612 INFLUENCE OF NON-GENETIC FACTORS ON INCIDENCE OF FAMILIAL PROSTATE CANCER. NATION-WIDE POPULATION-BASED STUDY IN PCBASE SWEDEN

FRUHื  RU &DUWHU HW DO F7 ELRSV\ *OHDVRQ ื 36$ GHQVLW\ื SRVLWLYH FRUHืRIFDQFHULQDQ\FRUH ZHUHVHOHFWHG7KLVUHVXOWHGLQ  DQG    SDWLHQWV UHVSHFWLYHO\ 3DWLHQWV ZHUH GLYLGHG LQ DJH FDWHJRULHV DFFRUGLQJWRWHUWLOHVQDPHO\ืDQG!\UV :HHYDOXDWHGWKHQXPEHU RI SDWLHQWV VXLWDEOH IRU $6 DV ZHOO DV WKH UDWHV RI XQIDYRXUDEOH SURVWDWH FDQFHU FKDUDFWHULVWLFVDWSDWKRORJ\GHᚏQHGDV*OHDVRQVFRUHุSUHVHQFHRIQRQRUJDQ FRQᚏQHG GLVHDVH  DFFRUGLQJ WR HDFK DJH FDWHJRU\ 3HDUVRQಬV FRUUHODWLRQV ZHUH XVHGWRWHVWWKHGLᚎHUHQFHVEHWZHHQWKHDJHFDWHJRULHVIRUHDFKDQDO\VLV$8& DQDO\VLVWHVWHGWKHDFFXUDF\RIWKHFULWHULDDFFRUGLQJWRDJH Results: 0HDQ DQG PHGLDQ DJH ZDV  DQG  \HDUV UHVSHFWLYHO\ 0HDQ DQGPHGLDQQXPEHURIELRSV\FRUHVWDNHQZDVDQGUHVSHFWLYHO\$W53 Q  RISDWLHQWVVXLWDEOHIRU$6DFFRUGLQJWR9DQGHQ%HUJKHWDOFULWHULD KDG SDWKRORJLFDOO\ GHᚏQHG DGYHUVH SURVWDWH FDQFHU ,QWHUHVWLQJO\ WKH UDWH RI XQIDYRXUDEOHSURVWDWHFDQFHUVLJQLᚏFDQWO\LQFUHDVHGZLWKSDWLHQWDJHEHLQJ DQGLQSDWLHQWVDJHGืDQG!\UVUHVSHFWLYHO\S   7KHDFFXUDF\RIWKHWHVWHGFULWHULDLQSUHGLFWLQJDGYHUVHSDWKRORJ\GHFUHDVHGIURP WRLQ\RXQJHUื\UV YVROGHU!\UV SDWLHQWV6LPLODUUHVXOWVZHUH DFKLHYHG ZKHQ WKH FULWHULD SURSRVHG E\ &DUWHU HW DO ZHUH XVHG 2YHUDOO  Q   RI SDWLHQWV KDG DGYHUVH SDWKRORJLFDO RXWFRPH DW 53 ZKLFK VLJQLᚏFDQWO\ LQFUHDVHGZLWKDJHืDQG!\UVS  7KH DFFXUDF\RIWKHFULWHULDSURSRVHGE\&DUWHUHWDOUDQJHGEHWZHHQLQ\RXQJHU ื\UV YVLQROGHUSDWLHQWV!\UV  Conclusions: 5RXJKO\RISDWLHQWVWUHDWHGZLWK53PD\EHVHOHFWHGIRU$6 SURWRFROVDFFRUGLQJWRWKHFULWHULDSURSRVHGE\9DQGHQ%HUJKHWDODQG&DUWHUHWDO :HGHPRQVWUDWHGWKDWWKHSHUIRUPDQFHRIVXFKUHFRPPHQGDWLRQVGHFUHDVHZLWK LQFUHDVLQJSDWLHQWDJH7KXVFDUHVKRXOGEHWDNHQZKHQDSSO\LQJWKHVHFULWHULDLQ ROGHUSDWLHQWVZKRDUHJHQHUDOO\FRQVLGHUHGPRUHVXLWDEOHIRU$6SURWRFROV

610

ADENOCARCINOMA OF THE PROSTATE: IS ENDORECTAL MRI AT 1,5 TESLA HELPFUL TO SELECT CANDIDATES FOR ACTIVE SURVEILLANCE?

