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5403750 Biocompatible, low protein adsorption affinity matrix
PATENT ABSTRACTS
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5403750
5403862
BIOCOMPATIBLE, LOW PROTEIN ADSORPTION AFFINITY MATRIX
METHOD FOR ORAL DECORPORATION OF METALS
Braatz James A; Heifetz Aaron H Beltsville, MD, UNITED STATES Assigned to W R Grace & Co -Conn Affinity matrices useful for the chromatography and immobilization of biological materials and the method of preparing and using the same are disclosed. The affinity supports are based on hydrated polyurethane polymers which have been activated to provide a means for covalently attaching a variety of bioaffinity agents. The hydrated polymer matrices are characterized by their biocompatibility and resistance to nonspecific protein adsorption. Preferably, the prepolymers used to prepare the hydrated polymers are isocyanate-capped oxyethylenebased diols or polyols, at least 75% of said diols and polyols having a molecular weight of 7000 to about 30,000.
5403856 METHOD OF TREATING CARDIAC INSUFFICIENCY USING ANGIOTENSINCONVERTING ENZYME INHIBITORS Henning Raine; Urbach Hansjorg; Teetz Volker; Geiger Rolf; Scholkens Bemward Hattersheim am Main, GERMANY Assigned to Hoechst Aktiengeseilschaft The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I (*See Patent for Chemical Structure*) (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each denote hydrogen or an organic radical and R4 R5, together with the atoms carrying them, form a mono-, bi- or tricyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
Miller Scott C; Bruenger Friedrich Salt Lake City, UT, UNITED STATES Assigned to University of Utah Research Foundation Several new powerful chelating agents, suitable for the removal of a variety of certain heavy metal ions from the body by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyaminocarboxylic acids (PACA). They were synthesized in non-aqueous media from triethylenetetramine (TT) by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino groups using ethylbromoacetate and subsequent alkaline hydrolysis of the ester. Gel permeation chromatography of a mixture of the PACA and actinide elements have shown these substances to be strong chelating agents similar to EDTA or DTPA. In contrast to their non-lipophilic counterparts EDTA and DTPA, compositions of the present inventions exhibit appreciable absorption from the intestine and, therefore, can be administered orally. By varying the length of the alkyi chain, the chelons can be directed primarily to selected target organs. In addition, the compounds can be modified to target particular absorbed metals.
5403915 ISOLATION AND PURIFICATION OF LUNG SURFACTANT PROTEIN Benson Bradley; Buckley Douglas; Lesikar David; Naidu Asha; Silvemess Kate B San Francisco, CA, UNITED STATES Assigned to Scios Nova lnc Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C1-C4 aliphatic alcohol and chromatographic purification steps which employ a Cl-C4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
203
5403750
5403862
BIOCOMPATIBLE, LOW PROTEIN ADSORPTION AFFINITY MATRIX
METHOD FOR ORAL DECORPORATION OF METALS
Braatz James A; Heifetz Aaron H Beltsville, MD, UNITED STATES Assigned to W R Grace & Co -Conn Affinity matrices useful for the chromatography and immobilization of biological materials and the method of preparing and using the same are disclosed. The affinity supports are based on hydrated polyurethane polymers which have been activated to provide a means for covalently attaching a variety of bioaffinity agents. The hydrated polymer matrices are characterized by their biocompatibility and resistance to nonspecific protein adsorption. Preferably, the prepolymers used to prepare the hydrated polymers are isocyanate-capped oxyethylenebased diols or polyols, at least 75% of said diols and polyols having a molecular weight of 7000 to about 30,000.
5403856 METHOD OF TREATING CARDIAC INSUFFICIENCY USING ANGIOTENSINCONVERTING ENZYME INHIBITORS Henning Raine; Urbach Hansjorg; Teetz Volker; Geiger Rolf; Scholkens Bemward Hattersheim am Main, GERMANY Assigned to Hoechst Aktiengeseilschaft The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I (*See Patent for Chemical Structure*) (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each denote hydrogen or an organic radical and R4 R5, together with the atoms carrying them, form a mono-, bi- or tricyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
Miller Scott C; Bruenger Friedrich Salt Lake City, UT, UNITED STATES Assigned to University of Utah Research Foundation Several new powerful chelating agents, suitable for the removal of a variety of certain heavy metal ions from the body by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyaminocarboxylic acids (PACA). They were synthesized in non-aqueous media from triethylenetetramine (TT) by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino groups using ethylbromoacetate and subsequent alkaline hydrolysis of the ester. Gel permeation chromatography of a mixture of the PACA and actinide elements have shown these substances to be strong chelating agents similar to EDTA or DTPA. In contrast to their non-lipophilic counterparts EDTA and DTPA, compositions of the present inventions exhibit appreciable absorption from the intestine and, therefore, can be administered orally. By varying the length of the alkyi chain, the chelons can be directed primarily to selected target organs. In addition, the compounds can be modified to target particular absorbed metals.
5403915 ISOLATION AND PURIFICATION OF LUNG SURFACTANT PROTEIN Benson Bradley; Buckley Douglas; Lesikar David; Naidu Asha; Silvemess Kate B San Francisco, CA, UNITED STATES Assigned to Scios Nova lnc Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C1-C4 aliphatic alcohol and chromatographic purification steps which employ a Cl-C4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.