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62. Video-polygraphic features of myoclonic epilepsy in down syndrome with Alzheimer’s disease
Society Proceedings / Clinical Neurophysiology 124 (2013) e189–e223
e203
NREM) and wakefulness, and to assess relationship between sleep EEG modifications and subsequent variations in wakefulness EEG. 8 patients AD, 13 MCI and 9 elderly healthy people performed one-night sleep PSG recordings (19 cortical electrods, EOG, EMG) and wakefulness EEG recordings (5 min with eyes open and 5 min with eyes closed). Analyses of EEG topography of wakefulness, REM and NREM sleep suggest significant differences between MCI groups vs. controls within the alpha band, in terms of lower EEG activity within this frequency range in patients in occipital and temporal derivations compared to controls. Although preliminary, data of EEG topography seems showing the same functional variations both in sleep and wakefulness. Hence, the observed slowing may be an electrophysiological evidence of neurodegenerative processes at a cortical level.
EEG data were recorded in 29 acute stroke, 29 Alzheimer’s disease, 29 mild cognitive impairment patients, and 29 cognitively intact elderly subjects. Stroke patients were age matched with the other groups, they showed a mild cognitive decline. EEG recordings were performed from the 20th to 30th days from the first ischemic or hemorrhagic acute event. LORETA was used for source estimation. Compared to the other groups, the stroke patients were characterized by a greater power of widespread cortical sources of delta (1–4 Hz) and theta (4–8 Hz) rhythms (p < 0.05). Abnormal cortical sources of delta and theta rhythms reflect the effects of stroke on cortical neural synchronization. The present study motivates future research evaluating the clinical value of delta sources for the prediction of the patients’ recovery and possible cognitive symptoms.
doi:10.1016/j.clinph.2013.06.088
doi:10.1016/j.clinph.2013.06.090
62. Video-polygraphic features of myoclonic epilepsy in down syndrome with Alzheimer’s disease—V. Demaio, G. d’Orsi, M.S. Aniello, S. Ottaviano, M. Minervini, L.M. Specchio, Study group on Epilepsy and Dementia in Down syndrome Collaborators (19): G. d’Orsi, E. Carapelle, F. Pacillo, M.G. Pascarella, M. Trivisano, A. Lopopolo, M.T. Di Claudio, L.M. Specchio, G. De Stefano, F. Merla, D. Seripa, M. Falcone, T. Francavilla, C. Luisi, A. La Neve, V. Demaio, M.S. Aniello, S. Ottaviano, M. Minervini, P. Salatto (Bisceglie BT, Foggia)
64. Resting state cortical electroencephalographic rhythms are related to cerebral hypometabolism in subjects with Alzheimer’s Disease—R. Lizio, E. Salvatore, A. Caroli, N. Marzano, C. Del Percio, G. Tedeschi, P. Montella, G. Antonio, E. Fabrizio, G.B. Frisoni, A. Soricelli, C. Babiloni, P.M. Rossini (Roma, Naples, Brescia)
Little is known about the video-polygraphic features of senile myoclonic epilepsy, a myoclonic epilepsy associated with Alzhemeir’s disease in adult Down patients. Ten patients (M/F: 4/6), 51– 70 years old (median 54.6 years), were submitted to clinical and neurophysiological (polygraphic recording with jerk-locked backaveraging) investigation. Three clinical-polygraphic phases emerged. The first phase was characterized by a late onset (>50 yrs) of a slowly progressive cognitive decline associated with generalized epileptiform abnormalities during sleep. After about one year, there was a gradual onset of second phase with a worsening of cognitive disorders associated with myoclonic seizures, usually occurred on awakening, and/or occasional and apparently generalized tonic-clonic seizures. Polygraphic features showed generalized fast spike-waves with bilateral myoclonic jerks, especially at awakenings. Finally, a third phase followed with dementia, ataxia, myoclonus and photosensitivity with rhythmic myoclonic jerks at a frequency of 12– 24 Hz. Burst-locked electroencephalographic averaging generated a controlateral positive–negative central transient preceding the myoclonus EMG discharge by 20–24 ms, compatible with a cortical origin. Our patients showed a distinctive clinical - polygraphic picture (myoclonus, epileptic seizures, signs of neurological deterioration, particularly dementia and ataxia) suggestive of a progressive myoclonic epilepsy. doi:10.1016/j.clinph.2013.06.089