/X\FN[)+DOORXLQ3&KDXYHDX3%DUU«&$LOOHW*%RXFKRW2 5LJDXG- 1 CHU Hotel Dieu, Dept. of Urology, Nantes, France, 2Clinique Jules Verne, Dept. of Radiology, Nantes, France, 3Clinique Jules Verne, Dept. of Urology, Nantes, France, 4Institut d’Histopathologie (IHP), Dept. of Pathology, Nantes, France Introduction & Objectives: $ VLJQLᚏFDQW SURSRUWLRQ RI SDWLHQWV TXLW DFWLYH VXUYHLOODQFH DIWHU WKH VHFRQG URXQG RI SURVWDWH ELRSVLHV :H WU\ WR DVVHVV WKH XVHIXOQHVVRIHQGRUHFWDO05LQUHᚏQLQJWKHVHOHFWLRQRISDWLHQWVIRUZKRPDFWLYH VXUYHLOODQFHFRXOGEHSURSRVHG Material & Methods: :HUHWURVSHFWLYHO\UHYLHZHGSDWLHQWVSUHVHQWLQJDOOWKH FULWHULDWRFKRRVHDFWLYHVXUYHLOODQFHDVGHVFULEHGLQWKH6XU$F$3SURWRFRO)UDQFH  LQDVHULHVRISDWLHQWVZKRDOOKDGUDGLFDOSURVWDWHFWRP\DQGHQGRUHFWDO05 DWWHVOD3HOYLF3KDVHG$UUD\7HU05,33$ EHIRUHVXUJHU\7KHDELOLW\RI 05 LQ SUHGLFWLQJ WXPRXU YROXPH !  FF LH ಯQRQODWHQW SURVWDWH FDQFHUರ  ZDV DVVHVVHGE\XVLQJWKHIROORZLQJFULWHULRQ$QXPEHURISRVLWLYHVH[WDQWV136  E\ DGGLQJ SRVLWLYH VH[WDQWV DW ELRSV\ DQGRU 05 VWULFWO\ RYHU  ಯ136!ರ  05 ᚏQGLQJVZHUHFRUUHODWHGWRWKHSDWKRORJLFDOᚏQGLQJV Results: $WSDWKRORJ\ SDWLHQWVKDGQRQRUJDQFRQᚏQHGWXPRXUIRFDO S7D DQG  HVWDEOLVKHG S7D  QR RQH ZDV VXVSHFWHG E\ 05 7KHUH ZHUH   ELODWHUDODGHQRFDUFLQRPDV7XPRXUYROXPH79 ZDVLQIHULRUWRFFLQ    SDWLHQWV ,QDSSDUHQW WXPRXU DW 05 FRQFHUQHG    SDWLHQWV 7KHYDOXHRIWKHVLJQಯ136!ರDVDSUHGLFWRURIWXPRXUYROXPH!FFLVSUHVHQWHG LQWDEOH 136! 6HQVLWLYLW\ 6SHFLᚏFLW\ 3RVLWLYH3UHGLFWLYH9DOXH 1HJDWLYH3UHGLFWLYH9DOXH

7XPRXUYROXPH!FF    

7DEOH  9DOXH RI WKH VLJQ ಯ136!ರ LQ GHWHFWLQJ WXPRXU JUHDWHU WKDQ  FF  SDWLHQWV Conclusions: ,QRXUVHULHVRQO\RISDWLHQWVZKRFRXOGKDYHFKRVHQDFWLYH VXUYHLOODQFHDFFRUGLQJWR6XU$F$3SURWRFROKDGWXPRXUYROXPHFF(QGRUHFWDO 05 FDQ EH XVHIXO LQ VHOHFWLQJ SDWLHQWV IRU SURSRVLQJ DFWLYH VXUYHLOODQFH :KHQ DGGLQJSRVLWLYHVH[WDQWVDW7HU05,33$DQGRUDWELRSV\LIWKHVXPLVVWULFWO\ !LWFRXOGDOORZWKHXURORJLVWWRGHWHFWRIQRQODWHQWSURVWDWHFDQFHU

