- Email: [email protected]
5605840 Method for the detection of gastric epithelial damage
748
PATENT ABSTRACTS
generally has a gel phase, i.e., the biocompatible matrix and cells, and a liquid phase containing a concentrated solution of the cell product to be harvested. Thus, the bioreactor of this invention uses only two chambers to achieve three distinct zones within the apparatus. A bioartificial liver is based on a bioreactor of the type having two fluid paths separated by a permeable medium. The bioreactor can be of either hollow fiber or fiat-bed configuration. In the configuration using hollow fibers, the two fluid paths correspond to the cavity surrounding the hollow fibers (the extracapillary space), and to the lumens of the hollow fibers themselves. Both fluid paths have inlet and outlet ports. Communication between the two fluid paths is across the permeable medium-the hollow fiber material. Hepatocytes are inoculated into the hollow fibers in a solution which quickly forms a highly porous gel. The gel subsequently contracts, leaving an open channel within the hollow fiber adjacent to the gel core entrapped hepatocytes. This channel can be perfused with nutrient media for hepatocytes. The channel can also serve as a waste stream to remove toxins that the hepatocytes have modified to a water soluble form.
5605836 MODULAR DEVICE
METHOD FOR
AND
THE
EVALUATION OF THE ABILITY OF BIOCIDE TO PENETRATE BIOFILM Chen Chin-Yu; Swei Woan-Jiun Chung Ho City, CHINA (TAIWAN) A thickness modular device for use in the evaluation of the ability of a biocide to penetrate biofilms of varying thicknesses is disclosed. It comprises: (a) a petri dish including a horizontal base and a continuous sidewall mending vertically from the base; (b) a dish cover including a flat base with a top and underside for closing the dish; (c) an internal thickness module having a fiat top and bottom surface and being positioned adjacent the horizontal base for producing depressions on a surface of a biofilm; and (d) a locking member for connecting in a locking relation the dish cover with the internal thickness module.
5605840 METHOD
FOR
THE
DETECTION OF GASTRIC EPITHELIAL DAMAGE Meddings Jonathan; Sutherland Lloy; Wallace John L Calgary, CANADA Disclosed is a method for the detection of gastric epithelial damage and a method which is performed by administering a disaccharide to a patient,assaying the patient's blood or urine for the presence of the disaccharide and correlating the determined disaccharide assay value to gastric epithelial damage.
5606025 HEMOGLOBIN-ENZYME COMPLEXES D'Agnillo Felice; Chang Thomas M S Montreal, Quebec, CANADA Crosslinked hemoglobin preparations having chemically bound thereto superoxide dismutase (SOD) and catalase are provided, for use as oxygen carrying rescusitative fluids, e.g. blood substitutes. The enzymes crossllnked to the hemoglobin effectively scavenge super oxide and hydrogen peroxide to improve the performance of the fluid in respect of ischemia-reperfusion injury risks.
5606027 ANTIBODIES TO A NEUTROPHIL CHEMOTACTIC PROTEIN Elgebaly Salwa A STATES
Bloomfield, CT, UNITED
Antibodies to a neutrophil chemotactic protein (NOURIN-I) specific to that protein are provided. The antibodies can be used in diagnostic assays and as pharmaceutical agents. The chemotactic protein represents the initial signal that recruits neutrophils to injured tissue and exhibits a molecular weight of approximately 3 KDa and an isoelectric point of pH 7-8.
PATENT ABSTRACTS
generally has a gel phase, i.e., the biocompatible matrix and cells, and a liquid phase containing a concentrated solution of the cell product to be harvested. Thus, the bioreactor of this invention uses only two chambers to achieve three distinct zones within the apparatus. A bioartificial liver is based on a bioreactor of the type having two fluid paths separated by a permeable medium. The bioreactor can be of either hollow fiber or fiat-bed configuration. In the configuration using hollow fibers, the two fluid paths correspond to the cavity surrounding the hollow fibers (the extracapillary space), and to the lumens of the hollow fibers themselves. Both fluid paths have inlet and outlet ports. Communication between the two fluid paths is across the permeable medium-the hollow fiber material. Hepatocytes are inoculated into the hollow fibers in a solution which quickly forms a highly porous gel. The gel subsequently contracts, leaving an open channel within the hollow fiber adjacent to the gel core entrapped hepatocytes. This channel can be perfused with nutrient media for hepatocytes. The channel can also serve as a waste stream to remove toxins that the hepatocytes have modified to a water soluble form.
5605836 MODULAR DEVICE
METHOD FOR
AND
THE
EVALUATION OF THE ABILITY OF BIOCIDE TO PENETRATE BIOFILM Chen Chin-Yu; Swei Woan-Jiun Chung Ho City, CHINA (TAIWAN) A thickness modular device for use in the evaluation of the ability of a biocide to penetrate biofilms of varying thicknesses is disclosed. It comprises: (a) a petri dish including a horizontal base and a continuous sidewall mending vertically from the base; (b) a dish cover including a flat base with a top and underside for closing the dish; (c) an internal thickness module having a fiat top and bottom surface and being positioned adjacent the horizontal base for producing depressions on a surface of a biofilm; and (d) a locking member for connecting in a locking relation the dish cover with the internal thickness module.
5605840 METHOD
FOR
THE
DETECTION OF GASTRIC EPITHELIAL DAMAGE Meddings Jonathan; Sutherland Lloy; Wallace John L Calgary, CANADA Disclosed is a method for the detection of gastric epithelial damage and a method which is performed by administering a disaccharide to a patient,assaying the patient's blood or urine for the presence of the disaccharide and correlating the determined disaccharide assay value to gastric epithelial damage.
5606025 HEMOGLOBIN-ENZYME COMPLEXES D'Agnillo Felice; Chang Thomas M S Montreal, Quebec, CANADA Crosslinked hemoglobin preparations having chemically bound thereto superoxide dismutase (SOD) and catalase are provided, for use as oxygen carrying rescusitative fluids, e.g. blood substitutes. The enzymes crossllnked to the hemoglobin effectively scavenge super oxide and hydrogen peroxide to improve the performance of the fluid in respect of ischemia-reperfusion injury risks.
5606027 ANTIBODIES TO A NEUTROPHIL CHEMOTACTIC PROTEIN Elgebaly Salwa A STATES
Bloomfield, CT, UNITED
Antibodies to a neutrophil chemotactic protein (NOURIN-I) specific to that protein are provided. The antibodies can be used in diagnostic assays and as pharmaceutical agents. The chemotactic protein represents the initial signal that recruits neutrophils to injured tissue and exhibits a molecular weight of approximately 3 KDa and an isoelectric point of pH 7-8.