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5256415 Vaccine against bovine respiratory disease (Pasteurellosis)
New Patents
VI
5256415
produce antibodies for passive immunotherapy, alone or in conjunction with active immunotherapy, in individuals infected with a retrovirus, including HIV, preferably those individuals exhibiting low levels of antibodies to retroviral gene products other than the outer envelope.
VACCINE AGAINST BOVINE RESPIRATORY DISEASE (PASTEURELLOSIS) Richard E Corstvet, Fred Enright Louisiana State University
assigned
to
A vaccine against bovine respiratory disease is provided containing an attenuated strain of Pasteurella haemolytica isolated from an asymptomatic calf. The vaccine effectively triggers an immunological system response to whole cell, denuded, cytotoxin and capsular antigens.
5256539 METHOD OF SCREENING FOR INFERTILITY OF SPERM Richard A Bronson assigned to The Research Foundation of State University of New York A method for detecting the presence of infertility in mammalian male animals based upon failure of sperm to undergo successful capacitation. Sperm samples are given the opportunity to undergo capacitation and subsequently contacted with antibodies to fibronectin. Binding levels indicate the degree of capacitation and consequently the presence of infertility.
5256767 RETROVIRAL
ANTIGENS
Jonas Salk, Dennis J Carlo assigned mune Response Corporation
to The Im-
The present invention provides a non-infectious immunotherapeutic containing retroviral particles devoid of outer envelope proteins or containing selected antigens isolated from a retrovirus. There is also provided a vaccine effective against HIV. In one aspect, the immunogen is useful for immunizing an individual previously infected by a retrovirus including HIV, so as to induce immunoprotective factors protective against progression of the infection. In another aspect, the vaccine is useful for vaccinating an individual not previously infected with HIV in order to prevent subsequently acquired infection. In another aspect, there is provided a method of rendering a viral immunogen noninfectious. The immunogen may also be used to
5268170 METHODS OF TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES, ESPECIALLY ARTHRITIC CONDITIONS Willem Van Eden, Jelle E R Thole, Johannes D A Van Embden, Zee Ruurd Van Der, Irun R Cohen, Bilthoven, Netherlands assigned to YEDA Research and Development Co Ltd A Mycobacterium bovis BCG polypeptide having a molecular mass of about 64 kD was found to be useful as an immunogen inducing resistance to autoimmune arthritis and similar autoimmune diseases. The invention relates to methods of treatment and diagnosis of autoimmune diseases especially arthritic conditions, in which said polypeptide is used. The invention also relates to a polypeptide comprising the epitope essential for this activity. The polypeptide has the formula See Patent for Chemical Structure ZOlYFVTDPERQEZl IAVLEDPYILL 221VSSKVSTVKD 23 1LLPLLEKVIG. Further, the invention relates to polypeptides showing sequential homology with said polypeptide, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer, form part of the invention. Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
5268382 MEDICAMENTS TO COMBAT AUTOIMMUNE DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATOSUS Robert R Bartlett, Rudolf Friedrich-Johannes Kammerer, Federal Republic Of Germany Hoechst Aktiengesellschaft
Schleyerbach, Darmstadt, assigned to
VI
5256415
produce antibodies for passive immunotherapy, alone or in conjunction with active immunotherapy, in individuals infected with a retrovirus, including HIV, preferably those individuals exhibiting low levels of antibodies to retroviral gene products other than the outer envelope.
VACCINE AGAINST BOVINE RESPIRATORY DISEASE (PASTEURELLOSIS) Richard E Corstvet, Fred Enright Louisiana State University
assigned
to
A vaccine against bovine respiratory disease is provided containing an attenuated strain of Pasteurella haemolytica isolated from an asymptomatic calf. The vaccine effectively triggers an immunological system response to whole cell, denuded, cytotoxin and capsular antigens.
5256539 METHOD OF SCREENING FOR INFERTILITY OF SPERM Richard A Bronson assigned to The Research Foundation of State University of New York A method for detecting the presence of infertility in mammalian male animals based upon failure of sperm to undergo successful capacitation. Sperm samples are given the opportunity to undergo capacitation and subsequently contacted with antibodies to fibronectin. Binding levels indicate the degree of capacitation and consequently the presence of infertility.
5256767 RETROVIRAL
ANTIGENS
Jonas Salk, Dennis J Carlo assigned mune Response Corporation
to The Im-
The present invention provides a non-infectious immunotherapeutic containing retroviral particles devoid of outer envelope proteins or containing selected antigens isolated from a retrovirus. There is also provided a vaccine effective against HIV. In one aspect, the immunogen is useful for immunizing an individual previously infected by a retrovirus including HIV, so as to induce immunoprotective factors protective against progression of the infection. In another aspect, the vaccine is useful for vaccinating an individual not previously infected with HIV in order to prevent subsequently acquired infection. In another aspect, there is provided a method of rendering a viral immunogen noninfectious. The immunogen may also be used to
5268170 METHODS OF TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES, ESPECIALLY ARTHRITIC CONDITIONS Willem Van Eden, Jelle E R Thole, Johannes D A Van Embden, Zee Ruurd Van Der, Irun R Cohen, Bilthoven, Netherlands assigned to YEDA Research and Development Co Ltd A Mycobacterium bovis BCG polypeptide having a molecular mass of about 64 kD was found to be useful as an immunogen inducing resistance to autoimmune arthritis and similar autoimmune diseases. The invention relates to methods of treatment and diagnosis of autoimmune diseases especially arthritic conditions, in which said polypeptide is used. The invention also relates to a polypeptide comprising the epitope essential for this activity. The polypeptide has the formula See Patent for Chemical Structure ZOlYFVTDPERQEZl IAVLEDPYILL 221VSSKVSTVKD 23 1LLPLLEKVIG. Further, the invention relates to polypeptides showing sequential homology with said polypeptide, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer, form part of the invention. Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
5268382 MEDICAMENTS TO COMBAT AUTOIMMUNE DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATOSUS Robert R Bartlett, Rudolf Friedrich-Johannes Kammerer, Federal Republic Of Germany Hoechst Aktiengesellschaft
Schleyerbach, Darmstadt, assigned to