611

RULE-BASED VERSUS PROBABILISTIC SELECTION FOR ACTIVE SURVEILLANCE FOR PROSTATE CANCER AND OUTCOMES AFTER RADICAL PROSTATECTOMY

9DQ'HQ%HUJK5&16WH\HUEHUJ(:9DQ/HHXZHQ3-:ROWHUV7 $XV*5RRERO0-%DQJPD&++XJRVVRQ-6FKU¸GHU)+ 1 Erasmus Univeristy Medical Centre, Dept. of Urology and Public Health, Rotterdam, The Netherlands, 2Erasmus Univeristy Medical Centre, Dept. of Public Health, Rotterdam, The Netherlands, 3Erasmus Univeristy Medical Centre, Dept. of Urology, Rotterdam, The Netherlands, 4Sahlgrenska Univeristy Hospital, Dept. of Urology, Gothenburg, Sweden

Eur Urol Suppl 2010;9(2):204

Introduction & Objectives: 7KH FXUUHQWO\ DSSOLHG LQFOXVLRQ FULWHULD IRU DFWLYH VXUYHLOODQFH$6 IRUSURVWDWHFDQFHU3& PD\VHOHFWPHQZKRDFWXDOO\KDUERXU QRQLQGROHQWKLVWRSDWKRORJLFDOGLVHDVH:HH[SORUHGWKHHᚎHFWRIUXOHEDVHGFULWHULD IRU$6DVZHOODVWKHDOWHUQDWLYHRIXVLQJSUREDELOLVWLFVHOHFWLRQXVLQJDQRPRJUDP DQGRIIXUWKHUWLJKWHQLQJWKHWKUHVKROGVE\VWXG\LQJWKHIUHTXHQF\RILQGROHQW3& DWUDGLFDOSURVWDWHFWRP\53  Material & Methods: 6ZHGLVKDQG'XWFKSDWLHQWVSDUWLFLSDWLQJLQWKH(XURSHDQ 5DQGRPL]HG 6WXG\ RI 6FUHHQLQJ IRU 3URVWDWH &DQFHU (563&  ZKR ZHUH GLDJQRVHG ZLWK3&DQG ZKR SULPDULO\ UHFHLYHG 53ZHUH VWXGLHG 7KHIUHTXHQF\ RILQGROHQWGLVHDVHDW53WXPRXUYROXPHPOFRQᚏQHGWRWKHSURVWDWHZLWK QR*OHDVRQSDWWHUQRU