5130310 Substituted benzo(b)pyrans, processes for their preparation, their use and pharmaceutical preparations based on these compounds

New Patents

5130255 PROCESS FOR PREPARING STORAGE STABLE PHARMACEUTICALS John E Battersby, Wdham S Hancock, Virgil Lawhs assigned to Genentech Inc

B

Contmner systems for stable storage of pharmaceutical compounds are &sclosed The container systems prevent the formation of adducts between pharmaceuUcal compounds and aldehydes dunng storage of these compounds m containers sealed with elastomenc stoppers that leach aldehydes Methods for deterrmmng the presence of these adducts are also disclosed

x~x

Benzo(b)pyran denvatwes of the formula I See Patent for Chemwal Structure I with E-D equal to CH-CHOH or C double bondCH; X equal to oxygen or sulfur, Y equal to oxygen, sulfur, SO, SO2 or NR9, R1 equal to CN, NO2, Hal, alkoxycarbonyl, SO1-2-alkyl or SO1-2-aryl, R2 equal to H, OH, alkoxy, alkyl, Hal, NR10R11, R3/R4 equal to alkyl, R5/R6 equal to alkyl, (CH2)I6COO-alkyl, (CH2)I-6CONR10R11, (CH2)06COOH, (CH2) l-6CO-alkyl, CO2-alkyl, alkylmercaptoalkyl, alkylsulfi(0(o)nyl, hydroxyalkyl, mercaptoalkyl, ammoalkyl, N-(d0alkylammoalkyl or (CH2)fAr with f equal to zero-3, R7/R8 equal to hydrogen, alkyl or phenyl, and m equal to zero-2 are outstanding anUhypertenslves and spasmolyt~cs PreparaUon processes and use are described

5130304

5130317

N-HETEROCYCLIC PROPYLIDENE-I,1 BISPHOSPHONIC ACIDS, THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION

PYRIMIDINE-4,6 DICARBOXYLIC ACID DIAMIDES, PROCESSES FOR THE USE THEREOF, AND PHARMACEUTICALS BASED ON THESE C O M P O U N D S

Ernst T Bmderup, Sve Lnsberg, T£522 strup, Denmark assigned to Leo Pharmaceutacal Products Ltd The present mvenUon relates to compounds of formula m which R1-R8 can be the same or different and stand for hydrogen or a strmght or branched ahphaUc C 1-C 10 hydrocarbon ra&cal. In addmon, R3 when taken together with either R1 or R5 can form a saturated ahphaUc 5-, 6-or 7-membered nng, which may be substituted with one or more C1-C4-alkyl ra&cals The present compounds are effective e g. m drugs influencing calcaum metabohsm

5130310 SUBSTITUTED BENZO(B)PYRANS, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE C O M P O U N D S Klaus Weldman, Hemnch C Englert, Bernward Scholkens, Martin Blckel, Kronberg/Taunus, Federal Repubhc Of Germany asslgned to Hoechst Aktaengesellschaft

Ekkehard Baader, Martin Blckel, Volkmar Gunzler-Pukall, Stephan Henke, Kfederal Repubhc Of Germana assigned to Hoechst Akuengesellschaft Pynmldme-4,6-&carboxyhc acid dlamldes, processes for the use thereof, and pharmaceuticals based on these compounds The mvenUon relates to pyrtmldme-4,6-&carboxyllc acid dlamldes of the formula I See Patent for Chemtcal Structure (I) in whch R1 and R2 have the meanmgs given The compounds according to the invention inhibit prohne hydroxylase and lyslne hydroxylase and can be employed as fibrosuppressants and ~mmunosuppressants

5130339 PHENYLETHANOLAMINO METHYLTETRALINS AND PHARMACEUTICAL USE Roberto Cecchl, Umberto Guzm, Lo&, Italy assigned to Sanofi New phenylethanolammo methyltetrahns of formula (I) See Patent for Chemwal Structure (I) whereto E represents hydrogen, (C1-C4)alkyl, (C1-C4)alkoxy, phenyl, nitro, halogen, or tnfluoromethyl, L represents hydrogen, (C1C4)alkyl, (C1-C4)alkyoxy, phenyl, mtro, or