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5427937 Hookworm anticoagulant
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PATENT ABSTRACTS
5427917 METHOD OF DETERMINING HUMAN ACID GLUTATHIONE STRANSFERASE, REAGENT, THEREFOR, KIT THEREFOR, METHOD OF DIAGNOSING CANCER IN DIGESTIVE ORGANS, AND MONOCLONAL ANTIBODY FOR USE THEREIN Hosoda Kenji; Honda Hitomi;Kubota Takaharu; Suzuki Hideaki Saitama, JAPAN Assigned to Teijin Limited A method of immunologically determining human acid glutathione S-transferase in a human assay sample, which comprises bringing the assay sample into contact with a first antibody bound to an insoluble solid career and a labelled second antibody, either the first or second antibody being a polyclonal antibody capable of recognizing human acid glutathione S-transferase or an equivalent fragment of the polyclonal antibody, and the other antibody being a monoclonal antibody capable of specifically recognizing human acid glutathione S-transferase or an equivalent fragment of the monoclonal antibody, a method of diagnosing cancer in a human digestive organ by using the above method, a reagent therefor, a kit therefor and a monoclonal antibody for use therein.
polyacrylamide gel electrophoresis with PN-2 isolated from human fibroblast cultures. Other characteristics of the antibody are that the antibody specifically binds to PN-2 and to the secreted form of betaAPP lacking the Kunitz-type inhibitor domain, the antibody selectively binds to neuritic plaques, and the antibody is sufficiently sensitive to detect secreted forms of betaAPP in CSF, down to a total concentration of the secreted forms of betaAPP of 3.75 mug/ml or lower.
5427937 HOOKWORM ANTICOAGULANT Cappello Michael; Hotez Peter J; Richards Frank F; Hawdon John M New Haven, CT, 06511, UNITED STATES A soluble anticoagulant protein isolated and purified from Ancylostoma hookworms markedly prolongs both the prothrombin time and partial thromboplastin time in clotting assays. The protein has an apparent molecular weight of about 6500 daltons and exhibits amino acid sequence homology to the Kunitz-type serine protease inhibitor family. Chromogenic peptide substrate and clotting time assays indicate that the protein inhibits extrinsic pathway clotting factor VIIa, the enzyme responsible for initiating the human coagulation cascade, and factor Xa in the common pathway of the coagulation cascade.
5427931 MONOCLONAL ANTIBODY PRODUCED AGAINST NATIVE BETAAMYLOID PRECURSOR PROTEIN Van Nostrand William E; Cunningham Dennis D; Wagner Steven Irvine, CA, UNITED STATES Assigned to The Regents of the University of California Monoclonal antibody and the hybridoma producing the antibody are disclosed. The antibody is produced against an epitope on native secreted forms of betaAPP. A characteristic of the antibody is that the antibody specifically binds to at least one protein in culture medium in which neuroblastoma cells have been grown. This protein co-migrates in non-reducing
5427941 ACTINOMADURA BRUNNEA VAR. ANTIBIOTICA STRAINS Smith Elizabeth; Munayyer Hanan; Ryan Michael J; Miller George Plainsboro, NJ, UNITED STATES Assigned to Schering Corporation 7-Chloro-8-methoxytetracycline isolated from antibiotic ES-I19 and antibiotic Tet. 7 which are produced by fermentation of mutants of Actinomadura brunnea, namely Actinomadura brunnea var. antibiotica, ATCC 53108 and Actinomadura brunnea var antibiotica ATCC 53180 and its use as an antibiotic against grampositive and gram-negative organisms are disclosed.
PATENT ABSTRACTS
5427917 METHOD OF DETERMINING HUMAN ACID GLUTATHIONE STRANSFERASE, REAGENT, THEREFOR, KIT THEREFOR, METHOD OF DIAGNOSING CANCER IN DIGESTIVE ORGANS, AND MONOCLONAL ANTIBODY FOR USE THEREIN Hosoda Kenji; Honda Hitomi;Kubota Takaharu; Suzuki Hideaki Saitama, JAPAN Assigned to Teijin Limited A method of immunologically determining human acid glutathione S-transferase in a human assay sample, which comprises bringing the assay sample into contact with a first antibody bound to an insoluble solid career and a labelled second antibody, either the first or second antibody being a polyclonal antibody capable of recognizing human acid glutathione S-transferase or an equivalent fragment of the polyclonal antibody, and the other antibody being a monoclonal antibody capable of specifically recognizing human acid glutathione S-transferase or an equivalent fragment of the monoclonal antibody, a method of diagnosing cancer in a human digestive organ by using the above method, a reagent therefor, a kit therefor and a monoclonal antibody for use therein.
polyacrylamide gel electrophoresis with PN-2 isolated from human fibroblast cultures. Other characteristics of the antibody are that the antibody specifically binds to PN-2 and to the secreted form of betaAPP lacking the Kunitz-type inhibitor domain, the antibody selectively binds to neuritic plaques, and the antibody is sufficiently sensitive to detect secreted forms of betaAPP in CSF, down to a total concentration of the secreted forms of betaAPP of 3.75 mug/ml or lower.
5427937 HOOKWORM ANTICOAGULANT Cappello Michael; Hotez Peter J; Richards Frank F; Hawdon John M New Haven, CT, 06511, UNITED STATES A soluble anticoagulant protein isolated and purified from Ancylostoma hookworms markedly prolongs both the prothrombin time and partial thromboplastin time in clotting assays. The protein has an apparent molecular weight of about 6500 daltons and exhibits amino acid sequence homology to the Kunitz-type serine protease inhibitor family. Chromogenic peptide substrate and clotting time assays indicate that the protein inhibits extrinsic pathway clotting factor VIIa, the enzyme responsible for initiating the human coagulation cascade, and factor Xa in the common pathway of the coagulation cascade.
5427931 MONOCLONAL ANTIBODY PRODUCED AGAINST NATIVE BETAAMYLOID PRECURSOR PROTEIN Van Nostrand William E; Cunningham Dennis D; Wagner Steven Irvine, CA, UNITED STATES Assigned to The Regents of the University of California Monoclonal antibody and the hybridoma producing the antibody are disclosed. The antibody is produced against an epitope on native secreted forms of betaAPP. A characteristic of the antibody is that the antibody specifically binds to at least one protein in culture medium in which neuroblastoma cells have been grown. This protein co-migrates in non-reducing
5427941 ACTINOMADURA BRUNNEA VAR. ANTIBIOTICA STRAINS Smith Elizabeth; Munayyer Hanan; Ryan Michael J; Miller George Plainsboro, NJ, UNITED STATES Assigned to Schering Corporation 7-Chloro-8-methoxytetracycline isolated from antibiotic ES-I19 and antibiotic Tet. 7 which are produced by fermentation of mutants of Actinomadura brunnea, namely Actinomadura brunnea var. antibiotica, ATCC 53108 and Actinomadura brunnea var antibiotica ATCC 53180 and its use as an antibiotic against grampositive and gram-negative organisms are disclosed.