63. Resting state cortical electroencephalographic rhythms in acute stroke patients—F. Infarinato, C. Del Percio, R. Lizio, P. Sale, M. Franceschini, V. Lombardi, F. Orzi, P.M. Rossini, C. Babiloni (Rome) Patients suffering from Alzheimer’s disease, Parkinson disease with dementia, and diffuse cerebrovascular dementia show different features of cortical sources of resting state electroencephalographic (EEG) rhythms (Babiloni et al., 2004, 2011). Here, we tested the hypothesis that stroke patients are characterized by peculiar abnormalities of these rhythms. Resting state eyes-closed
Alzheimer’s disease (AD) patients show abnormal cortical sources of resting state EEG rhythms, especially at delta (1–4 Hz) and alpha (8–13 Hz) bands. Here we hypothesized that this abnormality is correlated to impaired brain metabolism as a sign of AD neurodegeneration. Eyes-closed resting EEG data were recorded in 20 Alzheimer’s disease (AD), and in 35 healthy elderly (Nold) subjects. FDG-Positron Emission Tomography (PET) was only recorded in the AD patients. EEG cortical sources and a standard index of cortical hypometabolism (PALZ) were computed (PALZ includes temporal and parietal association cortices and some lateral prefrontal areas). Compared to the Nold subjects, the AD patients showed abnormal widespread cortical sources of delta (1–4 Hz) and alpha (8–10 Hz) rhythms (p < 0.05). Noteworthy, there was a positive correlation in AD patients between global delta sources and PALZ values (p < 0.05). Abnormal cortical sources of delta rhythms are correlated to cortical hypometabolism in AD patients. Cortical sources of resting state delta rhythms in AD patients reflect AD neurodegeneration processes. doi:10.1016/j.clinph.2013.06.091
65. Cortical sources of resting state EEG rhythms reflect disease progression over 1 year in mild cognitive impairment and Alzheimer’s disease patients—R. Lizio, C. Babiloni, C. Del Percio, N. Marzano, A. Soricelli, E. Salvatore, R. Ferri, F. Cosentino, G. Tedeschi, P. Montella, S. Marino, G. Rodriguez, F. Nobili, F. Vernieri, F. Ursini, C. Mundi, G.B. Frisoni, P.M. Rossini (Rome, Naples, Troina EN, Messina, Genoa, Foggia, Brescia) Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with mild cognitive impairment (MCI) and in patients with Alzheimer’s disease (AD). Here, we tested the hypothesis that they reflect disease progression for future clinical trials. Resting state eyes-closed EEG data were recorded in 54 amnesic MCI subjects and in 88 mild AD patients at baseline and at 1-year follow up. LORETA was used for data analysis. In the mild AD patients, the follow-up EEG recordings showed increased power of widespread delta sources as well as decreased power of widespread alpha and posterior beta 1 sources (p < 0.05). In the MCI subjects, these recordings indicated a decreased power of posterior alpha 1 and alpha 2 sources (p < 0.05). Cortical sources of EEG
e203
NREM) and wakefulness, and to assess relationship between sleep EEG modifications and subsequent variations in wakefulness EEG. 8 patients AD, 13 MCI and 9 elderly healthy people performed one-night sleep PSG recordings (19 cortical electrods, EOG, EMG) and wakefulness EEG recordings (5 min with eyes open and 5 min with eyes closed). Analyses of EEG topography of wakefulness, REM and NREM sleep suggest significant differences between MCI groups vs. controls within the alpha band, in terms of lower EEG activity within this frequency range in patients in occipital and temporal derivations compared to controls. Although preliminary, data of EEG topography seems showing the same functional variations both in sleep and wakefulness. Hence, the observed slowing may be an electrophysiological evidence of neurodegenerative processes at a cortical level.
EEG data were recorded in 29 acute stroke, 29 Alzheimer’s disease, 29 mild cognitive impairment patients, and 29 cognitively intact elderly subjects. Stroke patients were age matched with the other groups, they showed a mild cognitive decline. EEG recordings were performed from the 20th to 30th days from the first ischemic or hemorrhagic acute event. LORETA was used for source estimation. Compared to the other groups, the stroke patients were characterized by a greater power of widespread cortical sources of delta (1–4 Hz) and theta (4–8 Hz) rhythms (p < 0.05). Abnormal cortical sources of delta and theta rhythms reflect the effects of stroke on cortical neural synchronization. The present study motivates future research evaluating the clinical value of delta sources for the prediction of the patients’ recovery and possible cognitive symptoms.
