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5472853 Enzymatic process for cephalosporins
PATENT ABSTRACTS
proteins alpha&Q and/or alpha2-M in the field of the determination and assay of plasminogen activators and inhibitors of said plasminogen activators. It relates in particular to a method of determining (i) a plasminogen activator selected from the group consisting of tissue plasminogen (tPAs) and urokinase activators plasminogen activators (uPAs), and (ii) an inhibitor (PAI) of said plasminogen activator, said method, which involves converting plasminogen to plasmin and then assaying the plasmin resulting from said conversion, comprising inhibition of the plasma proteins alpha%antiplasmin and/or alpha2macroglobulin by means of a substance selected from the group consisting of metalloproteinase materials.
129
5472853 ENZYMATIC PROCESS CEPHALOSPORINS
FOR
Baldwin Jack Headington, UNITED KINGDOM assigned to University of Oxford N-Terminal beta, gamma-didehydrovaline di- and tri-peptides are reacted with isopenicillin N synthetase to form 3-exomethylenecepham-4-carboxylic acids, e.g., delta-(L- alpha-aminoadipoyl)L-cysteinyl-Dbeta, gammadidehydrovaline is incubated with the purified enzyme to provide 7 beta-(Lalpha-aminoadipoylamino)-3-exomethyle acid. necepham-4-carboxylic The 3-exocepham products are useful intermediates to 3-alkoxy-3-cephem and the 3-halo-3-cephem antibiotics.
5472852
ASSAY FOR DETECTION OF SELECTIVE PROTEIN C INHIBITION BY PATIENTS Smimov Mikhail D; Esmon Charles Oklahoma City, OK, UNITED STATES assigned to Oklahoma Medical Research Foundation An assay useful for detecting the propensity of patients for thrombotic disease, especially patients having the lupus anticoagulant or antiphospholipid antibodies, is described. The assay is conducted on patient and control plasma in the presence and absence of exogenous Protein C with a membrane source comprising phosphatidylethanolamine and phosphatidylserine. Patients at risk exhibit test results indicating activated Protein C function is inhibited.
5472854 PROCESS FOR THE PRODUCTION OF 17-OXOSTEROIDS VIA THE FERMENTATIVE OXIDATION OF 17 BETAHYDROXYSTEROIDS BY MYCOBACTERIUM Weber Alfred; Kennekke Mari; Klages Uwe; Nickisch Klau; Rohde Ralph Berlin, GERMANY assigned to Schering Aktiengesellschafi A process for the production of 17-oxosteroids by fermentative oxidation of 17 beta-hydroxy steroids is described, which is characterized in that for the fermentation, a bacterial culture of the species Mycobacterium spec. NRRL
proteins alpha&Q and/or alpha2-M in the field of the determination and assay of plasminogen activators and inhibitors of said plasminogen activators. It relates in particular to a method of determining (i) a plasminogen activator selected from the group consisting of tissue plasminogen (tPAs) and urokinase activators plasminogen activators (uPAs), and (ii) an inhibitor (PAI) of said plasminogen activator, said method, which involves converting plasminogen to plasmin and then assaying the plasmin resulting from said conversion, comprising inhibition of the plasma proteins alpha%antiplasmin and/or alpha2macroglobulin by means of a substance selected from the group consisting of metalloproteinase materials.
129
5472853 ENZYMATIC PROCESS CEPHALOSPORINS
FOR
Baldwin Jack Headington, UNITED KINGDOM assigned to University of Oxford N-Terminal beta, gamma-didehydrovaline di- and tri-peptides are reacted with isopenicillin N synthetase to form 3-exomethylenecepham-4-carboxylic acids, e.g., delta-(L- alpha-aminoadipoyl)L-cysteinyl-Dbeta, gammadidehydrovaline is incubated with the purified enzyme to provide 7 beta-(Lalpha-aminoadipoylamino)-3-exomethyle acid. necepham-4-carboxylic The 3-exocepham products are useful intermediates to 3-alkoxy-3-cephem and the 3-halo-3-cephem antibiotics.
5472852
ASSAY FOR DETECTION OF SELECTIVE PROTEIN C INHIBITION BY PATIENTS Smimov Mikhail D; Esmon Charles Oklahoma City, OK, UNITED STATES assigned to Oklahoma Medical Research Foundation An assay useful for detecting the propensity of patients for thrombotic disease, especially patients having the lupus anticoagulant or antiphospholipid antibodies, is described. The assay is conducted on patient and control plasma in the presence and absence of exogenous Protein C with a membrane source comprising phosphatidylethanolamine and phosphatidylserine. Patients at risk exhibit test results indicating activated Protein C function is inhibited.
5472854 PROCESS FOR THE PRODUCTION OF 17-OXOSTEROIDS VIA THE FERMENTATIVE OXIDATION OF 17 BETAHYDROXYSTEROIDS BY MYCOBACTERIUM Weber Alfred; Kennekke Mari; Klages Uwe; Nickisch Klau; Rohde Ralph Berlin, GERMANY assigned to Schering Aktiengesellschafi A process for the production of 17-oxosteroids by fermentative oxidation of 17 beta-hydroxy steroids is described, which is characterized in that for the fermentation, a bacterial culture of the species Mycobacterium spec. NRRL