- Email: [email protected]
5051445 3-Amino-propyloxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
xxvm
New Patents
5051406
5051433
PHARMACEUTICAL COMPOSITION USING ALBUMIN AS A CARRIER A N D P R O C E S S F O R P R O D U C I N G THE S A M E
P H A R M A C E U T I C A L L Y ACTIVE BASIC N I T R O - P H E N Y L DIHYDROPYRIDINE AMIDES
Toshlo Satoh, Tokushlma, Japan assigned to Nippon Hypox Laboratones Incorporated The pharmaceutical composmon of the present mvenUon ~s a pharmaceuUcal composmon of high drug content containing 1-200 parts by weight of a drug hawng a protem binding property and 100 parts by weight of alburmn This pharmaceutical composmon ts produced by sUrnng the drug and albumin of the above proportions at a Ingh speed m an aqueous solvent and then remowng the solvent by &stfllauon, and has effects of allewatmg the side effect of the drug used thereto and also of lmprowng the absorption, hght stabdlty, etc of the drug
Jurgen Stoltefuss, Eckhard Schwenner, Ramer Gross, Slegbert Heblsch, Matthms Schramm, Martin Bechem, Claudm Hlrth, Johannes-Peter Stasch, Haan, Federal Repubhc Of Germany assigned to Bayer AkUengesellschaft Hypertension and car&ac insufficiency can be controlled by 4-mtrophenyl-dlhydropyndme amides of the formula See Patent for Chemwal Structure m winch X can be ethylene or the hke, Y is pyndyl or -NR9R10, and R9 and R10 each independently is hydrogen or an organic group, or together form a nng, and physiologically tolerated salts thereof Compounds m winch R5 and R6 are not aryl or aralkyl are new
5051435 PHARMACEUTICAL PREPARATIONS 5051412 P H A R M A C E U T I C A L L Y ACTIVE 3-(1,2,5,6 TETRAHYDROPYRIDYL) PYRROLOPYRIDINES John E Macor assigned to Pfizer Inc PCT No PCT/US89/00231 Sec 371 Date Sep. 17, 1990 Sec 102(e) Date Sep. 17, 1990 PCT Flied Jan 23, 1989 Compounds of the formula See Patent for Chermcal Structure I whereto one of A, B, D and E is N and the remmmng three atoms are C; R1 and R2 are independently selected from hydrogen and C1 to C6 alkyl; and R3, R4, R5 and R6 are independently selected from hydrogen, halogen, hydroxy, C1-C6 alkyl, C1C8 alkoxy, phenyl-C1-C6 alkoxy, phenoxy NR7R8 whereto R7 and R8 are independently selected from hydrogen, C1-C8 alkyl, C1-C6 alkanoyl and COOR9 whereto R9 is hydrogen or C1-C6 alkyl, cyano, COOR10 whereto R10 is hydrogen or C1-C6 alkyl, and C O N R l l R 1 2 where R10 and R11 are independently selected from hydrogen and C1-C6 alkyl, and the pharmaceutically acceptable salts thereof The compounds are useful psychotherapeutacs and may be used m treating obesity, depression and &sorders whereto aggression is a symptom.
