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5401628 Polypeptides derived from the human immunodeficiency virus endonuclease protein
PATENT ABSTRACTS
A fragment of the gene for the hemagglutinin neuraminidase (HN protein) of human parainfluenza Type 2 virus (PIV-2) and materials containing such fragment. The fragment is complementary to the gene RNA for the PIV-2 HN protein and contains the entire coding regions for the PIV-2 HN protein. The fragment is useful as a test agent or a therapeutic agent for PIV-2 infections.
595
5401631 UNIVERSAL EUBACTERIA NUCLEIC ACID PROBES AND ASSAY METHODS Lane David J; Shah Jyotsna; Buharin Amelia; Weisburg William G Milford, MA, UNITED STATES Assigned to Amoco Corporation
POLYPEPTIDES DERIVED FROM THE HUMAN IMMUNODEFICIENCY VIRUS ENDONUCLEASE PROTEIN
Nucleic acid probes capable of hybridizing to rRNA of eubacteria and not to rRNA of noneubacteria are described along with methods utilizing such probes for the detection of eubacteria in clinical and other samples. Preferred embodiments include probes capable of distinguishing between gram-positive and gramnegative bacteria.
Chiodi Francesca Stockholm, SWEDEN Assigned to Ortho Diagnostic Systems Inc
5401632
5401628
A polypeptide linked to a solid matrix useful as a solid support of a diagnostic kit is disclosed. The polypeptide has the formula: X-Glu-Thr-Gly-GlnGlu-Thr-Ala-Tyr-Pbe-B-Leu-Lys-Leu-Ala-GlyArg-Trp-Pro-VaI-Lys-Z, wherein B is lie or Leu, X is a chain of from 1 to 20 amino acid residues or an amino-terminal group and Z is a chain of from 1 to 20 amino acid residues or a carboxyterminal group. The polypeptide immunologically mimics HIV endonuclease.
5401630 SPECIES-SPECIFIC DNA-DNA HYBRIDIZATION PROBE PREPARED USING C H R O M O S O M E SIZE DNA Torok Tama; King .A Douglas; Rockhold David R; Royer Christin Albany, CA, UNITED STATES Assigned to The United States of America as represented by the Secretary of Agriculture A species-specific DNA-DNA hybridization probe prepared using an isolated whole chromosome of a lower eukaryote as template. The probe is useful for the detection of conspecificity in lower eukaryotes selected from the group consisting of yeast and molds.
TRIPLE HELIX PURIFICATION AND SEQUENCING Wang Renfeng; Smith Lloyd M; Tong Xinchun Dublin, CA, UNITED STATES Assigned to Wisconsin Alumni Research Foundation Disclosed herein are methods, kits, and equipment for purifying single stranded circular DNA and then using the DNA for DNA sequencing purposes. Templates are provided with an insert having a hybridization region. An elongated oligonucleotide has two regions that are complementary to the insert and the oligo is bound to a magnetic anchor. The oligo hybridizes to the insert on two sides to form a stable triple helix complex. The anchor can then be used to drag the template out of solution using a magnet. The system can purify sequencing templates, and if desired the triple helix complex can be opened up to a double helix so that the oligonucleotide will act as a primer for further DNA synthesis.
5401634 STABLE BIOLOGICALLY ACTIVE FLUOROCHEMICAL EMULSIONS Milbrath Dean St Paul, MN, UNITED STATES Assigned to Minnesota Mining and Manufacturing Company
A fragment of the gene for the hemagglutinin neuraminidase (HN protein) of human parainfluenza Type 2 virus (PIV-2) and materials containing such fragment. The fragment is complementary to the gene RNA for the PIV-2 HN protein and contains the entire coding regions for the PIV-2 HN protein. The fragment is useful as a test agent or a therapeutic agent for PIV-2 infections.
595
5401631 UNIVERSAL EUBACTERIA NUCLEIC ACID PROBES AND ASSAY METHODS Lane David J; Shah Jyotsna; Buharin Amelia; Weisburg William G Milford, MA, UNITED STATES Assigned to Amoco Corporation
POLYPEPTIDES DERIVED FROM THE HUMAN IMMUNODEFICIENCY VIRUS ENDONUCLEASE PROTEIN
Nucleic acid probes capable of hybridizing to rRNA of eubacteria and not to rRNA of noneubacteria are described along with methods utilizing such probes for the detection of eubacteria in clinical and other samples. Preferred embodiments include probes capable of distinguishing between gram-positive and gramnegative bacteria.
Chiodi Francesca Stockholm, SWEDEN Assigned to Ortho Diagnostic Systems Inc
5401632
5401628
A polypeptide linked to a solid matrix useful as a solid support of a diagnostic kit is disclosed. The polypeptide has the formula: X-Glu-Thr-Gly-GlnGlu-Thr-Ala-Tyr-Pbe-B-Leu-Lys-Leu-Ala-GlyArg-Trp-Pro-VaI-Lys-Z, wherein B is lie or Leu, X is a chain of from 1 to 20 amino acid residues or an amino-terminal group and Z is a chain of from 1 to 20 amino acid residues or a carboxyterminal group. The polypeptide immunologically mimics HIV endonuclease.
5401630 SPECIES-SPECIFIC DNA-DNA HYBRIDIZATION PROBE PREPARED USING C H R O M O S O M E SIZE DNA Torok Tama; King .A Douglas; Rockhold David R; Royer Christin Albany, CA, UNITED STATES Assigned to The United States of America as represented by the Secretary of Agriculture A species-specific DNA-DNA hybridization probe prepared using an isolated whole chromosome of a lower eukaryote as template. The probe is useful for the detection of conspecificity in lower eukaryotes selected from the group consisting of yeast and molds.
TRIPLE HELIX PURIFICATION AND SEQUENCING Wang Renfeng; Smith Lloyd M; Tong Xinchun Dublin, CA, UNITED STATES Assigned to Wisconsin Alumni Research Foundation Disclosed herein are methods, kits, and equipment for purifying single stranded circular DNA and then using the DNA for DNA sequencing purposes. Templates are provided with an insert having a hybridization region. An elongated oligonucleotide has two regions that are complementary to the insert and the oligo is bound to a magnetic anchor. The oligo hybridizes to the insert on two sides to form a stable triple helix complex. The anchor can then be used to drag the template out of solution using a magnet. The system can purify sequencing templates, and if desired the triple helix complex can be opened up to a double helix so that the oligonucleotide will act as a primer for further DNA synthesis.
5401634 STABLE BIOLOGICALLY ACTIVE FLUOROCHEMICAL EMULSIONS Milbrath Dean St Paul, MN, UNITED STATES Assigned to Minnesota Mining and Manufacturing Company