DQGELRFKHPLFDOSURJUHVVLRQ36$!QJPO GXULQJ IROORZXS ZHUH DVVHVVHG 7KH SHUIRUPDQFH UHJDUGLQJ WKHVH WZR RXWFRPHV ZDV DVVHVVHGRIUXOHEDVHGVHOHFWLRQFULWHULDIRU$6FOLQLFDOVWDJH7F736$e QJPO36$GHQVLW\QJPOFF*OHDVRQVFRUHeQRSDWWHUQRU RU SRVLWLYHELRSV\FRUHVFULWHULDXVHGLQWKHSURVSHFWLYH35,$6VWXG\ ZLWKDGGLWLRQDO VWULFWHU WKUHVKROGV DQG RI WKH DSSOLFDWLRQ RI D QRPRJUDP IRU SUHGLFWLQJ LQGROHQW GLVHDVHFULWHULDIRUHOLJLELOLW\FOLQLFDOVWDJH7F7D36$ QJPO*OHDVRQ VFRUH  QRSDWWHUQRU  SRVLWLYHFRUHV PP3&! PP EHQLJQWLVVXHLQDOOFRUHV ZLWKLQFUHDVLQJULVNWKUHVKROGV Results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ᚏQHPHQWVLQVHOHFWLRQGLGQRWUHVXOWLQVLJQLᚏFDQWLPSURYHPHQWV RIWKH\HDUUDWHVRIELRFKHPLFDOSURJUHVVLRQDIWHU53RI7KHSHUIRUPDQFH RIUXOHEDVHGYHUVXVSUREDELOLW\EDVHGVHOHFWLRQVWUDWHJLHVZDVODUJHO\VLPLODU Conclusions: (YHQZKHQLQFOXGLQJRQO\DVPDOOJURXSRIPHQIRU$6ZLWKWKHPRVW VWULQJHQWFULWHULDWKHUHLVDWUDGHRᚎRILQFOXGLQJVRPHPHQZLWKKLVWRSDWKRORJLFDOO\ VLJQLᚏFDQW 3& :LWK DQ DGHTXDWH $6 SURWRFRO WKDW GHWHFWV LQLWLDO XQGHUVDPSOLQJ RU GLVHDVH SURJUHVVLRQ WLPHO\ WKH DGYHUVH HᚎHFWV RQ PRUELGLW\ DQG PRUWDOLW\ RI DQLQLWLDOPLVFODVVLᚏFDWLRQPD\KRZHYHUEHOLPLWHG3UREDELOLVWLFVHOHFWLRQIRU$6 LV SRVVLEOH ZLWK D QRPRJUDP WKDW LQFRUSRUDWHV YDULRXV SURJQRVWLF IDFWRUV LQWR D SUHGLFWLRQPRGHODQGPD\EHSUHIHUDEOH

