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5214030 Calcitonin gene-related peptides for treating erectile dysfunctions
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PATENT ABSTRACTS
5214030
5214133
CALCITONIN GENE-RELATED PEPTIDES FOR TREATING ERECTILE DYSFUNCTIONS
SCL: A HEMATOPOIETIC GROWTH AND DIFFERENTIATION FACTOR
Geor Stief, D 3005 Hemmingen Westerfeld, Federal Republic Of Germany
llan R Kirsch, C Glenn Begley assigned to The United States of America as represented by the Secretary of the Department of Health and Human Services
A method of treating erectile dysfunctions in mammals and men, by administering to the mammal or man a pharmaceutical composition comprising a therapeutically effective amount of a calcitonin gene-related peptide.
5214132 POLYPEPTIDE DERIVATIVES OF HUMAN GRANULOCYTE COLONY STIMULATING FACTOR Tetsuro Kuga, Hiromas Miyaji, Moriyuki Sato, Masami Okabe, Makot Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshihar Yokoo, Kazu Yamaguchi, Hajime Yoshida, Yoshinor Komatsu, Yamaguchi, Japan assigned to Kyowa Hakko Kogyo Co Ltd Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
We have identified a new human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. Here we report the sequence of a cDNA for the normal SCL transcript, as well as for an aberrant fusion transcript produced in the leukemic cells. Although different at their 3' untranslated regions, both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif of the Lyl- 1, myc, MyoD; Ig enhancer binding, daughterless,'and achaetescute families of genes. For these cDNAs, two forms of the SCL protein (greater than 20 and 30 kD) are predicted, both of which retain this putative DNA binding domain. The pattern of expression of SCL mRNA is primarily predominant in early hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis.
5214136 ANTHRAQUINONE DERIVATIVES OLIGONUCLEOTIDES Kuei-Ying Lin, Mark Matteucci assigned to Gilead Sciences Inc Oligonucleotide sequences modified by conjugation to at least one unsubstituted or substituted anthraquinone at other than the 5' terminus have favorable properties in enhancing hybridization to target DNA or RNA without loss of specificity and show enhanced stability to nucleases.
PATENT ABSTRACTS
5214030
5214133
CALCITONIN GENE-RELATED PEPTIDES FOR TREATING ERECTILE DYSFUNCTIONS
SCL: A HEMATOPOIETIC GROWTH AND DIFFERENTIATION FACTOR
Geor Stief, D 3005 Hemmingen Westerfeld, Federal Republic Of Germany
llan R Kirsch, C Glenn Begley assigned to The United States of America as represented by the Secretary of the Department of Health and Human Services
A method of treating erectile dysfunctions in mammals and men, by administering to the mammal or man a pharmaceutical composition comprising a therapeutically effective amount of a calcitonin gene-related peptide.
5214132 POLYPEPTIDE DERIVATIVES OF HUMAN GRANULOCYTE COLONY STIMULATING FACTOR Tetsuro Kuga, Hiromas Miyaji, Moriyuki Sato, Masami Okabe, Makot Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshihar Yokoo, Kazu Yamaguchi, Hajime Yoshida, Yoshinor Komatsu, Yamaguchi, Japan assigned to Kyowa Hakko Kogyo Co Ltd Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
We have identified a new human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. Here we report the sequence of a cDNA for the normal SCL transcript, as well as for an aberrant fusion transcript produced in the leukemic cells. Although different at their 3' untranslated regions, both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif of the Lyl- 1, myc, MyoD; Ig enhancer binding, daughterless,'and achaetescute families of genes. For these cDNAs, two forms of the SCL protein (greater than 20 and 30 kD) are predicted, both of which retain this putative DNA binding domain. The pattern of expression of SCL mRNA is primarily predominant in early hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis.
5214136 ANTHRAQUINONE DERIVATIVES OLIGONUCLEOTIDES Kuei-Ying Lin, Mark Matteucci assigned to Gilead Sciences Inc Oligonucleotide sequences modified by conjugation to at least one unsubstituted or substituted anthraquinone at other than the 5' terminus have favorable properties in enhancing hybridization to target DNA or RNA without loss of specificity and show enhanced stability to nucleases.