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5359037 Antibodies to TNF binding protein I
PATENT ABSTRACTS
754
indulyl- beta-D-galactepyranoside which produces an indigo blue precipitate when reactedupon by beta-galactosidase may be used with one of the novel compounds 6-chloroindolyl- beta-Dghicuronide, 4,6-dichloroindolyl- beta-Dglucuronide, 6,7-dichloroindolyl- beta-Dghicuronide, and 4,6,7-trichloroindolyl- beta-Dglucuronide, which produce mauve or magenta precipitates when reacted upon by betaglucuronidase. The beta-glucuronidase substrate 5-bromo-4-chloro-3-indolyl- beta-D-ghicuronide, which produces an indigo blue precipitate when reacted upon by beta-glucuronidase may be used with one of the novel compounds 6-chloroindolylbeta-D-galactoside, 4,6-dichloroindolyl- beta-Dgalactoside, 6,7-dichloroindolyl- beta-Dgalactoside, and 4,6,7-txichloroindolyl- beta-Dgalactoside which produce mauve or magenta precipitates when reacted upon by betagalactosidase.
Apparatus for growing cells or tissue in vitro and for supporting, positioning and/or centering cell culture inserts that are used in such procedures. The apparatus comprises a body with a plurality of wells wherein a cell culture insert may be supported and centered without interfering with the growing of tissue culture in vitro.
5358855
Cate Richard L; Pepiasky R Blak Cambridge, MA, UNITED STATES Assigned to Biogen lnc
INOSINIC ACID DEHYDROGENASE ASSAY Markovic Olivera T; Markovic Neuad; Roberts Jay; Puglia Charles; Markovic Svetomir N Philadelphia, PA, UNITED STATES Assigned to The Medical College of Pennsylvania A cyto(histo)chemical technique for determining inosine 5'-monophc*phate dehydrogenase (IMPD) presence and concentration within one or more morphologically classified or classifiable cells taken from an animal or a human subject. Cell monolayers are prepared, fixed and stained according to a specified procedure in which inosine 5'-monophosphate (as enzyme substrate), nicotinamide adenine dinucleotide (NAD), phenazine methosulfate (PMS) and nitro blue tetrazolium (NBT) as a diazonium salt together produce a granular, dark blue deposit of formazan generally proportional to the IMPD activity in the cell. Cells are evaluated either visually or by image analysis, with a computerized image analyzer or other imaging system, according to accepted biostatistical methods and standards.
5358871
5359033 CLEAVED DIMERS OF MULLERIAN INHIBITING SUBSTANCE-LIKE POLYPEPTIDES
PCT No. PCT/US89/00239 Sec. 371 Date Jul. 23, 1990 Sec. 102(e) Date Jul. 23, 1990 PCT Filed Jan. 25, 1989 PCT Pub. No. WO89/06695 PCT Pub. Date Jul. 27, 1989.This invention relates to cleaved dimers of Mullerian inhibiting substancelike polypeptides. More particularly, this invention relates to such dimers, methods of producing them and methods of using them in the treatment of cancer and tumors, especially those of the female genital tract. The dimers of this invention are also useful in compositions and methods for contraception.
5359037 ANTIBODIES TO TNF BINDING PROTEIN I
CULTURE VESSEL
Wallach David; Engelmann Hartmut; Aderka Dan Rehovot, ISRAEL Assigned to Yeda Research and Development Co Ltd
Stevens Timothy A; Mussi Edward F; Henderson Douglas P; Tyndorf Tadeusz Madison, N J, UNITED STATES Assigned to Becton Dickinson and Company
Antibodies to TNF Binding Protein I frBP-l) are provided that can be used in diagnostic assays and as pharmaceutical agents for either inhibiting or mimicking the effects of TNF on cells.
754
indulyl- beta-D-galactepyranoside which produces an indigo blue precipitate when reactedupon by beta-galactosidase may be used with one of the novel compounds 6-chloroindolyl- beta-Dghicuronide, 4,6-dichloroindolyl- beta-Dglucuronide, 6,7-dichloroindolyl- beta-Dghicuronide, and 4,6,7-trichloroindolyl- beta-Dglucuronide, which produce mauve or magenta precipitates when reacted upon by betaglucuronidase. The beta-glucuronidase substrate 5-bromo-4-chloro-3-indolyl- beta-D-ghicuronide, which produces an indigo blue precipitate when reacted upon by beta-glucuronidase may be used with one of the novel compounds 6-chloroindolylbeta-D-galactoside, 4,6-dichloroindolyl- beta-Dgalactoside, 6,7-dichloroindolyl- beta-Dgalactoside, and 4,6,7-txichloroindolyl- beta-Dgalactoside which produce mauve or magenta precipitates when reacted upon by betagalactosidase.
Apparatus for growing cells or tissue in vitro and for supporting, positioning and/or centering cell culture inserts that are used in such procedures. The apparatus comprises a body with a plurality of wells wherein a cell culture insert may be supported and centered without interfering with the growing of tissue culture in vitro.
5358855
Cate Richard L; Pepiasky R Blak Cambridge, MA, UNITED STATES Assigned to Biogen lnc
INOSINIC ACID DEHYDROGENASE ASSAY Markovic Olivera T; Markovic Neuad; Roberts Jay; Puglia Charles; Markovic Svetomir N Philadelphia, PA, UNITED STATES Assigned to The Medical College of Pennsylvania A cyto(histo)chemical technique for determining inosine 5'-monophc*phate dehydrogenase (IMPD) presence and concentration within one or more morphologically classified or classifiable cells taken from an animal or a human subject. Cell monolayers are prepared, fixed and stained according to a specified procedure in which inosine 5'-monophosphate (as enzyme substrate), nicotinamide adenine dinucleotide (NAD), phenazine methosulfate (PMS) and nitro blue tetrazolium (NBT) as a diazonium salt together produce a granular, dark blue deposit of formazan generally proportional to the IMPD activity in the cell. Cells are evaluated either visually or by image analysis, with a computerized image analyzer or other imaging system, according to accepted biostatistical methods and standards.
5358871
5359033 CLEAVED DIMERS OF MULLERIAN INHIBITING SUBSTANCE-LIKE POLYPEPTIDES
PCT No. PCT/US89/00239 Sec. 371 Date Jul. 23, 1990 Sec. 102(e) Date Jul. 23, 1990 PCT Filed Jan. 25, 1989 PCT Pub. No. WO89/06695 PCT Pub. Date Jul. 27, 1989.This invention relates to cleaved dimers of Mullerian inhibiting substancelike polypeptides. More particularly, this invention relates to such dimers, methods of producing them and methods of using them in the treatment of cancer and tumors, especially those of the female genital tract. The dimers of this invention are also useful in compositions and methods for contraception.
5359037 ANTIBODIES TO TNF BINDING PROTEIN I
CULTURE VESSEL
Wallach David; Engelmann Hartmut; Aderka Dan Rehovot, ISRAEL Assigned to Yeda Research and Development Co Ltd
Stevens Timothy A; Mussi Edward F; Henderson Douglas P; Tyndorf Tadeusz Madison, N J, UNITED STATES Assigned to Becton Dickinson and Company
Antibodies to TNF Binding Protein I frBP-l) are provided that can be used in diagnostic assays and as pharmaceutical agents for either inhibiting or mimicking the effects of TNF on cells.