Hennch H Para&es, Kuhloweg, Federal Repubhc Of Germany assigned to Me&ce Chem -Pharm Fabnk Putter GmbH & Co KG The synthesis of quaternary five membered N-nalkyl-hetero-cycles, especially of 4-hydroxy-N (l)-n-alkyl-lmldazohum, 2,5-substituted N(3)-nalkyl-thlazohum and substituted N(2) pyrazohum salts are described The Nsurfactants obtained have a very small cnUcal mlcelle concentration (CMC) of 10-5-10-7 Mol/Llter, and are capable of forming mlcelles of different sizes and forms depending on the nature of the anions The N-detergents can be used as pharmaceuucals
5051445 3-AMINO-PROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Wllham Lotus, Max-Pete Seder, Andre Stoll, Vlctona, Austraha assigned to Lores Wdliam
New Patents
5051406
5051433
PHARMACEUTICAL COMPOSITION USING ALBUMIN AS A CARRIER A N D P R O C E S S F O R P R O D U C I N G THE S A M E
P H A R M A C E U T I C A L L Y ACTIVE BASIC N I T R O - P H E N Y L DIHYDROPYRIDINE AMIDES
Toshlo Satoh, Tokushlma, Japan assigned to Nippon Hypox Laboratones Incorporated The pharmaceutical composmon of the present mvenUon ~s a pharmaceuUcal composmon of high drug content containing 1-200 parts by weight of a drug hawng a protem binding property and 100 parts by weight of alburmn This pharmaceutical composmon ts produced by sUrnng the drug and albumin of the above proportions at a Ingh speed m an aqueous solvent and then remowng the solvent by &stfllauon, and has effects of allewatmg the side effect of the drug used thereto and also of lmprowng the absorption, hght stabdlty, etc of the drug
Jurgen Stoltefuss, Eckhard Schwenner, Ramer Gross, Slegbert Heblsch, Matthms Schramm, Martin Bechem, Claudm Hlrth, Johannes-Peter Stasch, Haan, Federal Repubhc Of Germany assigned to Bayer AkUengesellschaft Hypertension and car&ac insufficiency can be controlled by 4-mtrophenyl-dlhydropyndme amides of the formula See Patent for Chemwal Structure m winch X can be ethylene or the hke, Y is pyndyl or -NR9R10, and R9 and R10 each independently is hydrogen or an organic group, or together form a nng, and physiologically tolerated salts thereof Compounds m winch R5 and R6 are not aryl or aralkyl are new
5051435 PHARMACEUTICAL PREPARATIONS 5051412 P H A R M A C E U T I C A L L Y ACTIVE 3-(1,2,5,6 TETRAHYDROPYRIDYL) PYRROLOPYRIDINES John E Macor assigned to Pfizer Inc PCT No PCT/US89/00231 Sec 371 Date Sep. 17, 1990 Sec 102(e) Date Sep. 17, 1990 PCT Flied Jan 23, 1989 Compounds of the formula See Patent for Chermcal Structure I whereto one of A, B, D and E is N and the remmmng three atoms are C; R1 and R2 are independently selected from hydrogen and C1 to C6 alkyl; and R3, R4, R5 and R6 are independently selected from hydrogen, halogen, hydroxy, C1-C6 alkyl, C1C8 alkoxy, phenyl-C1-C6 alkoxy, phenoxy NR7R8 whereto R7 and R8 are independently selected from hydrogen, C1-C8 alkyl, C1-C6 alkanoyl and COOR9 whereto R9 is hydrogen or C1-C6 alkyl, cyano, COOR10 whereto R10 is hydrogen or C1-C6 alkyl, and C O N R l l R 1 2 where R10 and R11 are independently selected from hydrogen and C1-C6 alkyl, and the pharmaceutically acceptable salts thereof The compounds are useful psychotherapeutacs and may be used m treating obesity, depression and &sorders whereto aggression is a symptom.
Hennch H Para&es, Kuhloweg, Federal Repubhc Of Germany assigned to Me&ce Chem -Pharm Fabnk Putter GmbH & Co KG The synthesis of quaternary five membered N-nalkyl-hetero-cycles, especially of 4-hydroxy-N (l)-n-alkyl-lmldazohum, 2,5-substituted N(3)-nalkyl-thlazohum and substituted N(2) pyrazohum salts are described The Nsurfactants obtained have a very small cnUcal mlcelle concentration (CMC) of 10-5-10-7 Mol/Llter, and are capable of forming mlcelles of different sizes and forms depending on the nature of the anions The N-detergents can be used as pharmaceuucals
5051445 3-AMINO-PROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Wllham Lotus, Max-Pete Seder, Andre Stoll, Vlctona, Austraha assigned to Lores Wdliam