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5098998 Cholera vaccines and peptides
New Patents 53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
5098827 NOVEL BACTERIAL MARKERS FOR PATHOGENIC GROUP B STREPTOCOCCI
ment methods include the steps of desialylating the immunoglobulin; and fragmenting the immunoglobulin produced in the desialylating step. A particular advantage of the present invention is that the fragrnention step can be carried out in the presence of cysteine without decreasing the quality of the immunoglobulin fragment product. Methods of enhancing the molecular weight homogeneity of immunoglobulin or fragmented immunoglobulin exhibiting anomalous bands when analyzed by SDS-PAGE techniques are also discussed. These methods include the steps of desialylating the immunoglobulin or fragmented immunoglobulin and purifying the desialylated product.
Michael D P Boyle, L J Brady assigned to The University of Florida The subject invention concerns a novel in vitro process for identifying and quantifying native antigens on potentially pathogenic group B streptococci bacteria present in a clinical specimen. The invention process is made possible by the discovery of novel bacterial markers denoted gamma and delta epitopes which are expressed by a variety of group B streptococcal strains.
5098998 CHOLERA VACCINES PEPTIDES
AND
John J Mekalanos, Ronald K Taylor assigned to President and Fellows of Harvard College The gene encoding the TcpA pilus has been cloned. It encodes a protein useful in live, killedcell, and synthetic vaccines. Protein production is enhanced by specific medium conditions.
5099005 METHOD OF ENHANCING IMMUNOGLOBULIN FRAGMENT PRODUCTION Everett J Nichols, Robert F Mclntyre assigned to NeoRx Corporation Methods of enhancing immunoglobulin fragment yield of immunoglobulins exhibiting anomalous bands when analyzed by SDS-PAGE techniques are provided. Such yield enhance-
5100664 HUMAN
IL-2 AS A VACCINE ADJUVANT
Michael V Doyle, Arthur D Newell, Jack H Nunberg, Thomas J White, Gary A Anderson assigned to Cetus Corporation Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days post-vaccination. In addition, compositions for enhancing the immune response of an animal to a vaccine employ IL-2 as an active ingredient, preferably human IL-2.
5100776 IMMUNOLOGICAL DETECTION PROCESS FOR HERBICIDES Woifgang Pfeiffer, Rudolf H Dittel, Wolfgang Mies, Feldafing, Federal Republic Of Germany assigned to Dr Pfeiffer Bioanalytik KG The invention concerns an immunological detection process, with which triazinesand structurally similar compounds and/or biologically equivalent compounds with similar bonding behavior are detected as belonging to one activity class, but with which on the other hand it is possible to identify the individual substances even in complicated mixtures.
5098827 NOVEL BACTERIAL MARKERS FOR PATHOGENIC GROUP B STREPTOCOCCI
ment methods include the steps of desialylating the immunoglobulin; and fragmenting the immunoglobulin produced in the desialylating step. A particular advantage of the present invention is that the fragrnention step can be carried out in the presence of cysteine without decreasing the quality of the immunoglobulin fragment product. Methods of enhancing the molecular weight homogeneity of immunoglobulin or fragmented immunoglobulin exhibiting anomalous bands when analyzed by SDS-PAGE techniques are also discussed. These methods include the steps of desialylating the immunoglobulin or fragmented immunoglobulin and purifying the desialylated product.
Michael D P Boyle, L J Brady assigned to The University of Florida The subject invention concerns a novel in vitro process for identifying and quantifying native antigens on potentially pathogenic group B streptococci bacteria present in a clinical specimen. The invention process is made possible by the discovery of novel bacterial markers denoted gamma and delta epitopes which are expressed by a variety of group B streptococcal strains.
5098998 CHOLERA VACCINES PEPTIDES
AND
John J Mekalanos, Ronald K Taylor assigned to President and Fellows of Harvard College The gene encoding the TcpA pilus has been cloned. It encodes a protein useful in live, killedcell, and synthetic vaccines. Protein production is enhanced by specific medium conditions.
5099005 METHOD OF ENHANCING IMMUNOGLOBULIN FRAGMENT PRODUCTION Everett J Nichols, Robert F Mclntyre assigned to NeoRx Corporation Methods of enhancing immunoglobulin fragment yield of immunoglobulins exhibiting anomalous bands when analyzed by SDS-PAGE techniques are provided. Such yield enhance-
5100664 HUMAN
IL-2 AS A VACCINE ADJUVANT
Michael V Doyle, Arthur D Newell, Jack H Nunberg, Thomas J White, Gary A Anderson assigned to Cetus Corporation Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days post-vaccination. In addition, compositions for enhancing the immune response of an animal to a vaccine employ IL-2 as an active ingredient, preferably human IL-2.
5100776 IMMUNOLOGICAL DETECTION PROCESS FOR HERBICIDES Woifgang Pfeiffer, Rudolf H Dittel, Wolfgang Mies, Feldafing, Federal Republic Of Germany assigned to Dr Pfeiffer Bioanalytik KG The invention concerns an immunological detection process, with which triazinesand structurally similar compounds and/or biologically equivalent compounds with similar bonding behavior are detected as belonging to one activity class, but with which on the other hand it is possible to identify the individual substances even in complicated mixtures.