612

INFLUENCE OF NON-GENETIC FACTORS ON INCIDENCE OF FAMILIAL PROSTATE CANCER. NATION-WIDE POPULATION-BASED STUDY IN PCBASE SWEDEN

6WDWWLQ3(*DUPR+$GROIVVRQ-%LOO$[HOVRQ$+ROPEHUJ//DPEH0 %UDWW2 1 Umeå University, Dept. of Surgical and Perioperative Science, Urology and Andrology, Umeå, Sweden, 2Uppsala University Hospital, Regional Oncological Centre, Uppsala, Sweden, 3Karolinska Institute, Oncological Centre, Clintec, Stockholm, Sweden, 4Uppsala University Hospital, Dept. of Urology, Uppsala, Sweden, 5Kings College London, Medical School, Division of Cancer Studies, London, United Kingdom, 6Karolinska Institute, Dept. of Medical Epidemiology and Biostatistics, Stockholm, Sweden, 7Helsingborg Hospital, Lund University, Dept. of Urology, Helsingborg, Sweden Introduction & Objectives: )DPLO\ KLVWRU\ LV D VWURQJ ULVN IDFWRU IRU SURVWDWH FDQFHU3&D DQGIDPLOLDODJJUHJDWLRQRI3&DLVFDXVHGE\JHQHWLFDQGQRQJHQHWLF IDFWRUV7KHDLPRIWKLVVWXG\ZDVWRLQYHVWLJDWHKRZQRQJHQHWLFIDFWRUVDᚎHFWULVN RI3&DDPRQJEURWKHUVRIPHQZLWK3&D Material & Methods: :H LGHQWLᚏHG  LQGH[ FDVHV ZLWK 3&D DQG  EURWKHUV WR WKHVH LQGH[ FDVHV LQ 3&%D6H 6ZHGHQ ZKLFK LQFOXGHV GDWD IURP WKH 1DWLRQDO 3URVWDWH &DQFHU 5HJLVWHU 13&5  RI 6ZHGHQ WKH 6ZHGLVK &DQFHU 5HJLVWHUWKH5HJLVWHURIWKH7RWDO3RSXODWLRQWKH0XOWL*HQHUDWLRQ5HJLVWHUDQG WKH &HQVXV GDWDEDVH :H DVVHVVHG WKH LQᚐXHQFH RI WXPRU FKDUDFWHULVWLFV WLPH IURPGLDJQRVLVRIWKHLQGH[FDVHDQGVRFLRHFRQRPLFVWDWXVRQWKHVWDQGDUGL]HG LQFLGHQFHUDWLRV6,5 RI3&DLQEURWKHUVWRWKHLQGH[FDVHVLQFRPSDULVRQZLWKDQ DJHPDWFKHGEDFNJURXQGSRSXODWLRQ Results: 6,5IRU3&DDPRQJPHQZLWKRQHEURWKHUGLDJQRVHGZLWK3&DZDV &,  DQG6,5ZDVKLJKHUIRU3&DLQVWDJH7F WKDQ IRUPHWDVWDWLF3&D 'XULQJWKHᚏUVW\HDUDIWHUGLDJQRVLVRIWKHLQGH[ FDVH 6,5 ZDV    YV 6,5V RI  GXULQJ WKH IROORZLQJ \HDUV 6,5 IRU 3&D ZDV KLJKHU DPRQJ PHQ ZLWK KLJKHU FRPSDUHG WR ORZHU VRFLRHFRQRPLF VWDWXV YV DQGLQSDUWLFXODUIRUVWDJH7F  YV )ROORZLQJDVHFRQGGLDJQRVLVRISURVWDWHFDQFHUDPRQJEURWKHUV LQDIDPLO\WKHULVNIRUWKHUHPDLQLQJEURWKHUVZDVIXUWKHULQFUHDVHG6,5IRU3&D LQVWDJH7FZDV DQGIRUPHWDVWDWLF3&D 6,5IRUVWDJH 7FWXPRXUVGXULQJWKHᚏUVW\HDUZDV DQG6,5EH\RQGRQH\HDUZDV  6,5ZDVIRU3&DLQVWDJH7FIRUPHQZLWKKLJKHUVRFLRHFRQRPLFVWDWXV ZDV DQGIRUPHQZLWKORZHUVRFLRHFRQRPLFVWDWXV  Conclusions: $ GLDJQRVLV RI 3&D LQ D EURWKHU WULJJHUV PHQ WR XQGHUJR 36$ WHVWLQJ LQ SDUWLFXODU DPRQJ PHQ ZLWK KLJKHU VRFLRHFRQRPLF VWDWXV GXULQJ WKH ᚏUVW\HDUDIWHUGLDJQRVLVRIWKHLQGH[FDVH7KHLQFUHDVHGGLDJQRVWLFDFWLYLW\OHDGV WRGHWHFWLRQELDVDQGFRQVHTXHQWO\ LQᚐDWHG6,5VDQGZLOOGHFUHDVHWKHJHQHWLF FRPSRQHQW DV D FDXVH RI IDPLOLDO DJJUHJDWLRQ RI 3&D 7KLV VWXG\ ZDV PDGH

