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5278297 Gene encoding a novel protein H capable of binding to IgG
PATENT ABSTRACTS
561
5278297
The invention described encompasses an isolated D N A sequence encoding all or a portion thereof of a cell surface receptor for murine and human erythropoietin (hereinafter EPO-R), along with the isolated polypeptide expressed by the DNA sequence (i.e., isolated EPO-R). The invention also encompasses host cells containing the above-described DNA sequence, preferably, host cells which express the polypeptide encoded by the D N A sequence (EPO-R) at a significantly higher level than that produced by normal red blood cell precursors. The invention further encompasses D N A sequences encoding secreted forms of the human EPO-R and polypeptides corresponding thereto. The EPO-receptor in all of the disclosed forms can be used as models for designing drugs or in pharmaceutical compositions for treating anemias.
Hideyuki Gomi, Tatsunobu Hozumi, Shizuo Hattori, Chiaki Tagawa, Fumitaka Kishimoto, Lars Bjorck, Osaka, Japan assigned to Sumitomo Pharmaceuticals Company Ltd; HighTech Receptor
5278066
5278298
MOLECULAR CLONING AND EXPRESSION OF GENE ENCODING LIPOLYTIC ENZYME Peter M Andreoli, Maria M Cox, Farrokh Faiin, Rotterdam, Netherlands assigned to Gistbrocades NV Novel microbial host strains are provided which are transformed by a vector molecule comprising a DNA fragment encoding a lipolytic enzyme and a marker for selection, capable of producing active lipase. Said D N A fragment is preferably derived from a Pseudomonas species.
5278285 VARIANT OF KUNITZ-TYPE INHIBITOR DERIVED FROM THE ALPHA3-CHAIN OF HUMAN TYPE VI COLLAGEN PRODUCED BY RECOMBINANT DNA TECHNOLOGY Juergen Ebbers, Dietrich Hoerlein, Ruppert Timpl, Mon-Li Chu, Wuppertal, Federal Republic Of Germany assigned to Bayer Aktiengesellschaft Kunitz-type inhibitor derived from the alpha3chain of human type VI collagen produced by recombinant DNA technology, variants thereof, process, expression vector and recombinant host therefore and pharmaceutical use thereof are disclosed.
GENE ENCODING A NOVEL PROTEIN H CAPABLE OF BINDING TO IGG
A gene coding for Protein H, which is capable of binding specifically to human IgG of all subclasses, was isolated from Streptococcus sp. AP 1 and expressed in host cells, E. coli to produce the Protein H.
EIMERIA
BRUNETTI PROBES
16S R D N A
Prasanta R Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D Feighner, Paul A Liberator, Helen Profous-Juchelka assigned to Merck & Co lnc Unique species-specific Eimeria brunetti DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria brunetti.
5279938 SENSITIVE DIAGNOSTIC TEST FOR LYME DISEASE Patricia A Rosa assigned to The United States of America as represented by the Department of Health and Human Services The nucleotide sequence of a recombinant clone containing a specific segment of Borrelia burgdorferi DNA which enables the identification of the spirochetes causing Lyme disease has been provided. A diagnostic kit containing oligonucleotide primers derived from this sequence, suitable for the detection of Borrelia burgdoferi in a PCR assay, as well as the cloned DNA of the present invention, allows the detection of Lyme disease with sensitivity and specificity not heretofore attained by any other test.
561
5278297
The invention described encompasses an isolated D N A sequence encoding all or a portion thereof of a cell surface receptor for murine and human erythropoietin (hereinafter EPO-R), along with the isolated polypeptide expressed by the DNA sequence (i.e., isolated EPO-R). The invention also encompasses host cells containing the above-described DNA sequence, preferably, host cells which express the polypeptide encoded by the D N A sequence (EPO-R) at a significantly higher level than that produced by normal red blood cell precursors. The invention further encompasses D N A sequences encoding secreted forms of the human EPO-R and polypeptides corresponding thereto. The EPO-receptor in all of the disclosed forms can be used as models for designing drugs or in pharmaceutical compositions for treating anemias.
Hideyuki Gomi, Tatsunobu Hozumi, Shizuo Hattori, Chiaki Tagawa, Fumitaka Kishimoto, Lars Bjorck, Osaka, Japan assigned to Sumitomo Pharmaceuticals Company Ltd; HighTech Receptor
5278066
5278298
MOLECULAR CLONING AND EXPRESSION OF GENE ENCODING LIPOLYTIC ENZYME Peter M Andreoli, Maria M Cox, Farrokh Faiin, Rotterdam, Netherlands assigned to Gistbrocades NV Novel microbial host strains are provided which are transformed by a vector molecule comprising a DNA fragment encoding a lipolytic enzyme and a marker for selection, capable of producing active lipase. Said D N A fragment is preferably derived from a Pseudomonas species.
5278285 VARIANT OF KUNITZ-TYPE INHIBITOR DERIVED FROM THE ALPHA3-CHAIN OF HUMAN TYPE VI COLLAGEN PRODUCED BY RECOMBINANT DNA TECHNOLOGY Juergen Ebbers, Dietrich Hoerlein, Ruppert Timpl, Mon-Li Chu, Wuppertal, Federal Republic Of Germany assigned to Bayer Aktiengesellschaft Kunitz-type inhibitor derived from the alpha3chain of human type VI collagen produced by recombinant DNA technology, variants thereof, process, expression vector and recombinant host therefore and pharmaceutical use thereof are disclosed.
GENE ENCODING A NOVEL PROTEIN H CAPABLE OF BINDING TO IGG
A gene coding for Protein H, which is capable of binding specifically to human IgG of all subclasses, was isolated from Streptococcus sp. AP 1 and expressed in host cells, E. coli to produce the Protein H.
EIMERIA
BRUNETTI PROBES
16S R D N A
Prasanta R Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D Feighner, Paul A Liberator, Helen Profous-Juchelka assigned to Merck & Co lnc Unique species-specific Eimeria brunetti DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria brunetti.
5279938 SENSITIVE DIAGNOSTIC TEST FOR LYME DISEASE Patricia A Rosa assigned to The United States of America as represented by the Department of Health and Human Services The nucleotide sequence of a recombinant clone containing a specific segment of Borrelia burgdorferi DNA which enables the identification of the spirochetes causing Lyme disease has been provided. A diagnostic kit containing oligonucleotide primers derived from this sequence, suitable for the detection of Borrelia burgdoferi in a PCR assay, as well as the cloned DNA of the present invention, allows the detection of Lyme disease with sensitivity and specificity not heretofore attained by any other test.