613 RESULTS FROM BRACHYTHERAPY FOR PATIENTS AGED 60 YEARS AND YOUNGER

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613

RESULTS FROM BRACHYTHERAPY FOR PATIENTS AGED 60 YEARS AND YOUNGER

+LQQHQ.$9DQ5RHUPXQG-*+%DWWHUPDQQ--9DQ9XOSHQ0 1 University Medical Center Utrecht, Dept. of Radiation Oncology, Utrecht, The Netherlands, 2University Medical Center Utrecht, Dept. of Urology, Utrecht, The Netherlands Introduction & Objectives: 7KH SRVLWLRQ RI SURVWDWH EUDFK\WKHUDS\ LQ WUHDWLQJ SDWLHQWV DJHG  \HDUV DQG \RXQJHU LV XQFOHDU PDLQO\ GXH WR D ODFN RI IROORZ XS SURYLQJ LWV ORQJWHUP HᚎHFWLYHQHVV 7KLV VWXG\ GHVFULEHV WKH UHVXOWV IRU EUDFK\WKHUDS\LQSDWLHQWVDJHG\HDUVDQG\RXQJHUFRPSDUHGWRSDWLHQWVDJHG RYHU\HDUV Material & Methods: $ WRWDO RI  SDWLHQWV WUHDWHG IURP  XS WR  ZHUH UHWURVSHFWLYHO\ DQDO\VHG 7UHDWPHQW FRQVLVWHG RI XOWUDVRXQG JXLGHG , PRQRWKHUDS\DWDWRWDOGRVHRI*UD\$OOSDWLHQWVKDG7VWDJHืF*OHDVRQ VFRUHืORFDOO\FRQᚏQHGSURVWDWHFDQFHUZLWKDPD[LPXPSURVWDWHYROXPHRIFF DWLPSODQWDWLRQ3DWLHQWVZLWKODUJHUJODQGYROXPHVUHFHLYHGPRQWKRIDQGURJHQ GHSULYDWLRQWKHUDS\IRUGRZQVL]LQJ(QGSRLQWVZHUHGLVHDVHVSHFLᚏFVXUYLYDO'66  DQGRYHUDOOVXUYLYDO26 0HDQIROORZXSZDVPRQWKVs6WDQGDUG'HYLDWLRQ  

Material & Methods:  PHQ ZLWK HDUO\ SURVWDWH FDQFHU ZHUH WUHDWHG ZLWK WUDQVSHULQHDO LQWHUVWLWLDO ORZ GRVH UDWH EUDFK\WKHUDS\ %7  XVLQJ WKH UHDO WLPH LQWUDRSHUDWLYH 3UR6HHG WHFKQLTXH EHWZHHQ 1RYHPEHU  DQG 2FWREHU  0HGLDQIROORZXSZDVPRQWKV 3DWLHQWVZHUHVWUDWLᚏ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ᚏQHGXVLQJWKH$6752 DQG$67523KRHQL[FRQVHQVXVGHᚏQLWLRQV Results: 7KHPHDQLQWUDRSHUDWLYH'WRWKHSURVWDWH&793 ZDV*\ *\ IDOOLQJWR*\*\ RQWKH3,'VFDQ7KHPHDQLQWUDRSHUDWLYH &7939ZDV IDOOLQJWR DW3,'7KHPHDQ9 IRUSURVWDWH&793 ZDV DQG DWLPSODQWDQGSRVW LPSODQWUHVSHFWLYHO\7KHPHDQ&7939ZDV DWLPSODQWULVLQJ WR SRVWLPSODQW7KHPHDQLQWUDRSHUDWLYHSURVWDWHPDUJLQ&7930  ' ZDV *\ *\  IDOOLQJ WR *\ *\  DW 3,'   SDWLHQWV  UHFHLYHG D 3,' ' ุ*\ WR WKH &793 7KH 36$ UHODSVH UDWH ZDV SDWLHQWV XVLQJERWKGHᚏQLWLRQV2QO\SDWLHQWUHFHLYHG*\WRWKHSRVW LPSODQW &793 QHLWKHU UHODSVHG ELRFKHPLFDOO\ 7KH UHFDWKHWHULVDWLRQ UDWH ZDV 7KHVWULFWXUHUDWHZDV Conclusions: )ROORZLQJWKLVVWXG\ZHZRXOGUHFRPPHQGDQLQWUDRSHUDWLYH' WR WKH &793 RI *\ %\ GRLQJ WKLV WKH LQWUDRSHUDWLYH SURVWDWH PDUJLQ &79 30 'RI*\ZDVDFKLHYHGZKLFKJDYHDSRVWLPSODQW'WRWKHSURVWDWH ุ*\ LQ  SDWLHQWV 7KH ORZ UHODSVH UDWH LQ WKLV JURXS DFNQRZOHGJHV WKH LPSRUWDQFHRIWKH*\'WRWKH3,'&793DVDTXDOLW\VWDQGDUG7KLVGRVH LVZHOOWROHUDWHG

615

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616

RE-IMPLANTATION AFTER INSUFFICIENT PRIMARY 125-I PERMANENT BRACHYTHERAPY OF PROSTATE CANCER

(QJHOHU'63XWRUD33ODVVZLOP/6HHOHQWDJ::6FKLHIHU+ 6FKPLG+3 1 Cantonal Hospital of St. Gallen, Dept. of Urology, St. Gallen, Switzerland, 2 Cantonal Hospital of St. Gallen, Dept. of Radio-Oncology, St. Gallen, Switzerland

