorganism belonging to the genus Corynebacterium or Brevibacterium and bearing genetic information relating to the synthesis of L-arginine-biosynthetic enzyme, introducing the recombinant DNA in a microorganism belonging to the genus Corynebacterium or Brevibacterium, culturing the microorganism in a medium, and recovering L-arginine accumulated in the culture broth.
5017486 CLONING OF DNA ENCODING ANTIBACTERIAL POLYPEPTIDE PRECURSOR Kiich Sawai, Shunji Natori, Haruo Takahashi. Kenichi Tanaka, Takahiko Mitani. Masayasu Kurono, Aichi, Japan assigned to Sanwa Kagaku Kenkyusho Co Ltd A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand D N A consisting of the singlestrand DNA and its complementary singlestrand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, and a plasmid, in which the doublestrand DNA or its fragment is inserted are disclosed.
5017488 HIGHLY EFFICIENT DUAL T7/T3 PROMOTER VECTOR PJKFI6 AND DUAL SP6/T3 PROMOTER VECTOR PJFKI5 William T McAIlister, John F Klement assigned to University of Medicine and Dentistry of New Jersey A dual promoter cassette which has at one end a promoter for T3 RNA polymerase which contains a downstream sequence identical to a naturally occurring T3 promoter sequence and on the other end, a promoter for a phage DNA polymerase other than the T3 RNA polymerase. The recombinant DNA plasmid which includes the promoter. The plasmid is capable of highly efficient transcription of RNA with low concentrations of ribonucleoside triphosphates.
5017489 CYTOTOXIC T LYMPHOCTE SERINE ESTERASE AND METHOD FOR STIMULATION AND INHIBITION Mark S Pasternack, Herman S Eisen assigned to Massachusetts Institute of Technology Antibodies, nucleic acid .sequences. and methods for inhibition of lysis for a novel serine esterase produced by both murinc and human cytotoxic