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5475101 DNA sequence encoding endoglucanase III cellulase
PATENT ABSTRACTS
95
5475101
5476768
DNA SEQUENCE ENCODING ENDOGLUCANASE HI CELLULASE
MYCOBACTERIOPHAGE DSGA SPECIFIC FOR THE MYCOBACTERIUM TUBERCULOSIS
Ward Michael; Clarkson Kathleen A; Larenas Edmund A; Larch Jeffrey D; Weiss Geoffrey L Half Moon Bay, CA, UNITED STATES assigned to Genencor International Inc The present invention is directed to purified EG III cellulase enzyme isolated from Trichoderma longibrachiatum and the amino acid sequence of the secreted (mature) and non-secreted (preprotein) forms. The present invention is further directed to the DNA fragment and sequence that encodes the EG III cellulase enzyme. Also disclosed are methods for isolating either purified or highly enriched EG III cellulase obtained from Trichoderma spp. or genetically modified strains of Trichoderma spp.
5476766 LIGANDS
COMPLEX
Pearson Robert E; Dickson Hamilton Paul T; Little Michael Wayne F Durham, NC, UNITED assigned to Becton Dickinson and
Julie A; C; Beyer STATES Company
Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage LS and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase beta subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.
OF THROMBIN
Boulder, CO, Gold Larry; Tasset Diane UNITED STATES assigned to Nexstar Pharmaceuticals Inc Methods are described for the identification of nuclei acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for Exponential enrichment) method for identifying and preparing RNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the RNA ligands identified. The modified RNA ligands to thrombin exhibit increased in vivo stability.
5476774 QUANTITATION OF NUCLEIC ACIDS USING THE POLYMERASE CHAIN REACTION Wang Alice M; Doyle Michael V; Mark David F Walnut Creek, CA, UNITED STATES assigned to Hoffmann-La Roche Inc
95
5475101
5476768
DNA SEQUENCE ENCODING ENDOGLUCANASE HI CELLULASE
MYCOBACTERIOPHAGE DSGA SPECIFIC FOR THE MYCOBACTERIUM TUBERCULOSIS
Ward Michael; Clarkson Kathleen A; Larenas Edmund A; Larch Jeffrey D; Weiss Geoffrey L Half Moon Bay, CA, UNITED STATES assigned to Genencor International Inc The present invention is directed to purified EG III cellulase enzyme isolated from Trichoderma longibrachiatum and the amino acid sequence of the secreted (mature) and non-secreted (preprotein) forms. The present invention is further directed to the DNA fragment and sequence that encodes the EG III cellulase enzyme. Also disclosed are methods for isolating either purified or highly enriched EG III cellulase obtained from Trichoderma spp. or genetically modified strains of Trichoderma spp.
5476766 LIGANDS
COMPLEX
Pearson Robert E; Dickson Hamilton Paul T; Little Michael Wayne F Durham, NC, UNITED assigned to Becton Dickinson and
Julie A; C; Beyer STATES Company
Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage LS and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase beta subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.
OF THROMBIN
Boulder, CO, Gold Larry; Tasset Diane UNITED STATES assigned to Nexstar Pharmaceuticals Inc Methods are described for the identification of nuclei acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for Exponential enrichment) method for identifying and preparing RNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the RNA ligands identified. The modified RNA ligands to thrombin exhibit increased in vivo stability.
5476774 QUANTITATION OF NUCLEIC ACIDS USING THE POLYMERASE CHAIN REACTION Wang Alice M; Doyle Michael V; Mark David F Walnut Creek, CA, UNITED STATES assigned to Hoffmann-La Roche Inc