Results: 3DWLHQWV DJHG ื   SDWLHQWV  KDG VPDOOHU WXPRXUV S    ZLWK ORZHULQLWLDO36$YDOXHVS FRPSDUHGWRSDWLHQWVDJHG!SDWLHQWV  7KH  \HDU '66 DQG 26 UDWHV  &RQᚏGHQFH ,QWHUYDOV  ZHUH    DQG IRUDJHืDQG DQG IRUDJH!7KH GLᚎHUHQFH LQ '66 UDWHV ZDV QRW VLJQLᚏFDQW 7R DGMXVW IRU SRWHQWLDO FRQIRXQGLQJ IDFWRUV DQG EDVHOLQH GLᚎHUHQFHV D PXOWLYDULDWH &R[5HJUHVVLRQ DQDO\VLV ZDV SHUIRUPHG$JHVKRZHGDQRQVLJQLᚏFDQW+D]DUG5DWLR+5 RI&, S  6LJQLᚏFDQFHZDVUHDFKHGIRUWKHYDULDEOHV7VWDJH+5 &,S  ,QLWLDO36$+5&,S DQG *OHDVRQVFRUH+5&, )LJXUH.DSODQ0HLHUFXUYHRIDJH DQGGLVHDVHVSHFLᚏFVXUYLYDO Conclusions: 7KHUHVXOWV\HDUVDIWHUEUDFK\WKHUDS\DUHH[FHOOHQWIRUSDWLHQWV DJHG\HDUVDQG\RXQJHUDVZHOODVIRUSDWLHQWVDJHGRYHU\HDUV2QO\WKH WXPRXU FKDUDFWHULVWLFV SUHGLFWHG IRU SURVWDWH FDQFHU VXUYLYDO :LWK UHVSHFW WR FDQFHUFXUDELOLW\DJHDWSURVWDWHFDQFHUGLDJQRVLVGRHVQRWQHHGEHDUHVWULFWLRQ IRUWUHDWPHQWZLWKEUDFK\WKHUDS\

614

RECOMMENDATIONS FOR REAL TIME BRACHYTHERAPY PRESCRIPTIONS USING ESTRO/EAU/ EORTC 2007 VOLUME DEFINITIONS TO REDUCE THE CHANCE OF PSA FAILURE

'DOODV1/0DORQH35-RQHV$'RJJDUW$--RQHV-&5RJHUV3% 1 Royal Berkshire Hospital, Berkshire Cancer Centre, Reading, United Kingdom, 2 Royal Berkshire Hospital, Harold Hopkins Dept. of Urology, Reading, United Kingdom Introduction & Objectives: $PLQLPXPSRVWLPSODQW'RI*\WRWKHSURVWDWH &793 UHVXOWVLQVXSHULRUIUHHGRPIURPELRFKHPLFDOIDLOXUH7RGDWHWKHUHLVQR UHFRPPHQGHGUHDOWLPHLQWUDRSHUDWLYH'VSHFLᚏHGWRDFKLHYHWKLV:HDQDO\VHG WKHLQWUDRSHUDWLYHDQGSRVWLPSODQWGRVLPHWU\3,' XVLQJWKH(6752($8(257& UHFRPPHQGDWLRQVDQGUHSRUWRXUH[SHULHQFHRIWKH'999 WR WKH &793 DQG WKH ' WR WKH SURVWDWH PDUJLQ &7930  WR VHH ZKDW LQWUD RSHUDWLYH&793GRVHZRXOGDFKLHYH*\SRVWLPSODQW

Introduction & Objectives: 2QO\ IHZ GDWD H[LVW UHJDUGLQJ RXWFRPH RI UH LPSODQWDWLRQ5, DIWHULQVXᚑFLHQWSULPDU\,SHUPDQHQWSURVWDWHEUDFK\WKHUDS\ %7 :HGHVFULEHWKHUHVXOWVLQIRXUSDWLHQWVXQGHUJRLQJ5,EDVHGRQLQVXᚑFLHQW GRVHFRYHUDJHDIWHUWKHLUSULPDU\SURFHGXUH Material & Methods: )URP  WR  ZH WUHDWHG  SDWLHQWV ZLWK %7 DW RXU LQVWLWXWLRQ 'RVLPHWULF YHULᚏFDWLRQ RI &705,IXVLRQ LPDJHV ZDV GRQH  WR  ZHHNV DIWHU LPSODQWDWLRQ ,I DQ LQVXᚑFLHQW GRVH FRYHUDJH EDVHG RQ VWDQGDUG GRVLPHWULFFULWHULDHJ9!DQG'! ZDVIRXQG5,ZDVGRQHDIWHU LQWHUGLVFLSOLQDU\GHFLVLRQ Results: ,QVXᚑFLHQW GRVH FRYHUDJH ZDV IRXQG LQ    SDWLHQWV 7DEOH   7KLV ZDV DOZD\V FDXVHG E\ GLVORFDWLRQ RU PDOSRVLWLRQLQJ RI PXOWLSOH VHHGV 5H LPSODQWDWLRQ ZDV SHUIRUPHG  WR  PRQWKV DIWHU SULPDU\ LQWHUYHQWLRQ 'RVLPHWU\ DIWHU 5, VKRZHG VXᚑFLHQW WRWDO GRVH FRYHUDJH 7KH ODWHVW IROORZXS RI DOO IRXU SDWLHQWV DW    DQG  PRQWKV UHVSHFWLYHO\ UHYHDOHG QR FRPSOLFDWLRQV )ROORZXS36$OHYHOVGLGQRWVKRZELRFKHPLFDOUHODSVH 3DWLHQW1

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Eur Urol Suppl 2010;9(2):205