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5364781 Process for preparing daunorubicin
PATENT ABSTRACTS detected in the receptor, a sequence which promotes recombination,and/or a hairpin structure at one or both ends. The transformation process uses donor DNA coupled to the multifunctional linker and allows for early success followed by further characterization of the donor DNA and its phenotypic impact.
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restriction sites shown in FIGS. 2, 3 & 4 and nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O- methyltransferase.
5364782 5364780 E X T E R N A L R E G U L A T I O N OF GENE EXPRESSION BY INDUCIBLE P R O M O T E R S Hershey Howard P; Katayama Carol D; Ralston Edward J; Stoner Timothy D; Wong James - E I Du Pont de Nemours and Company PCT No. PCT/US90/01210 Sec. 371 Date Jul. 31, 1991 Sec. 102(e) Date Jul. 31, 1991 PCT Filed Mar. 14, 1990.The preparation and use of nucleic acid promoter fragments derived from several genes from corn, petunia and tobacco which are highly responsive to a number of substituted benzenesulfonamides and related compounds are described. These promoter fragments are useful in creating recombinant DNA constructions comprising nucleic acid sequences encoding any desired gene product operably linked to such promoter fragments which can be utilized to transform plants and bring the expression of the gene product under external chemical control in various tissues of monocotyledonous and dicotyledonous plants.
M U T A N T MICROBIAL ALPHAA M Y L A S E S WITH INCREASED T H E R M A L , ACID AND/OR A L K A L I N E STABILITY Quax Wilhelmus J; Laroche Yves; Vollebregt Adrianus W H; Stanssens Patrick; Lauwereys Marc - Gist-Brocades N V; Plant Genetic Systems N PCT No. PCT/EP90/01042 Sec. 371 Date Dec. 2, 1990 Sec. 102(e) Date Dec. 2, 1990 PCT Filed Jun. 27, 1990 PCT Pub. No. WO91/00353 PCT Pub. Date Jan. 10, 1991.Thermostable and acid stable alpha-amylases are provided as expression products of genetically engineered alpha-amylase genes isolated from microorganisms, preferably belonging to the class of Bacilli. Both chemical and enzymatic mutagenesis methods are e.g. the bisulphite method and enzymatic misincorporation on gapped heteroduplex DNA. The mutant alphaamylases have superior properties, e.g. improved thermostability over a broad pH range, for industrial application in starch processing and textile desizing.
5364783 5364781 PROCESS FOR PREPARING DAUNORUBICIN Hutchinson Charles R; Madduri Krishna M; Torti Francesca; Colombo Anna L - Farmitalia Carlo ERBA S r 1 The ability to convert carmJnomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of
RETROVIRUS PROMOTER-TRAP VECTORS Ruley H Earl; von Melchner Harold Massachusetts Institute of Technology Retroviruses are used as genetic tools to isolate transcriptionally active chromosomal regions. The retroviruses have a promoterless protein coding sequence located in U3 or U5. The retroviruses may be used to infect cells under conditions which permit selection for instances when the retrovirus integrates in close proximity to and under the
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restriction sites shown in FIGS. 2, 3 & 4 and nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O- methyltransferase.
5364782 5364780 E X T E R N A L R E G U L A T I O N OF GENE EXPRESSION BY INDUCIBLE P R O M O T E R S Hershey Howard P; Katayama Carol D; Ralston Edward J; Stoner Timothy D; Wong James - E I Du Pont de Nemours and Company PCT No. PCT/US90/01210 Sec. 371 Date Jul. 31, 1991 Sec. 102(e) Date Jul. 31, 1991 PCT Filed Mar. 14, 1990.The preparation and use of nucleic acid promoter fragments derived from several genes from corn, petunia and tobacco which are highly responsive to a number of substituted benzenesulfonamides and related compounds are described. These promoter fragments are useful in creating recombinant DNA constructions comprising nucleic acid sequences encoding any desired gene product operably linked to such promoter fragments which can be utilized to transform plants and bring the expression of the gene product under external chemical control in various tissues of monocotyledonous and dicotyledonous plants.
M U T A N T MICROBIAL ALPHAA M Y L A S E S WITH INCREASED T H E R M A L , ACID AND/OR A L K A L I N E STABILITY Quax Wilhelmus J; Laroche Yves; Vollebregt Adrianus W H; Stanssens Patrick; Lauwereys Marc - Gist-Brocades N V; Plant Genetic Systems N PCT No. PCT/EP90/01042 Sec. 371 Date Dec. 2, 1990 Sec. 102(e) Date Dec. 2, 1990 PCT Filed Jun. 27, 1990 PCT Pub. No. WO91/00353 PCT Pub. Date Jan. 10, 1991.Thermostable and acid stable alpha-amylases are provided as expression products of genetically engineered alpha-amylase genes isolated from microorganisms, preferably belonging to the class of Bacilli. Both chemical and enzymatic mutagenesis methods are e.g. the bisulphite method and enzymatic misincorporation on gapped heteroduplex DNA. The mutant alphaamylases have superior properties, e.g. improved thermostability over a broad pH range, for industrial application in starch processing and textile desizing.
5364783 5364781 PROCESS FOR PREPARING DAUNORUBICIN Hutchinson Charles R; Madduri Krishna M; Torti Francesca; Colombo Anna L - Farmitalia Carlo ERBA S r 1 The ability to convert carmJnomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of
RETROVIRUS PROMOTER-TRAP VECTORS Ruley H Earl; von Melchner Harold Massachusetts Institute of Technology Retroviruses are used as genetic tools to isolate transcriptionally active chromosomal regions. The retroviruses have a promoterless protein coding sequence located in U3 or U5. The retroviruses may be used to infect cells under conditions which permit selection for instances when the retrovirus integrates in close proximity to and under the