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5443957 Anti-asialo-GM1 monoclonal antibodies and method of use
586
PATENT ABSTRACTS
baculovirus, infecting insect cells or insect host with the resulting recombinant virus, culturing it and purifying the obtained chimeric protein. The gag chimeric protein of H1V according to the present invention retains both antigenic and immunogenic properties.
of the antibody fragment or intact antibody, and target the diagnostic or therapeutic principle to a target tissue where the diagnostic or therapeutic effect is realized. Thus, the invention contemplates the use of such immunoconjugates for diagnosis and immunotherapy. The invention further relates to methods for preparing such immunoconjugates.
5443831 GENEENCODING GLYCOPROTEINBOF INFECTIOUS LARYNGOTRACHEITISVIRUS Keeler Calvin; Poulsen David Newark, DE, UNITED STATES assigned to University of Delaware An isolated nucleic acid molecule encoding the gB glycoprotein of Infectious Laryngotracheitis Virus is disclosed. Also disclosed is incorporation of the gB gene into recombinant avipox virus for a vaccine used to immunize fowl.
5443957 ANTI-ASIALO-GM1 MONOCLONAL ANTIBODIES AND METHOD OF USE Shimada Shizi; Sudo Tadashi; Iwata Daiji Chiba, JAPAN assigned to Mitsui Toatsu Chemicals Inc A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal immunized with the glycolipid asialo GM1 with myeloma cells.
5443953 5443965
PREPARATION AND USE OF IMMUNOCONJUGATES HEPATITIS Hansen Hans J; Leung Shui-on; Shevitz Jerry Mystic Island, NJ, UNITED STATES assigned to lmmunomedics Inc The present invention relates to immunoconjugates comprising an antibody fragment which is covalentiy bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an antibody moiety that is an intact antibody containing a glycosylation site in the light chain variable domain which has been introduced into the antibody by mutating the nucleotide sequence encoding the light chain. The resultant immunoconjugates retain the immunoreactivity
C VIRUS EPITOPES
Reyes Gregory; Kim Jungsuh P; Moeckli Randolph Palo Alto, CA, UNITED STATES assigned to Genelabs Incorporated Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.
PATENT ABSTRACTS
baculovirus, infecting insect cells or insect host with the resulting recombinant virus, culturing it and purifying the obtained chimeric protein. The gag chimeric protein of H1V according to the present invention retains both antigenic and immunogenic properties.
of the antibody fragment or intact antibody, and target the diagnostic or therapeutic principle to a target tissue where the diagnostic or therapeutic effect is realized. Thus, the invention contemplates the use of such immunoconjugates for diagnosis and immunotherapy. The invention further relates to methods for preparing such immunoconjugates.
5443831 GENEENCODING GLYCOPROTEINBOF INFECTIOUS LARYNGOTRACHEITISVIRUS Keeler Calvin; Poulsen David Newark, DE, UNITED STATES assigned to University of Delaware An isolated nucleic acid molecule encoding the gB glycoprotein of Infectious Laryngotracheitis Virus is disclosed. Also disclosed is incorporation of the gB gene into recombinant avipox virus for a vaccine used to immunize fowl.
5443957 ANTI-ASIALO-GM1 MONOCLONAL ANTIBODIES AND METHOD OF USE Shimada Shizi; Sudo Tadashi; Iwata Daiji Chiba, JAPAN assigned to Mitsui Toatsu Chemicals Inc A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal immunized with the glycolipid asialo GM1 with myeloma cells.
5443953 5443965
PREPARATION AND USE OF IMMUNOCONJUGATES HEPATITIS Hansen Hans J; Leung Shui-on; Shevitz Jerry Mystic Island, NJ, UNITED STATES assigned to lmmunomedics Inc The present invention relates to immunoconjugates comprising an antibody fragment which is covalentiy bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an antibody moiety that is an intact antibody containing a glycosylation site in the light chain variable domain which has been introduced into the antibody by mutating the nucleotide sequence encoding the light chain. The resultant immunoconjugates retain the immunoreactivity
C VIRUS EPITOPES
Reyes Gregory; Kim Jungsuh P; Moeckli Randolph Palo Alto, CA, UNITED STATES assigned to Genelabs Incorporated Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.