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5378606 Specific detection of neisseria gonorrhoeae
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PATENT ABSTRACTS which confer positive transcription promotion to heterologous structural genes and promoters without conferring sterol responsivity. Methods are disclosed for employing these genetic control elements in a myriad of embodiments which provide for a fine-tune control of beterologous genes. Methods are also disclosed for employing the SRE in a screening assay for drugs capable of stimulating the cell to synthesize LDL receptors.
5378604 OLIGONUCLEOTIDE PROBES FOR DETECTION OF PERIODONTAL PATHOGENS Schwartz Dennis E; Kanemoto Roy H; Watanabe Susan M; Dix Ki Redmond, WA, UNITED STATES Assigned to MicroProbe Corporation This invention relates to compositions of oligonucleotide probes for use in the detection of bacteria associated with medical disorders of the human mouth, wherein said probes consist essentially of a segment of nucleic acid capable of selectively hybridizing under hybridizing conditions, to the 16S or 23S ribosomal RNA (rRNA) of said bacteria. Methods for detection, as well as diagnostic kits for the assay of these bacterium, are also disclosed.
5378605 METHOD OF DETECTING HEPATITIS B VARIANTS HAVING DELETIONS WITHIN THE X REGION OF THE VIRUS GENOME Feitelson Mark; Duan Ling-Xun; Guo Jianhui North Wales, PA, UNITED STATES Assigned to Thomas Jefferson University The present invention provides methods for the detection of hepatitis B virus in atypical infections by simultaneously detecting antibodies against the X and polymerase gene products of HBV. Further, the present invention provides methods for the detection of HBV in atypical infections in a polymerase chain reaction OaCR) assay employing selected primes. These primers allow the detection of a specific class of HBV variants. These methods are useful for demonstrating the presence of productive virus infection and may prove useful in monitoring therapeutics.
5378606 SPECIFIC DETECTION OF NEISSERIA GONORRHOEAE Stern Anne; Wolff Karin Penzberg, GERMANY Assigned to Boehringer Mannheim GmbH The present invention concerns a Neisseria gonorrhocae-specific nucleic acid probe which has at least one of the nucleic acid sequences shown in SEQ ID NO 1-15 as well as a method for the detection of the pathogenic Neisseria species N.gonerrhoeae using such a nucleic acid probe. The sequences shown in Sequence ID Nos. 1-15 correspond to or are complementary to partial regions of the 23S rRNA gene or to the spacer region located on the 3' side thereof.
5378612 CULTURE MEDIUM FOR PRODUCTION OF RECOMBINANT PROTEIN Nakashima Kazuyuki; Mimaki Izumi; Hamamoto Takayoshi; Masuda Keniehi Kumamoto, JAPAN Assigned to Juridical Foundation The ChemoSero-Therapeutic Research Institute; Teijin Limit A culture medium without or with a low level of protein for culturing a transformed animal cell capable of continuously producing a protein prepared by using a genetic engineering technique, which contains a nonionic surfactant and cyclodextrin, and a method for producing a protein which comprises culturing a transformed animal cell capable of producing the desired protein prepared by using a genetic engineering technique in the culture medium.
5378613 METHOD FOR INCREASED EXPRESSION OF LOW MOLECULAR WEIGHT RECOMBINANT POLYPEPTIDES Belagaje Rama M Indianapolis, IN, UNITED STATES Assigned to Eli Lilly and Company The present invention provides a method for increasing expression of low molecular weight
PATENT ABSTRACTS which confer positive transcription promotion to heterologous structural genes and promoters without conferring sterol responsivity. Methods are disclosed for employing these genetic control elements in a myriad of embodiments which provide for a fine-tune control of beterologous genes. Methods are also disclosed for employing the SRE in a screening assay for drugs capable of stimulating the cell to synthesize LDL receptors.
5378604 OLIGONUCLEOTIDE PROBES FOR DETECTION OF PERIODONTAL PATHOGENS Schwartz Dennis E; Kanemoto Roy H; Watanabe Susan M; Dix Ki Redmond, WA, UNITED STATES Assigned to MicroProbe Corporation This invention relates to compositions of oligonucleotide probes for use in the detection of bacteria associated with medical disorders of the human mouth, wherein said probes consist essentially of a segment of nucleic acid capable of selectively hybridizing under hybridizing conditions, to the 16S or 23S ribosomal RNA (rRNA) of said bacteria. Methods for detection, as well as diagnostic kits for the assay of these bacterium, are also disclosed.
5378605 METHOD OF DETECTING HEPATITIS B VARIANTS HAVING DELETIONS WITHIN THE X REGION OF THE VIRUS GENOME Feitelson Mark; Duan Ling-Xun; Guo Jianhui North Wales, PA, UNITED STATES Assigned to Thomas Jefferson University The present invention provides methods for the detection of hepatitis B virus in atypical infections by simultaneously detecting antibodies against the X and polymerase gene products of HBV. Further, the present invention provides methods for the detection of HBV in atypical infections in a polymerase chain reaction OaCR) assay employing selected primes. These primers allow the detection of a specific class of HBV variants. These methods are useful for demonstrating the presence of productive virus infection and may prove useful in monitoring therapeutics.
5378606 SPECIFIC DETECTION OF NEISSERIA GONORRHOEAE Stern Anne; Wolff Karin Penzberg, GERMANY Assigned to Boehringer Mannheim GmbH The present invention concerns a Neisseria gonorrhocae-specific nucleic acid probe which has at least one of the nucleic acid sequences shown in SEQ ID NO 1-15 as well as a method for the detection of the pathogenic Neisseria species N.gonerrhoeae using such a nucleic acid probe. The sequences shown in Sequence ID Nos. 1-15 correspond to or are complementary to partial regions of the 23S rRNA gene or to the spacer region located on the 3' side thereof.
5378612 CULTURE MEDIUM FOR PRODUCTION OF RECOMBINANT PROTEIN Nakashima Kazuyuki; Mimaki Izumi; Hamamoto Takayoshi; Masuda Keniehi Kumamoto, JAPAN Assigned to Juridical Foundation The ChemoSero-Therapeutic Research Institute; Teijin Limit A culture medium without or with a low level of protein for culturing a transformed animal cell capable of continuously producing a protein prepared by using a genetic engineering technique, which contains a nonionic surfactant and cyclodextrin, and a method for producing a protein which comprises culturing a transformed animal cell capable of producing the desired protein prepared by using a genetic engineering technique in the culture medium.
5378613 METHOD FOR INCREASED EXPRESSION OF LOW MOLECULAR WEIGHT RECOMBINANT POLYPEPTIDES Belagaje Rama M Indianapolis, IN, UNITED STATES Assigned to Eli Lilly and Company The present invention provides a method for increasing expression of low molecular weight