- Email: [email protected]
5158940 Use of suramin to treat rheumatologic diseases
viii
New Patents
percent are shown for varying conditions. A method for facilitating the injections of virus vaccines is disclosed.
5158769 PRE-S GENE CODED PEPTIDE HEPATITIS B IMMUNOGENS, VACCINES, DIAGNOSTICS, AND SYNTHETIC LIPID VESICLE CARRIERS Alexander R Neurath, Stephen B Kent assigned to New York Blood Center Inc; California Institute of Technolo A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
5158870 DIAGNOSTIC METHODS FOR MYCOPLASMA GENITALIUM INFECTIONS Joel B Baseman, Janice Morrison-Plummer assigned to Board of Regents The University of Texas System Monoclonal antibodies binding Mycoplasma genitalium more strongly than Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma orale, Mycoplasma salivarium and Acholeplasm laidlawii are described herein. These monoclonal antibodies are utilized in immunoassays directed toward the detection of M. genitalium infections. Hybridomas producing the above-described monoclonal anti-
bodies have been created and isolated. These monoclonal antibodies are directed toward M. genitalium antigens. Certain antibodies bind protein antigens, while others bind lipid antigens. In one case a particular antibody apparently has binding affinity for both protein and lipid antigens of M. genitalium.
5158884 IMMUNODOMINANT ACETYLCHOLINE RECEPTOR PEPTIDES USEFUL FOR THELPER CELL SENSITIZATION Bianca M Conti-Tronconi, Maria P Protti assigned to Regents of the University of Minnesota The present invention provides four synthetic peptides corresponding to subunits of the alphasubunit of the nicotinic acetyl choline receptor (AChR) which have formulas (1-4): (1) gln-il eval-thr-thr-asn-val-arg leu-lys-gln-gln-trp-valasp tyr-asn-leu-lys-trp; (2) ala-ile-val-lys-phe thr-lys-val-leu-leu-gln-tyrthr-gly-his-ile-thr-trpth r-pro; (3) ser-thr-his-val-met-pro-asn trp-valarg-lys-val-phe ile-asp-thr-ile-pro-as n; and (4) ile-ile-gly-thr-leu-ala val-phe-ala-gly-arg-leu-ile glu-leu-asn-gln-gln-gl y; as well as biologically active fragments thereof, and anti-AChR Thelper cell populations having receptor sites therefor.
5158940 USE OF SURAMIN TO TREAT RHEUMATOLOGIC DISEASES Renato LaRocca, Cy A Stein, Michael Cooper, Charles Myers assigned to The United States Government as represented by the Secretary DHHS Polysulfonated compounds such as suramin are used to treat immunoregulatory disorders. Particular use in the treatment of rheumatologic diseases such as rheumatoid arthritis is shown.
5164320 METHOD FOR LYSING HARD LIPOSOMES USING POLYETHYLENEGLYCOL MONO-N-ALKYL ETHERS Herman Rutner, Abdul M Butt, Marie M Sylvestre, Josephine D Readio, Lewis Pollack assigned to Becton Dickinson and Company
New Patents
percent are shown for varying conditions. A method for facilitating the injections of virus vaccines is disclosed.
5158769 PRE-S GENE CODED PEPTIDE HEPATITIS B IMMUNOGENS, VACCINES, DIAGNOSTICS, AND SYNTHETIC LIPID VESICLE CARRIERS Alexander R Neurath, Stephen B Kent assigned to New York Blood Center Inc; California Institute of Technolo A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
5158870 DIAGNOSTIC METHODS FOR MYCOPLASMA GENITALIUM INFECTIONS Joel B Baseman, Janice Morrison-Plummer assigned to Board of Regents The University of Texas System Monoclonal antibodies binding Mycoplasma genitalium more strongly than Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma orale, Mycoplasma salivarium and Acholeplasm laidlawii are described herein. These monoclonal antibodies are utilized in immunoassays directed toward the detection of M. genitalium infections. Hybridomas producing the above-described monoclonal anti-
bodies have been created and isolated. These monoclonal antibodies are directed toward M. genitalium antigens. Certain antibodies bind protein antigens, while others bind lipid antigens. In one case a particular antibody apparently has binding affinity for both protein and lipid antigens of M. genitalium.
5158884 IMMUNODOMINANT ACETYLCHOLINE RECEPTOR PEPTIDES USEFUL FOR THELPER CELL SENSITIZATION Bianca M Conti-Tronconi, Maria P Protti assigned to Regents of the University of Minnesota The present invention provides four synthetic peptides corresponding to subunits of the alphasubunit of the nicotinic acetyl choline receptor (AChR) which have formulas (1-4): (1) gln-il eval-thr-thr-asn-val-arg leu-lys-gln-gln-trp-valasp tyr-asn-leu-lys-trp; (2) ala-ile-val-lys-phe thr-lys-val-leu-leu-gln-tyrthr-gly-his-ile-thr-trpth r-pro; (3) ser-thr-his-val-met-pro-asn trp-valarg-lys-val-phe ile-asp-thr-ile-pro-as n; and (4) ile-ile-gly-thr-leu-ala val-phe-ala-gly-arg-leu-ile glu-leu-asn-gln-gln-gl y; as well as biologically active fragments thereof, and anti-AChR Thelper cell populations having receptor sites therefor.
5158940 USE OF SURAMIN TO TREAT RHEUMATOLOGIC DISEASES Renato LaRocca, Cy A Stein, Michael Cooper, Charles Myers assigned to The United States Government as represented by the Secretary DHHS Polysulfonated compounds such as suramin are used to treat immunoregulatory disorders. Particular use in the treatment of rheumatologic diseases such as rheumatoid arthritis is shown.
5164320 METHOD FOR LYSING HARD LIPOSOMES USING POLYETHYLENEGLYCOL MONO-N-ALKYL ETHERS Herman Rutner, Abdul M Butt, Marie M Sylvestre, Josephine D Readio, Lewis Pollack assigned to Becton Dickinson and Company