5366728 Stable forms of antigenic taenia ovis polypeptides

PATENT ABSTRACTS A method of increasing sterol accumulation in a plant by increasing the copy number of a gene encoding a polypeptide having HMG-CoA reductase activity is disclosed. The copy number is preferably increased by transforming plants with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMGCoA reductase activity, and a promoter suitable for driving the expression of said polypeptide. Also disclosed are a method of increasing cycloartenol accumulation in a plant, a method of increasing the resistance of plants to pests and the transformed plants themselves.

5366728

85

EC-SOD and having a modified (reduced or increased) binding to heparin as compared to recombinant EC-SOD C as well as compositions comprising such variants. The EC-SOD variants are polypeptides comprising: 1) amino acids 1- 193 of native EC-SOD C and 2) an amino acid sequence which is based on, but different from amino acid moieties 194-222 of recombinant ECSOD C, either by being truncated or prolonged at the C-terminal end or by having substituted or otherwise modified one or more amino acid moieties of the sequence. Another EC-SOD variant is one which differs from recombinant ECSOD C by being a glycosylation-free mutant. The variants may be produced by recombinant DNA techniques and are useful in the treatment of various diseases.

STABLE F O R M S OF ANTIGENIC TAENIA OVIS P O L Y P E P T I D E S Harrison Gavin B; Dempster Robert P; Rickard Michael D; Lightowlers Marshall; Heath David D; Lawrence Stephen; O'Hoy Kim L - Pitman-Moore New Zealand Limited; The University of MelbourneHer Majestry the Queen in right of New Zealand through the Ministry of Agriculture & Fisheri Stable forms of Taenia ovis peptide antigens, such as portions of a T. ovis oncosphere antigen which runs as a 47-52 kDa doublet, are suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obtained by isolation and expression of the DNA encoding them in recombinant host cells. Aspects of the invention include DNA encoding T. ovis antigens, vectors containing such DNA and host cells which express the T. ovis antigens.

5366729 NON-GLYCOSYLATED V A R I A N T S OF E X T R A C E L L U L A R S U P E R O X I D E D I S M U T A S E (EC-

5366860 SPECTRALLY RESOLVABLE R H O D A M I N E DYES FOR NUCLEIC ACID S E Q U E N C E DETERMINATION Bergot B John; Chakerian Vergin; Connell Charles R; Eadie J Scot; Fung Steven; Hershey N Davi; Lee Linda G; Menchen Steven M;Woo Sam L - Applied Biosystems Inc A spectrally resolvable set of rhodamine dyes are provided for use in the chain termination method of nucleic acid sequencing. A different rhodamine dye from the group consisting of tetramethylrhodamine, rhodamine X, rhodamine 6G, and rhodamine 110 is attached to the base of each of the dideoxynucleotides used in the sequencing method by way of an alkynylamino linker. Preferably, the labeled dideoxynucleotides are incorporated into the growing DNA chains by Taq DNA polymerase.

SOD)

5366862

Marklund Stefa; Edlund Thomas, Ume#522, SWEDEN - Symbicom Aktiebolag

M E T H O D FOR G E N E R A T I N G A N D SCREENING USEFUL PEPTIDES

PCT No. PCT/DK90/00238 Sec. 371 Date May 13, 1992 Sec. 102(e) Date May 13, 1992 PCT Filed Sep. 17, 1990 PCT Pub. No. WO91/04315 PCT Pub. Date Apr. 4, 1991.Extracellular superoxide dismutase (EC-SOD) variants having the superoxide dismutating property of the native

Venton Duane; Hopfinger Anton J; Le Breton Guy - Receptor Laboratories Inc The invention allows the generation and screening of a large population of peptides for the presence