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5550022 Method for the determination of pathogenic Listeria bacteria
PatentsALERT
5550017 ANTI-PARAMYXOVIRUS SCREENING M E T H O D AND VACCINE Compans Richard W Atlanta, GA, UNITED STATES assigned to Emory University A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of inhibiting paramyxovirus-induced cell fusion. The methods are based on the discovery that the hemagglutination and fusion-inducing proteins of paramyxoviruses interact to form a complex termed HN:F, that is prerequisite to cell fusion. Antibodies to HN:F provide a novel means of providing improved immunity against paramyxovirus infection.
5550022 M E T H O D FOR THE D E T E R M I N A T I O N OF P A T H O G E N I C LISTERIA BACTERIA Chakraborty Trinad; Goebel Werner; Notermans Servatius H W Wurzburg, GERMANY assigned to Boehringer Mannheim GmbH Nucleic acids which preferably hybridize under the hybridization conditions 5-6* SSC and 42°C to 60°C with a 2.5 kb large KpnI-BamHI fragment from pLM63, preferably with a nucleic acid. Such nucleic acids are suitable for hybridization tests for Listeria bacteria if they contain reporter groups. Proteins are also described which are suitable for the production of antibodies
VII
against Listeria bacteria.
5552141 POLYMERIC IMMUNOLOGICAL ADJUVANTS Ribi Hans O STATES
San Mateo, CA, UNITED
Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.
5552146 METHODS AND COMPOSITIONS RELATING TO USEFUL ANTIGENS OF M O R A X E L L A CATARRHALIS Hansen Eric J; Helminen Merja; Maciver Isobel Piano, TX, UNITED STATES assigned to Board of Regents The University of Texas System The present disclosure relates to selected antigenic proteins obtained from the outer membranes of Moraxella catarrhalis, that have been found by the inventors to have a variety of useful properties. These proteins, termed OMPs (Outer Membrane Proteins), are
5550017 ANTI-PARAMYXOVIRUS SCREENING M E T H O D AND VACCINE Compans Richard W Atlanta, GA, UNITED STATES assigned to Emory University A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of inhibiting paramyxovirus-induced cell fusion. The methods are based on the discovery that the hemagglutination and fusion-inducing proteins of paramyxoviruses interact to form a complex termed HN:F, that is prerequisite to cell fusion. Antibodies to HN:F provide a novel means of providing improved immunity against paramyxovirus infection.
5550022 M E T H O D FOR THE D E T E R M I N A T I O N OF P A T H O G E N I C LISTERIA BACTERIA Chakraborty Trinad; Goebel Werner; Notermans Servatius H W Wurzburg, GERMANY assigned to Boehringer Mannheim GmbH Nucleic acids which preferably hybridize under the hybridization conditions 5-6* SSC and 42°C to 60°C with a 2.5 kb large KpnI-BamHI fragment from pLM63, preferably with a nucleic acid. Such nucleic acids are suitable for hybridization tests for Listeria bacteria if they contain reporter groups. Proteins are also described which are suitable for the production of antibodies
VII
against Listeria bacteria.
5552141 POLYMERIC IMMUNOLOGICAL ADJUVANTS Ribi Hans O STATES
San Mateo, CA, UNITED
Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.
5552146 METHODS AND COMPOSITIONS RELATING TO USEFUL ANTIGENS OF M O R A X E L L A CATARRHALIS Hansen Eric J; Helminen Merja; Maciver Isobel Piano, TX, UNITED STATES assigned to Board of Regents The University of Texas System The present disclosure relates to selected antigenic proteins obtained from the outer membranes of Moraxella catarrhalis, that have been found by the inventors to have a variety of useful properties. These proteins, termed OMPs (Outer Membrane Proteins), are