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613

RESULTS FROM BRACHYTHERAPY FOR PATIENTS AGED 60 YEARS AND YOUNGER

+LQQHQ.$9DQ5RHUPXQG-*+%DWWHUPDQQ--9DQ9XOSHQ0 1 University Medical Center Utrecht, Dept. of Radiation Oncology, Utrecht, The Netherlands, 2University Medical Center Utrecht, Dept. of Urology, Utrecht, The Netherlands Introduction & Objectives: 7KH SRVLWLRQ RI SURVWDWH EUDFK\WKHUDS\ LQ WUHDWLQJ SDWLHQWV DJHG  \HDUV DQG \RXQJHU LV XQFOHDU PDLQO\ GXH WR D ODFN RI IROORZ XS SURYLQJ LWV ORQJWHUP HᚎHFWLYHQHVV 7KLV VWXG\ GHVFULEHV WKH UHVXOWV IRU EUDFK\WKHUDS\LQSDWLHQWVDJHG\HDUVDQG\RXQJHUFRPSDUHGWRSDWLHQWVDJHG RYHU\HDUV Material & Methods: $ WRWDO RI  SDWLHQWV WUHDWHG IURP  XS WR  ZHUH UHWURVSHFWLYHO\ DQDO\VHG 7UHDWPHQW FRQVLVWHG RI XOWUDVRXQG JXLGHG , PRQRWKHUDS\DWDWRWDOGRVHRI*UD\$OOSDWLHQWVKDG7VWDJHืF*OHDVRQ VFRUHืORFDOO\FRQᚏQHGSURVWDWHFDQFHUZLWKDPD[LPXPSURVWDWHYROXPHRIFF DWLPSODQWDWLRQ3DWLHQWVZLWKODUJHUJODQGYROXPHVUHFHLYHGPRQWKRIDQGURJHQ GHSULYDWLRQWKHUDS\IRUGRZQVL]LQJ(QGSRLQWVZHUHGLVHDVHVSHFLᚏFVXUYLYDO'66  DQGRYHUDOOVXUYLYDO26 0HDQIROORZXSZDVPRQWKVs6WDQGDUG'HYLDWLRQ  

Material & Methods:  PHQ ZLWK HDUO\ SURVWDWH FDQFHU ZHUH WUHDWHG ZLWK WUDQVSHULQHDO LQWHUVWLWLDO ORZ GRVH UDWH EUDFK\WKHUDS\ %7  XVLQJ WKH UHDO WLPH LQWUDRSHUDWLYH 3UR6HHG WHFKQLTXH EHWZHHQ 1RYHPEHU  DQG 2FWREHU  0HGLDQIROORZXSZDVPRQWKV 3DWLHQWVZHUHVWUDWLᚏ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ᚏQHGXVLQJWKH$6752 DQG$67523KRHQL[FRQVHQVXVGHᚏQLWLRQV Results: 7KHPHDQLQWUDRSHUDWLYH'WRWKHSURVWDWH&793 ZDV*\ *\ IDOOLQJWR*\*\ RQWKH3,'VFDQ7KHPHDQLQWUDRSHUDWLYH &7939ZDV IDOOLQJWR DW3,'7KHPHDQ9 IRUSURVWDWH&793 ZDV DQG DWLPSODQWDQGSRVW LPSODQWUHVSHFWLYHO\7KHPHDQ&7939ZDV DWLPSODQWULVLQJ WR SRVWLPSODQW7KHPHDQLQWUDRSHUDWLYHSURVWDWHPDUJLQ&7930  ' ZDV *\ *\  IDOOLQJ WR *\ *\  DW 3,'   SDWLHQWV  UHFHLYHG D 3,' ' ุ*\ WR WKH &793 7KH 36$ UHODSVH UDWH ZDV SDWLHQWV XVLQJERWKGHᚏQLWLRQV2QO\SDWLHQWUHFHLYHG*\WRWKHSRVW LPSODQW &793 QHLWKHU UHODSVHG ELRFKHPLFDOO\ 7KH UHFDWKHWHULVDWLRQ UDWH ZDV 7KHVWULFWXUHUDWHZDV Conclusions: )ROORZLQJWKLVVWXG\ZHZRXOGUHFRPPHQGDQLQWUDRSHUDWLYH' WR WKH &793 RI *\ %\ GRLQJ WKLV WKH LQWUDRSHUDWLYH SURVWDWH PDUJLQ &79 30 'RI*\ZDVDFKLHYHGZKLFKJDYHDSRVWLPSODQW'WRWKHSURVWDWH ุ*\ LQ  SDWLHQWV 7KH ORZ UHODSVH UDWH LQ WKLV JURXS DFNQRZOHGJHV WKH LPSRUWDQFHRIWKH*\'WRWKH3,'&793DVDTXDOLW\VWDQGDUG7KLVGRVH LVZHOOWROHUDWHG

