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5380833 Polynucleotide reagents containing selectable cleavage sites
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PATENT ABSTRACTS
rim portion (56) for holding the bottles (16), with each the grasping clamps (60) being paired with another on the opposing wheel (43) such that a bottle (16) may be supported by both wheels (43). The perimeter surface (58) of each wheel is beveled to facilitate agitation. The drive shaft (40) is caused to rotate by a drive motor (36) and a drive linkage (38) which cause the rotisserie assembly (14) to rotate about a rotational axis (41), thus transporting and agitating the samples within the oven cavity (28). The incubator (10) is primarily utilized for nucleotide hybridization procedures.
in vivo calcium transport activity with little or no bone calcium mobifization activity. These compounds thus show promise in the treatment of osteoporosis.
5380833 POLYNUCLEOTIDE REAGENTS CONTAINING SELECTABLE CLEAVAGE SITES Urdea Michael S Alamo, CA, UNITED STATES Assigned to Chiton Corporation
5380712 TRUNCATED HUMAN SERUM ALBUMIN POLYPEPTIDES AS PLASMA EXPANDING AGENTS Ballance David J; Hinchliffe Edward; Geisow
Michael J; Senior Peter Attenborough, UNITED KINGDOM Assigned to Delta Biotechnology Limited Polypeptides corresponding to mature human serum albumin residues 1 to n, where n is between 369 and 419 inclusive, are useful as substitutes for albumin in the treatment of burns and shock in humans, the clearance of undesirable compounds, (such as bilirubin) from human blood, in laboratory growth media and in HSA assays. The polypep*ides may be produced by recombinant DNA techniques, especially in yeast.
Novel methods for assaying a nucleic acid analyte are provided, which employ polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest in the analyte, where the presence or absence of hybddiza*ion at a predetermined stringency provides for the release of a label from a support. Particularly, various techniques are employed for binding a label to a support, whereupon cleavage of either a single or double strand, a label may be released from a support,where the release of the label can be detected as indicative of the presence of a particular oligonucleotide sequence in a sample. The method finds use in diagnosis of disease, genetic monitoring, and analysis of nucleic acid mixtures.
5380836 5380720 IODO VITAMIN D3COMPOUNDS AND METHOD FOR PREPARING SAME DeLuca Hector F; Sicinski Rafal R Deerfield, WI, UNITED STATES Assigned to Wisconsin Alumni Research Foundation Biologically active 1 alpha-hydroxy-22-iodinated vitamin D3 compounds and a process for the preparation of 1 alpha-hydroxy-22-iodinated vitamin D3 compounds are disclosed. The 22iodo-vitamin D3 compounds show relatively high binding affinity for the vitamin D receptor demonstrating their potential fo¢ high in vivo biological activity. Further, these compounds induce relatively high differentiation of malignant cells. Also, these 22-iodo compounds show high
NUCLEIC ACID ENCODING SODIUM CHANNEL PROTEIN Rogart Richard Chicago, IL, UNITED STATES Assigned to Arch Development Corporation The present invention relates generally to sodium channel proteins and more particularly to mammalian cardiac sodium channel proteins, to DNA sequences encoding sodium channel proteins, to the polypeptide products of recombinant expression of these DNA sequences, to pepfides whose sequences are based on amino acid sequences deduced from these DNA sequences, to antibodies specific for such proteins and peptides, and to procedures for detection and quantitation of such proteins and nucleic acids related thereto, as well as to procedures relating to the development of anti-an'hythmic and cardiotonic drugs.
PATENT ABSTRACTS
rim portion (56) for holding the bottles (16), with each the grasping clamps (60) being paired with another on the opposing wheel (43) such that a bottle (16) may be supported by both wheels (43). The perimeter surface (58) of each wheel is beveled to facilitate agitation. The drive shaft (40) is caused to rotate by a drive motor (36) and a drive linkage (38) which cause the rotisserie assembly (14) to rotate about a rotational axis (41), thus transporting and agitating the samples within the oven cavity (28). The incubator (10) is primarily utilized for nucleotide hybridization procedures.
in vivo calcium transport activity with little or no bone calcium mobifization activity. These compounds thus show promise in the treatment of osteoporosis.
5380833 POLYNUCLEOTIDE REAGENTS CONTAINING SELECTABLE CLEAVAGE SITES Urdea Michael S Alamo, CA, UNITED STATES Assigned to Chiton Corporation
5380712 TRUNCATED HUMAN SERUM ALBUMIN POLYPEPTIDES AS PLASMA EXPANDING AGENTS Ballance David J; Hinchliffe Edward; Geisow
Michael J; Senior Peter Attenborough, UNITED KINGDOM Assigned to Delta Biotechnology Limited Polypeptides corresponding to mature human serum albumin residues 1 to n, where n is between 369 and 419 inclusive, are useful as substitutes for albumin in the treatment of burns and shock in humans, the clearance of undesirable compounds, (such as bilirubin) from human blood, in laboratory growth media and in HSA assays. The polypep*ides may be produced by recombinant DNA techniques, especially in yeast.
Novel methods for assaying a nucleic acid analyte are provided, which employ polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest in the analyte, where the presence or absence of hybddiza*ion at a predetermined stringency provides for the release of a label from a support. Particularly, various techniques are employed for binding a label to a support, whereupon cleavage of either a single or double strand, a label may be released from a support,where the release of the label can be detected as indicative of the presence of a particular oligonucleotide sequence in a sample. The method finds use in diagnosis of disease, genetic monitoring, and analysis of nucleic acid mixtures.
5380836 5380720 IODO VITAMIN D3COMPOUNDS AND METHOD FOR PREPARING SAME DeLuca Hector F; Sicinski Rafal R Deerfield, WI, UNITED STATES Assigned to Wisconsin Alumni Research Foundation Biologically active 1 alpha-hydroxy-22-iodinated vitamin D3 compounds and a process for the preparation of 1 alpha-hydroxy-22-iodinated vitamin D3 compounds are disclosed. The 22iodo-vitamin D3 compounds show relatively high binding affinity for the vitamin D receptor demonstrating their potential fo¢ high in vivo biological activity. Further, these compounds induce relatively high differentiation of malignant cells. Also, these 22-iodo compounds show high
NUCLEIC ACID ENCODING SODIUM CHANNEL PROTEIN Rogart Richard Chicago, IL, UNITED STATES Assigned to Arch Development Corporation The present invention relates generally to sodium channel proteins and more particularly to mammalian cardiac sodium channel proteins, to DNA sequences encoding sodium channel proteins, to the polypeptide products of recombinant expression of these DNA sequences, to pepfides whose sequences are based on amino acid sequences deduced from these DNA sequences, to antibodies specific for such proteins and peptides, and to procedures for detection and quantitation of such proteins and nucleic acids related thereto, as well as to procedures relating to the development of anti-an'hythmic and cardiotonic drugs.