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609 Renoprotective effects of aliskiren following ischemia reperfusion injury
609
Renoprotective effects of aliskiren following ischemia reperfusion injury Eur Urol Suppl 2013;12;e609
Hammad F.1, Al-Salam S.2, Lubbad L.1 1
College of Medicine & Health Sciences, Dept. of Surgery, Al Ain, United Arab Emirates, 2College of Medicine &
Health Sciences, Dept. of Pathology, Al Ain, United Arab Emirates INTRODUCTION & OBJECTIVES: Renin-angiotensin system blockade by angiotensin converting enzyme inhibitors or angiotensin receptor blockers has been shown to ameliorate the renal dysfunction following ischemia-reperfusion injury (IRI), but the effect of blocking the first and rate-limiting step in this cascade by aliskiren, the first approved direct oral renin inhibitor, has not been investigated yet. Thus, the aim of this study was to investigate the effect of aliskiren on the alterations in renal functional parameters following warm ischemia-reperfusion injury. MATERIAL & METHODS: Wistar rats underwent left renal ischemia for 40 minutes. Group-1 received normal saline and served as a control group whereas Group-2 received aliskiren (30 mg/kg/day) by gavage for 6 days commencing one day before IRI. The hemodynamic and tubular renal function of the right and left kidneys were measured using clearance technique five days following the IRI RESULTS: The mean arterial blood pressure and heart rate in both groups were similar. In Group-1, the left RBF, five days following IRI, was 17% of the right renal blood flow (RBF) (0.39±0.05 vs. 2.24±0.27, PNa) in the left kidney was significantly higher than the right kidney (49.7±7.8 vs. 2.9±0.4, P<0.0001). When Group-1 and Group-2 were compared, the left RBF was significantly higher in Group-2 (1.28±0.36 vs. 0.39±0.05, P=0.007). Left kidney GFR was also higher in Group-2 but did not reach statistical significance (0.18±0.05 vs. 0.10±0.02, P=0.07). On the other hand, the left renal FENa was significantly lower in Group-2 (29.9±6.4 vs. 49.7±7.8, P=0.03). CONCLUSIONS: The administration of aliskiren before during and after IRI appears to have ameliorated the IRI effect on the hemodynamic and tubular renal the renal functional parameters indicating a renoprotective effect of this oral renin inhibitor on the renal functions in IRI.
Renoprotective effects of aliskiren following ischemia reperfusion injury Eur Urol Suppl 2013;12;e609
Hammad F.1, Al-Salam S.2, Lubbad L.1 1
College of Medicine & Health Sciences, Dept. of Surgery, Al Ain, United Arab Emirates, 2College of Medicine &
Health Sciences, Dept. of Pathology, Al Ain, United Arab Emirates INTRODUCTION & OBJECTIVES: Renin-angiotensin system blockade by angiotensin converting enzyme inhibitors or angiotensin receptor blockers has been shown to ameliorate the renal dysfunction following ischemia-reperfusion injury (IRI), but the effect of blocking the first and rate-limiting step in this cascade by aliskiren, the first approved direct oral renin inhibitor, has not been investigated yet. Thus, the aim of this study was to investigate the effect of aliskiren on the alterations in renal functional parameters following warm ischemia-reperfusion injury. MATERIAL & METHODS: Wistar rats underwent left renal ischemia for 40 minutes. Group-1 received normal saline and served as a control group whereas Group-2 received aliskiren (30 mg/kg/day) by gavage for 6 days commencing one day before IRI. The hemodynamic and tubular renal function of the right and left kidneys were measured using clearance technique five days following the IRI RESULTS: The mean arterial blood pressure and heart rate in both groups were similar. In Group-1, the left RBF, five days following IRI, was 17% of the right renal blood flow (RBF) (0.39±0.05 vs. 2.24±0.27, PNa) in the left kidney was significantly higher than the right kidney (49.7±7.8 vs. 2.9±0.4, P<0.0001). When Group-1 and Group-2 were compared, the left RBF was significantly higher in Group-2 (1.28±0.36 vs. 0.39±0.05, P=0.007). Left kidney GFR was also higher in Group-2 but did not reach statistical significance (0.18±0.05 vs. 0.10±0.02, P=0.07). On the other hand, the left renal FENa was significantly lower in Group-2 (29.9±6.4 vs. 49.7±7.8, P=0.03). CONCLUSIONS: The administration of aliskiren before during and after IRI appears to have ameliorated the IRI effect on the hemodynamic and tubular renal the renal functional parameters indicating a renoprotective effect of this oral renin inhibitor on the renal functions in IRI.