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6.2-01 Association of uveitis following extracapsular cataract extraction with HLA-DQB1 restriction fragments
Abstriii t’
6. -09
HLA TYPING IN CYSTIC FIBROSIS ARTHRITIS AND HYPERTROPHIC OSTEOARTHROPATHY. PJ Rush, D Gladman A Shore, M Corey and K Anhorn, Departments of Rehabilitation, Rheumatology and Pediatrics, University of Toronto, Toronto, Ontario. Cystic fibrosis (CF), a hereditary disease characterized by abnormal secretions from exocrine glands is associated with a unique arthritis (CFA) CFA is and hypertrophic osteoarthropathy (HOA). usually episodic but a subgroup of patients develop progressive asymmetric erosive disease. This is the first study to examine the role of the major histocompatibility complex in determining CF susceptibility to the development of CFA and HOA. Using the microlymphocytotoxicity test, we HLAA,B,C,DR,DQ typed 14 patients with CFA and 8 patients with HOA and compared them to age and sexed matched controls with CF. Diagnosis of CFA and HOA was by radiograph and bone scan. The HLAA,B,C,D frequencies of the total CF group (44 patients) overall did not differ from normal Analysis of HLA between laboratory controls. patients with CFA or HOA with their controls also did not show any significant differences in HLA frequencies. We conclude that HLA type is not a factor in CF susceptibility to CFA or HOA.
6.2-01
CA= ASSOCIATICNOF UVEITIS FOLLWIM3 ExTiww?w Eixmrdmm WIlw qA-DQBl E Casilio-LpMrdo , AA rtments of Immmopathology’ Cleqhnd Clinic Foundation and Ciba-Corning Diagkstics , Cleveland, OH. It has been suggested that weitis following extracapsular cataract extraction may be due to an autoismne reaction to residual lens material. P. acnes, recovered from the eyes of some uveitis patients, hae adjwant properties and may promote sensitization to lens protein. We have investigated a genetic predisposition to this condition. LlNA from 19 uveitis pa$f;ti&,f3 cataract surgery patients who did not have weitis individuals was tested with an BLkLQEU probe. Thc distribut on of bands produced by digestion with BRM HI, PVU II and E(X RV was significantly different amng the 3 groups (Table 1). Uveitis correlated with the presence of the 2.5 I& BiW HI and 6.9 Kb PW II bands, and the absence of a 6.1 Kb EC0 RV bamd (Table 1). ‘Ihe results indicate that susceptibility to this iridocyclitis may be associated with the IZLA-W region. This correlation has been reported elsewhere for peqhigus vulgaris. Tcrhle 1 I Cataracts 1 Uveitis Pts. IP value .Eliw HI I N0rma1s I I I
;zg”’ War
a: 2.5 Kb
1I 4f20
b : 6 . 9 Kb
9/23
c: 6.1
xb
17/19
< .OOOl
6. -09
HLA TYPING IN CYSTIC FIBROSIS ARTHRITIS AND HYPERTROPHIC OSTEOARTHROPATHY. PJ Rush, D Gladman A Shore, M Corey and K Anhorn, Departments of Rehabilitation, Rheumatology and Pediatrics, University of Toronto, Toronto, Ontario. Cystic fibrosis (CF), a hereditary disease characterized by abnormal secretions from exocrine glands is associated with a unique arthritis (CFA) CFA is and hypertrophic osteoarthropathy (HOA). usually episodic but a subgroup of patients develop progressive asymmetric erosive disease. This is the first study to examine the role of the major histocompatibility complex in determining CF susceptibility to the development of CFA and HOA. Using the microlymphocytotoxicity test, we HLAA,B,C,DR,DQ typed 14 patients with CFA and 8 patients with HOA and compared them to age and sexed matched controls with CF. Diagnosis of CFA and HOA was by radiograph and bone scan. The HLAA,B,C,D frequencies of the total CF group (44 patients) overall did not differ from normal Analysis of HLA between laboratory controls. patients with CFA or HOA with their controls also did not show any significant differences in HLA frequencies. We conclude that HLA type is not a factor in CF susceptibility to CFA or HOA.
6.2-01
CA= ASSOCIATICNOF UVEITIS FOLLWIM3 ExTiww?w Eixmrdmm WIlw qA-DQBl E Casilio-LpMrdo , AA rtments of Immmopathology’ Cleqhnd Clinic Foundation and Ciba-Corning Diagkstics , Cleveland, OH. It has been suggested that weitis following extracapsular cataract extraction may be due to an autoismne reaction to residual lens material. P. acnes, recovered from the eyes of some uveitis patients, hae adjwant properties and may promote sensitization to lens protein. We have investigated a genetic predisposition to this condition. LlNA from 19 uveitis pa$f;ti&,f3 cataract surgery patients who did not have weitis individuals was tested with an BLkLQEU probe. Thc distribut on of bands produced by digestion with BRM HI, PVU II and E(X RV was significantly different amng the 3 groups (Table 1). Uveitis correlated with the presence of the 2.5 I& BiW HI and 6.9 Kb PW II bands, and the absence of a 6.1 Kb EC0 RV bamd (Table 1). ‘Ihe results indicate that susceptibility to this iridocyclitis may be associated with the IZLA-W region. This correlation has been reported elsewhere for peqhigus vulgaris. Tcrhle 1 I Cataracts 1 Uveitis Pts. IP value .Eliw HI I N0rma1s I I I
;zg”’ War
a: 2.5 Kb
1I 4f20
b : 6 . 9 Kb
9/23
c: 6.1
xb
17/19
< .OOOl