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5196338 Recombinant vectors for haemophilus influenzae peptides and proteins
PATENT ABSTRACTS
237
5196338
5198215
RECOMBINANT VECTORS FOR HAEMOPHILUS INFLUENZAE PEPTIDES AND PROTEINS
COMPOSITION FOR CONTROLLING MASTITIS IN RUMINANTS, METHOD FOR ITS PREPARATION AND METHOD OF TREATMENT OF RUMINANTS
Algis Anilionis, Robert C Seid, Robert Deich, Gary W Zlotnick, Bruce Green assigned to Praxis Biologics Inc Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid D N A and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both live and inactivated are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.
Bernard J C H De Cueninck, Brugge, Belgium assigned to Noordzee Laboratorium N V The invention presents a composition for controlling mastiffs in ruminants, a method for preparing the composition and a method of treatment of ruminants. The composition contains one or more soluble exoantigens of grampositive bacteria involved in mastitis, or immunochemical homologues thereof, in a modified form which creates or enhances their ability to induce acquired mammary hypersensitivity. Said composition may be used as a vaccine or as part of a vaccine for ruminants.
5198464 METHOD AND COMPOSITIONS FOR HELMINTIC, ARTHROPOD ECTOPARASITIC AND ACARIDAL INFECTIONS WITH NOVEL AGENTS Irwin B Wood, John A Pankavich assigned to American Cyanamid Company
5196342 BACILLUS THURINGIENSIS TOXIN GENE
P-2
William Donovan assigned to PruTech R&D Partnership II This invention relates to a crystalline protein toxin useful as a biological insecticide which is known as P-2 toxin, or P-2 delta-endotoxin and which is produced by Bacillus thuringiensis. More specifically, this invention relates to the cloning and expression in various microorganisms of the gene coding for the P-2 deltaendotoxin.
The present invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249 alpha, beta, gamma, delta, epsilon, xi, eta, theta, tau, kappa, lambda, mu, nu, and omega, or mixtures thereof. The invention also relates to methods for the control of plant nematode infestations and other insecticidal activities. These novel agents are produced via a controlled conditioned microbiological fermentation using Streptomyces cyaneogriseus ssp. noncyanogenus, designated LL-F28249 and having deposit accession number N R R L 15773.
237
5196338
5198215
RECOMBINANT VECTORS FOR HAEMOPHILUS INFLUENZAE PEPTIDES AND PROTEINS
COMPOSITION FOR CONTROLLING MASTITIS IN RUMINANTS, METHOD FOR ITS PREPARATION AND METHOD OF TREATMENT OF RUMINANTS
Algis Anilionis, Robert C Seid, Robert Deich, Gary W Zlotnick, Bruce Green assigned to Praxis Biologics Inc Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid D N A and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both live and inactivated are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.
Bernard J C H De Cueninck, Brugge, Belgium assigned to Noordzee Laboratorium N V The invention presents a composition for controlling mastiffs in ruminants, a method for preparing the composition and a method of treatment of ruminants. The composition contains one or more soluble exoantigens of grampositive bacteria involved in mastitis, or immunochemical homologues thereof, in a modified form which creates or enhances their ability to induce acquired mammary hypersensitivity. Said composition may be used as a vaccine or as part of a vaccine for ruminants.
5198464 METHOD AND COMPOSITIONS FOR HELMINTIC, ARTHROPOD ECTOPARASITIC AND ACARIDAL INFECTIONS WITH NOVEL AGENTS Irwin B Wood, John A Pankavich assigned to American Cyanamid Company
5196342 BACILLUS THURINGIENSIS TOXIN GENE
P-2
William Donovan assigned to PruTech R&D Partnership II This invention relates to a crystalline protein toxin useful as a biological insecticide which is known as P-2 toxin, or P-2 delta-endotoxin and which is produced by Bacillus thuringiensis. More specifically, this invention relates to the cloning and expression in various microorganisms of the gene coding for the P-2 deltaendotoxin.
The present invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249 alpha, beta, gamma, delta, epsilon, xi, eta, theta, tau, kappa, lambda, mu, nu, and omega, or mixtures thereof. The invention also relates to methods for the control of plant nematode infestations and other insecticidal activities. These novel agents are produced via a controlled conditioned microbiological fermentation using Streptomyces cyaneogriseus ssp. noncyanogenus, designated LL-F28249 and having deposit accession number N R R L 15773.