615

WITHDRAWN

616

RE-IMPLANTATION AFTER INSUFFICIENT PRIMARY 125-I PERMANENT BRACHYTHERAPY OF PROSTATE CANCER

(QJHOHU'63XWRUD33ODVVZLOP/6HHOHQWDJ::6FKLHIHU+ 6FKPLG+3 1 Cantonal Hospital of St. Gallen, Dept. of Urology, St. Gallen, Switzerland, 2 Cantonal Hospital of St. Gallen, Dept. of Radio-Oncology, St. Gallen, Switzerland

Results: 3DWLHQWV DJHG ื   SDWLHQWV  KDG VPDOOHU WXPRXUV S    ZLWK ORZHULQLWLDO36$YDOXHVS FRPSDUHGWRSDWLHQWVDJHG!SDWLHQWV  7KH  \HDU '66 DQG 26 UDWHV  &RQᚏGHQFH ,QWHUYDOV  ZHUH    DQG IRUDJHืDQG DQG IRUDJH!7KH GLᚎHUHQFH LQ '66 UDWHV ZDV QRW VLJQLᚏFDQW 7R DGMXVW IRU SRWHQWLDO FRQIRXQGLQJ IDFWRUV DQG EDVHOLQH GLᚎHUHQFHV D PXOWLYDULDWH &R[5HJUHVVLRQ DQDO\VLV ZDV SHUIRUPHG$JHVKRZHGDQRQVLJQLᚏFDQW+D]DUG5DWLR+5 RI&, S  6LJQLᚏFDQFHZDVUHDFKHGIRUWKHYDULDEOHV7VWDJH+5 &,S  ,QLWLDO36$+5&,S DQG *OHDVRQVFRUH+5&, )LJXUH.DSODQ0HLHUFXUYHRIDJH DQGGLVHDVHVSHFLᚏFVXUYLYDO Conclusions: 7KHUHVXOWV\HDUVDIWHUEUDFK\WKHUDS\DUHH[FHOOHQWIRUSDWLHQWV DJHG\HDUVDQG\RXQJHUDVZHOODVIRUSDWLHQWVDJHGRYHU\HDUV2QO\WKH WXPRXU FKDUDFWHULVWLFV SUHGLFWHG IRU SURVWDWH FDQFHU VXUYLYDO :LWK UHVSHFW WR FDQFHUFXUDELOLW\DJHDWSURVWDWHFDQFHUGLDJQRVLVGRHVQRWQHHGEHDUHVWULFWLRQ IRUWUHDWPHQWZLWKEUDFK\WKHUDS\

614

RECOMMENDATIONS FOR REAL TIME BRACHYTHERAPY PRESCRIPTIONS USING ESTRO/EAU/ EORTC 2007 VOLUME DEFINITIONS TO REDUCE THE CHANCE OF PSA FAILURE

'DOODV1/0DORQH35-RQHV$'RJJDUW$--RQHV-&5RJHUV3% 1 Royal Berkshire Hospital, Berkshire Cancer Centre, Reading, United Kingdom, 2 Royal Berkshire Hospital, Harold Hopkins Dept. of Urology, Reading, United Kingdom Introduction & Objectives: $PLQLPXPSRVWLPSODQW'RI*\WRWKHSURVWDWH &793 UHVXOWVLQVXSHULRUIUHHGRPIURPELRFKHPLFDOIDLOXUH7RGDWHWKHUHLVQR UHFRPPHQGHGUHDOWLPHLQWUDRSHUDWLYH'VSHFLᚏHGWRDFKLHYHWKLV:HDQDO\VHG WKHLQWUDRSHUDWLYHDQGSRVWLPSODQWGRVLPHWU\3,' XVLQJWKH(6752($8(257& UHFRPPHQGDWLRQVDQGUHSRUWRXUH[SHULHQFHRIWKH'999 WR WKH &793 DQG WKH ' WR WKH SURVWDWH PDUJLQ &7930  WR VHH ZKDW LQWUD RSHUDWLYH&793GRVHZRXOGDFKLHYH*\SRVWLPSODQW

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Eur Urol Suppl 2010;9(2):205