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5422251 Triple-stranded nucleic acids
302
PATENT ABSTRACTS
compounds that can be produced according to the invention have valuable pharmacological properties.
5422259
5422251 TRIPLE-STRANDED ACIDS
(e.g, baker's yeast) that is a traditional and safe foodstuff.
NUCLEIC
Fresco Jacques R Princeton, NJ, UNITED STATES Assigned to Princeton University A triple-stranded nucleic acid having a first nucleic acid strand that has a region of adjacent purine nucleoside residues; a second nucleic acid strand, at least a portion of which is hydrogen bonded in a Watson-Crick manner to the region of adjacent purine nucleoside residues of the first strand; and a third nucleic acid strand, at least a portion of which is hydrogen bonded to the portion of the region of adjacent purine nucleoside residues of the first strand, the portion of the region of adjacent purine nucleoside residues to which both the second strand and the third strand are bonded defining the triple-stranded nucleic acid.
TRANSGENIC PLANTS BELONGING TO THE SPECIES CUCUMIS MELO De Both Michiel; Ben Tahar Sophia; Noel Marianne; Perret Joel Beaumont, FRANCE Assigned to Biosem Procedure for the production of transgenic seedlings starting from genetically transformed buds, the said seedlings belonging to the species Cucumus melo and containing at least one gene introduced through the intermediary of Agrobacterium tumefaciens, characterized by the culture in two successive stages of genetically transformed buds, the first of these steps taking place in a plant cell culture medium containing a cytokinin and more particularly 6-benzyl aminopurine (BAP), and the second, which is performed when the buds have attained a height of about at least 3 mm, taking place in a plant cell culture medium containing as macro-elements: (*See Patent for Tabular Presentation*) PS
5422254 METHOD TO INCREASE THE TREHALOSE CONTENT OF ORGANISMS BY TRANSFORMING THEM WITH THE STRUCTURAL GENES FOR THE SHORT AND LONG CHAINS OF YEAST TREHALOSE SYNTHASE Londesborough John; Vuorio O u t i FINLAND Assigned to Oy Alko Ab
Helsinki,
Two nucleotide sequences encoding two different polypeptides found in yeast trehalose synthase have been isolated and cloned. The coding sequences can be inserted into suitable vectors and used to transform host cells. The transformed cells will produce increased amounts of trehalose compared to the untransformed wild types and have increased tolerance to a variety of stresses, in particular to decreased availability of water. The invention may be used to improve the stress tolerance of organisms, to increase the storage life of foodstuffs and to produce trehalose economically on an industrial scale in an organism
5422262 STEROID 5A REDUCTASE NUCLEIC ACID SEGMENTS AND RECOMBINANT VECTORS AND HOST CELLS Andersson Sefan; Russell David New York, NY, UNITED STATES Assigned to Board of Regents The University of Texas System Disclosed are methods and compositions for the preparation of steroid 5 alpha-reductases by recombinant means, as well as for the use of these enzymes in screening assays for the identification of compounds which have the ability to inhibit or otherwise alter the enzymatic function of these enzymes. Biochemical and pharmacological evidence is presented to demonstrate the existence of more than one human steroid 5 alpha-reductase. The DNA sequence encoding steroid 5 alphareductase 2, the major active isozyme of human genital tissue, is disclosed herein, in addition to methods and compositions for its preparation and pharmacological analysis. The sequences disclosed herein may be used directly in the
PATENT ABSTRACTS
compounds that can be produced according to the invention have valuable pharmacological properties.
5422259
5422251 TRIPLE-STRANDED ACIDS
(e.g, baker's yeast) that is a traditional and safe foodstuff.
NUCLEIC
Fresco Jacques R Princeton, NJ, UNITED STATES Assigned to Princeton University A triple-stranded nucleic acid having a first nucleic acid strand that has a region of adjacent purine nucleoside residues; a second nucleic acid strand, at least a portion of which is hydrogen bonded in a Watson-Crick manner to the region of adjacent purine nucleoside residues of the first strand; and a third nucleic acid strand, at least a portion of which is hydrogen bonded to the portion of the region of adjacent purine nucleoside residues of the first strand, the portion of the region of adjacent purine nucleoside residues to which both the second strand and the third strand are bonded defining the triple-stranded nucleic acid.
TRANSGENIC PLANTS BELONGING TO THE SPECIES CUCUMIS MELO De Both Michiel; Ben Tahar Sophia; Noel Marianne; Perret Joel Beaumont, FRANCE Assigned to Biosem Procedure for the production of transgenic seedlings starting from genetically transformed buds, the said seedlings belonging to the species Cucumus melo and containing at least one gene introduced through the intermediary of Agrobacterium tumefaciens, characterized by the culture in two successive stages of genetically transformed buds, the first of these steps taking place in a plant cell culture medium containing a cytokinin and more particularly 6-benzyl aminopurine (BAP), and the second, which is performed when the buds have attained a height of about at least 3 mm, taking place in a plant cell culture medium containing as macro-elements: (*See Patent for Tabular Presentation*) PS
5422254 METHOD TO INCREASE THE TREHALOSE CONTENT OF ORGANISMS BY TRANSFORMING THEM WITH THE STRUCTURAL GENES FOR THE SHORT AND LONG CHAINS OF YEAST TREHALOSE SYNTHASE Londesborough John; Vuorio O u t i FINLAND Assigned to Oy Alko Ab
Helsinki,
Two nucleotide sequences encoding two different polypeptides found in yeast trehalose synthase have been isolated and cloned. The coding sequences can be inserted into suitable vectors and used to transform host cells. The transformed cells will produce increased amounts of trehalose compared to the untransformed wild types and have increased tolerance to a variety of stresses, in particular to decreased availability of water. The invention may be used to improve the stress tolerance of organisms, to increase the storage life of foodstuffs and to produce trehalose economically on an industrial scale in an organism
5422262 STEROID 5A REDUCTASE NUCLEIC ACID SEGMENTS AND RECOMBINANT VECTORS AND HOST CELLS Andersson Sefan; Russell David New York, NY, UNITED STATES Assigned to Board of Regents The University of Texas System Disclosed are methods and compositions for the preparation of steroid 5 alpha-reductases by recombinant means, as well as for the use of these enzymes in screening assays for the identification of compounds which have the ability to inhibit or otherwise alter the enzymatic function of these enzymes. Biochemical and pharmacological evidence is presented to demonstrate the existence of more than one human steroid 5 alpha-reductase. The DNA sequence encoding steroid 5 alphareductase 2, the major active isozyme of human genital tissue, is disclosed herein, in addition to methods and compositions for its preparation and pharmacological analysis. The sequences disclosed herein may be used directly in the