- Email: [email protected]
5393739 Use of bone morphogenetic protein in synergistic combination with TGF-Beta for bone repair
Cell Transplantatmn, Vol. 5. No I. III-VI, 1996 Copyright 0 1996 Elsewer Science Inc. Printed m the USA. All rights reserved 0890.263.6897/96 $15.00 + 00
ELSEVIER
PatentsALERT This section contains abstracts of recently issued United States patents and published patent applications filed from over 30 countries under the Patent Cooperation Treaty and compiled in accordance with interest profiles developed by the Editors.
5387234
hormone secreting cells, the islet chamber having baffle means inside thereof to assist in even distribution of the islets in the chamber, one or more vascularizing chambers open to surrounding tissue, a semi-permeable membrane between the islet and vascularizing chambers that allows passage of small molecules including insulin, oxygen and glucose and does not allow passage of agents of the immune system such as white cells and antibodies, the vascularizing chambers containing a growth factor soaked fibrous or foam matrix having a porosity of about 40 to 95%, the matrix providing small capillary growth and preventing the blood from clotting in the lower chamber.
VASCULAR PROSTHESIS, MANUFACTURING METHOD OF THE SAME, AND SUBSTRATE FOR VASCULAR PROSTHESIS Yasuhara; Miyata Teruo Assigned to Koken Co Ltd
Noishiki
Tottori, JAPAN
The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.
5393739 USE OF BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF- BETA FOR BONE REPAIR Bentz Hanne; Thompson Andrea; Armstrong Ros; Rosen David Newark, CA, UNITED STATES Assigned to Cellrix Pharmaceuticals Inc Bone morphogenetic proteins -2 and -3 (BMPs -2 and -3) work in synergistic combination with TGFbetaz to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disclosed.
5387237 BIOARTIFICIAL
5397353
PANCREAS
IMPLANT TISSUE
Fournier Ronald L; Goldblatt Peter J; Homer James M; Sarver Jeffrey G Sylvania, OH, UNWED STATES Assigned to The University of Toledo
Oliver Roy; Grant Roy UNITED KINGDOM
Dundee DDl
4HN,
A collagenous tissue preparation suitable for homotransplantation or heterotransplantion. The preparation is a non-resorbable, non-antigenic collagenous material which retains the natural
An implantable bioartitlcial pancreas device having an islet chamber containing glucose responsive and insulin-secreting islets of Langerhans or similar III
ELSEVIER
PatentsALERT This section contains abstracts of recently issued United States patents and published patent applications filed from over 30 countries under the Patent Cooperation Treaty and compiled in accordance with interest profiles developed by the Editors.
5387234
hormone secreting cells, the islet chamber having baffle means inside thereof to assist in even distribution of the islets in the chamber, one or more vascularizing chambers open to surrounding tissue, a semi-permeable membrane between the islet and vascularizing chambers that allows passage of small molecules including insulin, oxygen and glucose and does not allow passage of agents of the immune system such as white cells and antibodies, the vascularizing chambers containing a growth factor soaked fibrous or foam matrix having a porosity of about 40 to 95%, the matrix providing small capillary growth and preventing the blood from clotting in the lower chamber.
VASCULAR PROSTHESIS, MANUFACTURING METHOD OF THE SAME, AND SUBSTRATE FOR VASCULAR PROSTHESIS Yasuhara; Miyata Teruo Assigned to Koken Co Ltd
Noishiki
Tottori, JAPAN
The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.
5393739 USE OF BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF- BETA FOR BONE REPAIR Bentz Hanne; Thompson Andrea; Armstrong Ros; Rosen David Newark, CA, UNITED STATES Assigned to Cellrix Pharmaceuticals Inc Bone morphogenetic proteins -2 and -3 (BMPs -2 and -3) work in synergistic combination with TGFbetaz to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disclosed.
5387237 BIOARTIFICIAL
5397353
PANCREAS
IMPLANT TISSUE
Fournier Ronald L; Goldblatt Peter J; Homer James M; Sarver Jeffrey G Sylvania, OH, UNWED STATES Assigned to The University of Toledo
Oliver Roy; Grant Roy UNITED KINGDOM
Dundee DDl
4HN,
A collagenous tissue preparation suitable for homotransplantation or heterotransplantion. The preparation is a non-resorbable, non-antigenic collagenous material which retains the natural
An implantable bioartitlcial pancreas device having an islet chamber containing glucose responsive and insulin-secreting islets of Langerhans or similar III