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5242681 Lipophilic contrast agents for diagnostic image analysis
XIII
New Patents other, they respectively generate circularlypolarized high-frequency magnetic fields in the examination volume which are in-phase. In a reception mode, the signals induced in the diagonally disposed coils are superimposed inphase.
5241515 METHOD AND DEVICE FOR DETERMINING VARIATIONS IN THE POSITION OF A MOVABLE OBJECT BY MEANS OF ULTRASOUND Edwin Harms, Willem Prins, Groningen, Netherlands assigned to U S Philips Corp Variations in the position of a part of a living object within the measurement space of magnetic resonance apparatus are determined by an ultrasound device in which bursts of ultrasonic waves having a frequency FUS are transmitted towards the object in response to start signals generated to the repetition frequency FR, and ultrasonic waves reflected by the object are received and an analog echo signal is detected which is converted into a digital echo signal made up of a sequence of echo pulses having a repetition frequency FUS. The device includes a controller for generating a time-window, for determining whether a predetermined edge of an echo pulse occurs within the time-window, and for setting the time for generating the next timewindow at l/FR-1/2FUS after an echo pulse has occurred within the time-window. In order to automatically generate a next time-window even in the absence of an echo pulse received in the previous time-window, an estimating circuit provides an estimated value for the time for generating the next time-window, which estimating circuit includes an envelope detector and a level detector for determining the time tL when the level of the envelope of the analog echo signal exceeds a predetermined level. The time for generating the next time-window is set at l/FR1/2FUS after the time tL if no echo pulse has occurred within the time-window.
5242455 IMAGING FIXATION AND LOCALIZATION SYSTEM Joseph L Skeens, Linda M Miketic assigned to University of Pittsburgh
The present invention relates to a method and apparatus for leision localiztion and stereotactic placement of probes into the body utilizing an imaging system such as magnetic resonance imaging or computerized tomography. Localization of the probe with reference to the device itself is accomplished by providing a base which includes a base localization grid and at least one localizing side member which includes a side localization grid. Extremely accurate placement of the probe within the body is accomplished by providing a spanning member to which a probe holder is attached. The spanning member is designed so as to be attachable to the base at any angle in the sag&al plane with respect to the base. The stereotactic device is assembled from materials having relatively low radiodensity to be substantially transparent to the form of energy used to generate the image used for probe guidance. By constructing the device from such materials and enabling the spanning member to be oriented at any angle with respect to the base, the device ensures that the probe remains within the same CT or MRI image so that it is easy to determine needle placement in any rescan. The stereotactic device also preferably includes a precompression means to compress soft tissue in the area of the probe entry point before penetration. The precompression means minimizes mislocation of the probe resulting from soft tissue compression. A respiration feedback means which directly measure respiratory volume is also preferably provided to enable a patient upon whom a biopsy or diagnostic procedure is being performed to control the patient’s degree of respiration. The feedback means can thus ensure that each scan is taken in the same phase of respiration.
5242681 LIPOPHILIC CONTRAST AGENTS FOR DIAGNOSTIC IMAGE ANALYSIS Gabriel A Elgavish, Sung K Kim assigned to Research Corporation Technologies Inc The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.
New Patents other, they respectively generate circularlypolarized high-frequency magnetic fields in the examination volume which are in-phase. In a reception mode, the signals induced in the diagonally disposed coils are superimposed inphase.
5241515 METHOD AND DEVICE FOR DETERMINING VARIATIONS IN THE POSITION OF A MOVABLE OBJECT BY MEANS OF ULTRASOUND Edwin Harms, Willem Prins, Groningen, Netherlands assigned to U S Philips Corp Variations in the position of a part of a living object within the measurement space of magnetic resonance apparatus are determined by an ultrasound device in which bursts of ultrasonic waves having a frequency FUS are transmitted towards the object in response to start signals generated to the repetition frequency FR, and ultrasonic waves reflected by the object are received and an analog echo signal is detected which is converted into a digital echo signal made up of a sequence of echo pulses having a repetition frequency FUS. The device includes a controller for generating a time-window, for determining whether a predetermined edge of an echo pulse occurs within the time-window, and for setting the time for generating the next timewindow at l/FR-1/2FUS after an echo pulse has occurred within the time-window. In order to automatically generate a next time-window even in the absence of an echo pulse received in the previous time-window, an estimating circuit provides an estimated value for the time for generating the next time-window, which estimating circuit includes an envelope detector and a level detector for determining the time tL when the level of the envelope of the analog echo signal exceeds a predetermined level. The time for generating the next time-window is set at l/FR1/2FUS after the time tL if no echo pulse has occurred within the time-window.
5242455 IMAGING FIXATION AND LOCALIZATION SYSTEM Joseph L Skeens, Linda M Miketic assigned to University of Pittsburgh
The present invention relates to a method and apparatus for leision localiztion and stereotactic placement of probes into the body utilizing an imaging system such as magnetic resonance imaging or computerized tomography. Localization of the probe with reference to the device itself is accomplished by providing a base which includes a base localization grid and at least one localizing side member which includes a side localization grid. Extremely accurate placement of the probe within the body is accomplished by providing a spanning member to which a probe holder is attached. The spanning member is designed so as to be attachable to the base at any angle in the sag&al plane with respect to the base. The stereotactic device is assembled from materials having relatively low radiodensity to be substantially transparent to the form of energy used to generate the image used for probe guidance. By constructing the device from such materials and enabling the spanning member to be oriented at any angle with respect to the base, the device ensures that the probe remains within the same CT or MRI image so that it is easy to determine needle placement in any rescan. The stereotactic device also preferably includes a precompression means to compress soft tissue in the area of the probe entry point before penetration. The precompression means minimizes mislocation of the probe resulting from soft tissue compression. A respiration feedback means which directly measure respiratory volume is also preferably provided to enable a patient upon whom a biopsy or diagnostic procedure is being performed to control the patient’s degree of respiration. The feedback means can thus ensure that each scan is taken in the same phase of respiration.
5242681 LIPOPHILIC CONTRAST AGENTS FOR DIAGNOSTIC IMAGE ANALYSIS Gabriel A Elgavish, Sung K Kim assigned to Research Corporation Technologies Inc The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.