5264204 Hydrophilic free radicals for magnetic resonance imaging

New Patents

5262945 METHOD FOR QUANTIFICATION OF BRAIN VOLUME FROM MAGNETIC RESONANCE IMAGES Charle DeCarli, Barry Horwitz assigned to The United States of America as represented by the Department of Health and Human Services A simple, rapid and semi-automated method of MRI analysis based on mathematical modelling of MRI pixel intensity histograms. The method is accurate and reliable for regional analysis of brain, central and subarachnoid CSF volumes. The method can be used to reveal significant agerelated changes in regional brain volumes which cannot be determined utilizing traced central CSF volumes or subarachnoid CSF volumes. The method can be used to quantify brain structure in healthy aging and brain disease.

5263482 THERMOGRAPHIC

IMAGING

Ib Leunbach, Drag Denmara Nycomed Innovation AB

assigned

to

There is provided a method of and apparatus for thermographic imaging involving the use in elecenhanced magnetic spin resonance tron resonance imaging (ESREMRI) of a paramagnetic contrast agent having in its esr spectrum a temperature dependant transition. The ESREMRI enhancement of the free induction decay signal resultant on stimulating that transition with radiation of a set frequency or frequency band is itself accordingly temperature dependant.

5264204 HYDROPHILIC FREE RADICALS FOR MAGNETIC RESONANCE IMAGING William P Cacheris, T Jeffre Dunn, Lynn delearie, Youlin Lin, Jeffrey Levine assigned to Mallinckrodt Medical Inc Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as

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magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention include stable hydrophilic free radicals having a hydrophilic moiety, such as polyhydroxyalkyl groups and heterocyclic amino-alcohols such as dihydroxypyrrolidine, dihydroxypiperidine, and trihyand a stable free radical droxypiperidine, moiety, such as a nitroxide, phenoxy, or phenoxazinyl free radical moiety.

5266896 MECHANICAL DETECTION AND IMAGING OF MAGNETIC RESONANCE BY MAGNETIC MOMENT MODULATION Daniel Rugar, John A Sidles, Costantino S Yanto International Business noni assigned Machines Corporation Methods and apparatus for detecting (and, if desired, imaging) the effects of magnetic resonance in a spin-containing material by measuring the magnetic force acting on a mechanical cantilever having a low damping coefficient due to modulation of the magnetic moment of the material in the polarizing field direction at a frequency substantially lower than the spin resonance frequency. Modulation of the magnetic moment in the direction of the polarizing magnetic field may be achieved by modulating (i) the magnitude of the magnetic field in the polarizing direction or (ii) the frequency or amplitude of a high-frequency magnetic field.

5266898 MAGNETIC RESONANCE IMAGING APPARATUS Mineyuki Konishi, Ootawara, Japan assigned to Kabushiki Kaisha Toshiba In a magnetic resonance imaging apparatus, a radio-frequency shielding body, which is disposed between the gradient magnetic field generating coils and the radio-frequency coil for interrupting electromagnetic coupling between the gradient magnetic field generating coils and the radio-frequency coil due to the radiofrequency pulse applied to the radio-frequency coil, is formed of a conductive material having a thickness less than the skin depth defined by See