5034223 Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof

PATENT ABSTRACTS Active recombinant human IL-4 is purified from a crude cell culture medium of a CHO-cell lines mutant by subjecting said crude solution to two sequentialcation exchange chromatographies at pH 7.2 and 0.12M sodium chloride, selective chromatography on a cobalt-chelating agarose column at pH 7.2 in a buffer containing a high concentration of sodium chloride, i.e., about 0.SM sodium chloride, further treated by concentration (diafiltration) up to 20 mg/mL and size exclusion gel chromatography using a citrate buffer at pH 4.5.

677

to said animals an effective amount of a new antibacterial produced in a microbiological fermentation under controlled conditions using a new subspecies of Micromonospora citera and mutants thereof. The antibacterial designated LL-EI9085 alpha is a highly effective anticoccidial agent especially useful for the prophylactic, pharmaceutical, and therapeutic treatment of poultry and other animals raised for meat production.

5034316 5034223 METHODS FOR IMPROVED TARGETING OF ANTIBODY, ANTIBODY FRAGMENTS, HORMONES AND OTHER TARGETING AGENTS, AND CONJUGATES THEREOF Paul G Abrams. Robert W Schroff, Alton C Morgan assigned to NeoRx Corporation Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, specific for a population of cells of a mammal comprises steps of administering to said mammal an adequate dosage of blocking antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, and administering to said mammal an effective dosage of said antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, specific for said population of cells. In the preferred embodiment, the specific antibodies are monoclonal antibodies directed toward tumor-associated antigen in man.

5034224 METHOD AND COMPOSITION FOR TREATING PROTOZOAL INFECTIONS Sidne Kantor, Robert Kennctt assigned to American Cyanamid Company This invention relates to a method and composition for the control of protozoal infections in warm-blooded animals by orally administering

IN VITRO HUMAN MONOCLONAL IGG RHEUMATOID FACTOR AUTOANTIBODY Richard Weisbart, Romaine E Saxton assigned to The Regents of the University of California Human monoclonal IgG RF is provided in stable supply from immortalized cells. The IgG RF can be used for diagnosis and study of rheumatoid arthritis. In addition, anti-idiotype antibodies can be provided for use in diagnosis and therapy. The cell line hRF-I was deposited at the A.T.C.C. on January 16, 1991 and given accession No. ATCC 10645.

5034515 STAPHYLOCOCCAL FIBRONECTIN RECEPTOR, MONOCLONAL ANTIBODIES THERETO AND METHODS OF USE Richard A Proctor assigned to Wisconsin Alumni Research Foundation A purified fibronectin receptor polysaccharide derived from Staphylococcus aureus is useful as an antigen for diagnostic tests and the preparation of monoclonal antibodies. The fibronectin receptor polysaccharide is prepared by gently removing expresed material, including the polysaccharide, from the cell surfaces of the S. aureus without killing the cells followed by purification. Monoclonal antibodies directed against the polysaccharide can be used in methods of preventing or treating S. aureus infections by administering the monoclonal antibodies to animals.