521. Construction and Characterization of a Minimal Bovine Immunodeficiency Virus Based Lentiviral Vector

521. Construction and Characterization of a Minimal Bovine Immunodeficiency Virus Based Lentiviral Vector

"  520. Developing EIA VV ectors Suitable for Clinical EIAV Vectors Applications Carlos E. Ibanez,1 Holger Roehl,2 Jonathan B. Rohll,3 Davi...

135KB Sizes 0 Downloads 17 Views

"  520. Developing EIA VV ectors Suitable for Clinical EIAV Vectors Applications Carlos E. Ibanez,1 Holger Roehl,2 Jonathan B. Rohll,3 David A. Driver,3 Diana K. Hoganson,1 Douglas J. Jolly.1,2,3 1 Product and Process Development, BioMedica Inc., San Diego, CA, United States; 2Viral Vector Biology, BioMedica Inc., San Diego, CA, United States; 3Viral Vector Systems, BioMedica, San Diego, CA, United States. D        

  

                                      !  ′     '            

                   "       "           

 (                     1   



           ?                                                                 0

  

              .(.             >'. 

       -<) I  

I855:I&I86:8/   -<2@   #   >GI ! / 3

              

              1          :      "            

 :N,9        T& :      6         

    6 D  T8 :    % D        3       

   >3                     

 0

                                                       

    0                 G    >3     

     3                                         8   

521. Construction and Characterization of a Minimal Bovine Immunodeficiency V irus Based Lentiviral V ector Virus Vector Rene P. Molina,1 Meghan Matukonis,1 Robert Berkowitz,1 Mike Kaleko,1 Tianci Luo.1 1 Genetic Therapy Inc. A Novartis Company, Gaithersburg, Md, United States.            

         

                                              2               

 

                            

  

      -2./   

  

       



   2. @       -@@>/  =8=    >    ?      

                   2.              899                 2.       

         2. 

                         " D @   1       

   @@>                        "          

     

  2.      %  @ %@@>                     

            

 

    



       



       

                         

          

          8389B                 

                                                    

          

S172

522. Development of Second and Third Generation Bovine Immunodeficiency V irus Based Gene T ransfer Virus Transfer Systems Meghan K. Matukonis,1 Mengtao Li,1 Rene P. Molina,1 Mike Kaleko,1 Tianci Luo.1 1 Research, Genetic Therapy Inc., Gaithersburg, Maryland, United States. D    

                

      

                             '                  

           -2./   

  

 -2 G   ,998/                C. 1    -

      /      -       / 2. 

    '       -   3/              

       

         ?                 

3  @                  2.              .(." 3     2.       

       

                           

        8 3 89B                 

                               -/              3           2.       -/                    

    I   -/ 2.                   

           

523. In Vivo Sustained Gene Expression Mediated by Bovine Immunodeficiency V irus Based Lentiviral V ector Virus Vector Tianci Luo,1 Kyoichi Takahashi,2 Yoshitsugu Saishin,2 Yumiko Saishin,2 Jennifer Sung,2 Sean Hackett,2 Kim Brazzell,1 Mike Kaleko,1 Peter Campochiaro.2 1 Lentiviral Vector Program, Genetic Therapy, Inc./A Novartis Company, Gaithersburg, MD, United States; 2The Department of Ophthalmology & Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, United States. ' 2     .   -2./ 

             

  

 .(."   

 2.        

                          3

              2.    



      3    ' 2.      

        - ?!/   E 

            -& 3 89 &     %   / )             ?! 3     

    

     -@!>/    

 -    3/      

  -    3/          @!>           ?! 3                    ?           3  

   2.    



    3          2. 

                          C. 

          

524. A REV/RRE Independent Codon Optimized Bovine Immunodeficiency Virus Based Packaging System Rene P. Molina,1 Mengtao Li,1 Meghan Matukonis,1 Mike Kaleko,1 Tianci Luo.1 1 Genetic Therapy Inc. A Novartis Company, Gaithersburg, Md, United States. @     D    -@D/   

   E       

          

                   #G          

                     

           @D 0     G

  2

   .   -2./ 

     G

                 2. %!    #.      

               1   

        2.        Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy