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5374553 DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
793
PATENT ABSTRACTS Asp-Pro-Arg alpha-keto-amide derivatives, and their pharmaceutically acceptable salts and compositions, for use as antithrombotic agents in mammals are disclosed. The method of use of these inhibitor compounds for treatment or prevention of conditions of abnormal thrombus formation in mammals is also disclosed. Further disclosed are alpha-hydroxy amide compounds used as intermediates in the preparation of the keto-amide compounds.
complex is useful as an antibacterial agent against both Gram-positive and Gram-negative bacteria. The enzyme complex may be produced by cultivating the B. pabuli microorganisms in an aqueous medium containing cornsteep liquor, after which the lyric enzyme complex can be recovered from the fermentation broth.
5371074 5374553 USE OF SACCHARIN DERIVATIVES AS PROTEOLYTIC ENZYME INHIB1TORS Dunlap Richard P; Boaz Neil W; Mura Albert J; Hlasta Dennis J; Desai Ranjit C; Subramanyam Chakrapani; Latimer Lee H; Lodge Eric P Penfield' NY, UNITED STATES Assigned to Sterling Winthrop Inc Novel ?.-substituted saccharius which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula 0010 wherein: L is -O-, -S-, -SO- or -SO2-;m and n are each independently 0 or 1; RI is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or subs'timed heterocyclyl or, when L is -O- and n is 1, cycloheptatrienon-2-yi or, when L is -S- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is -SO2- and n is 1, Iower-alkyi or trifiuoromethyi; R2 is hydrogen, loweralkoxycarbonyl, pbenyl or pbenylthio; and R3 and R4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.
DNA ENCODING A THERMOSTABLE NUCLEIC ACID POLYMERASE ENZYME FROM THERMOTOGA MARITIMA Gelfand David H; Lawyer Frances C Oakland, CA, UNITED STATES Assigned to Hoffmann-La Roche Inc A purified thermostable enzyme is derived from the eubacterium Thermotoga maritima. The enzyme has a molecular weight of about 97 kilodaltons and DNA polymerase I activity. The enzyme can be produced from native or recombinant host cells and can be used with primers and nucleoside triphosphates in a temperaturecycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
5376536 GLUCOSE ISOMERASE ENZYMES AND THEIR USE
5374545 CELL WALL LYTIC ENZYMES FROM BACILLUS PABULI Liu Chi-L; Overholt Janet M Davis, CA, UNITED STATES Assigned to Novo Nordisk A/S A bacteriolytic enzyme complex is obtained from a bacterial culture of Bacillus p~uli strains, e.g., isolates 350-2 (NRRL B-18446) and 391-1 (NRRL B-18447). This bacteriolyfic enzyme
Quax Wilhemus; Luiten Rudolf G; Schuuxhuizen Paul; Mrabet Nadir VB Voorschoten, NETHERLANDS Assigned to Gist-Brocades N V; Plant Genetic Systems N V New mutant glucose isomerases are provided exhibiting improved properties under application conditions. These glucose isomerases are obtained by expression of a gene encoding said enzyme, having an amino acid sequence which differs at least in one amino acid from the wildtype glucose isomerase. Preferred mutant enzymes are those derived from Actinoplanes missouriensis glucose isomerase.
PATENT ABSTRACTS Asp-Pro-Arg alpha-keto-amide derivatives, and their pharmaceutically acceptable salts and compositions, for use as antithrombotic agents in mammals are disclosed. The method of use of these inhibitor compounds for treatment or prevention of conditions of abnormal thrombus formation in mammals is also disclosed. Further disclosed are alpha-hydroxy amide compounds used as intermediates in the preparation of the keto-amide compounds.
complex is useful as an antibacterial agent against both Gram-positive and Gram-negative bacteria. The enzyme complex may be produced by cultivating the B. pabuli microorganisms in an aqueous medium containing cornsteep liquor, after which the lyric enzyme complex can be recovered from the fermentation broth.
5371074 5374553 USE OF SACCHARIN DERIVATIVES AS PROTEOLYTIC ENZYME INHIB1TORS Dunlap Richard P; Boaz Neil W; Mura Albert J; Hlasta Dennis J; Desai Ranjit C; Subramanyam Chakrapani; Latimer Lee H; Lodge Eric P Penfield' NY, UNITED STATES Assigned to Sterling Winthrop Inc Novel ?.-substituted saccharius which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula 0010 wherein: L is -O-, -S-, -SO- or -SO2-;m and n are each independently 0 or 1; RI is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or subs'timed heterocyclyl or, when L is -O- and n is 1, cycloheptatrienon-2-yi or, when L is -S- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is -SO2- and n is 1, Iower-alkyi or trifiuoromethyi; R2 is hydrogen, loweralkoxycarbonyl, pbenyl or pbenylthio; and R3 and R4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.
DNA ENCODING A THERMOSTABLE NUCLEIC ACID POLYMERASE ENZYME FROM THERMOTOGA MARITIMA Gelfand David H; Lawyer Frances C Oakland, CA, UNITED STATES Assigned to Hoffmann-La Roche Inc A purified thermostable enzyme is derived from the eubacterium Thermotoga maritima. The enzyme has a molecular weight of about 97 kilodaltons and DNA polymerase I activity. The enzyme can be produced from native or recombinant host cells and can be used with primers and nucleoside triphosphates in a temperaturecycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
5376536 GLUCOSE ISOMERASE ENZYMES AND THEIR USE
5374545 CELL WALL LYTIC ENZYMES FROM BACILLUS PABULI Liu Chi-L; Overholt Janet M Davis, CA, UNITED STATES Assigned to Novo Nordisk A/S A bacteriolytic enzyme complex is obtained from a bacterial culture of Bacillus p~uli strains, e.g., isolates 350-2 (NRRL B-18446) and 391-1 (NRRL B-18447). This bacteriolyfic enzyme
Quax Wilhemus; Luiten Rudolf G; Schuuxhuizen Paul; Mrabet Nadir VB Voorschoten, NETHERLANDS Assigned to Gist-Brocades N V; Plant Genetic Systems N V New mutant glucose isomerases are provided exhibiting improved properties under application conditions. These glucose isomerases are obtained by expression of a gene encoding said enzyme, having an amino acid sequence which differs at least in one amino acid from the wildtype glucose isomerase. Preferred mutant enzymes are those derived from Actinoplanes missouriensis glucose isomerase.