doi:10.1016/j.clinph.2013.06.088
doi:10.1016/j.clinph.2013.06.090
62. Video-polygraphic features of myoclonic epilepsy in down syndrome with Alzheimer’s disease—V. Demaio, G. d’Orsi, M.S. Aniello, S. Ottaviano, M. Minervini, L.M. Specchio, Study group on Epilepsy and Dementia in Down syndrome Collaborators (19): G. d’Orsi, E. Carapelle, F. Pacillo, M.G. Pascarella, M. Trivisano, A. Lopopolo, M.T. Di Claudio, L.M. Specchio, G. De Stefano, F. Merla, D. Seripa, M. Falcone, T. Francavilla, C. Luisi, A. La Neve, V. Demaio, M.S. Aniello, S. Ottaviano, M. Minervini, P. Salatto (Bisceglie BT, Foggia)
64. Resting state cortical electroencephalographic rhythms are related to cerebral hypometabolism in subjects with Alzheimer’s Disease—R. Lizio, E. Salvatore, A. Caroli, N. Marzano, C. Del Percio, G. Tedeschi, P. Montella, G. Antonio, E. Fabrizio, G.B. Frisoni, A. Soricelli, C. Babiloni, P.M. Rossini (Roma, Naples, Brescia)
Little is known about the video-polygraphic features of senile myoclonic epilepsy, a myoclonic epilepsy associated with Alzhemeir’s disease in adult Down patients. Ten patients (M/F: 4/6), 51– 70 years old (median 54.6 years), were submitted to clinical and neurophysiological (polygraphic recording with jerk-locked backaveraging) investigation. Three clinical-polygraphic phases emerged. The first phase was characterized by a late onset (>50 yrs) of a slowly progressive cognitive decline associated with generalized epileptiform abnormalities during sleep. After about one year, there was a gradual onset of second phase with a worsening of cognitive disorders associated with myoclonic seizures, usually occurred on awakening, and/or occasional and apparently generalized tonic-clonic seizures. Polygraphic features showed generalized fast spike-waves with bilateral myoclonic jerks, especially at awakenings. Finally, a third phase followed with dementia, ataxia, myoclonus and photosensitivity with rhythmic myoclonic jerks at a frequency of 12– 24 Hz. Burst-locked electroencephalographic averaging generated a controlateral positive–negative central transient preceding the myoclonus EMG discharge by 20–24 ms, compatible with a cortical origin. Our patients showed a distinctive clinical - polygraphic picture (myoclonus, epileptic seizures, signs of neurological deterioration, particularly dementia and ataxia) suggestive of a progressive myoclonic epilepsy. doi:10.1016/j.clinph.2013.06.089
63. Resting state cortical electroencephalographic rhythms in acute stroke patients—F. Infarinato, C. Del Percio, R. Lizio, P. Sale, M. Franceschini, V. Lombardi, F. Orzi, P.M. Rossini, C. Babiloni (Rome) Patients suffering from Alzheimer’s disease, Parkinson disease with dementia, and diffuse cerebrovascular dementia show different features of cortical sources of resting state electroencephalographic (EEG) rhythms (Babiloni et al., 2004, 2011). Here, we tested the hypothesis that stroke patients are characterized by peculiar abnormalities of these rhythms. Resting state eyes-closed
Alzheimer’s disease (AD) patients show abnormal cortical sources of resting state EEG rhythms, especially at delta (1–4 Hz) and alpha (8–13 Hz) bands. Here we hypothesized that this abnormality is correlated to impaired brain metabolism as a sign of AD neurodegeneration. Eyes-closed resting EEG data were recorded in 20 Alzheimer’s disease (AD), and in 35 healthy elderly (Nold) subjects. FDG-Positron Emission Tomography (PET) was only recorded in the AD patients. EEG cortical sources and a standard index of cortical hypometabolism (PALZ) were computed (PALZ includes temporal and parietal association cortices and some lateral prefrontal areas). Compared to the Nold subjects, the AD patients showed abnormal widespread cortical sources of delta (1–4 Hz) and alpha (8–10 Hz) rhythms (p < 0.05). Noteworthy, there was a positive correlation in AD patients between global delta sources and PALZ values (p < 0.05). Abnormal cortical sources of delta rhythms are correlated to cortical hypometabolism in AD patients. Cortical sources of resting state delta rhythms in AD patients reflect AD neurodegeneration processes. doi:10.1016/j.clinph.2013.06.091
65. Cortical sources of resting state EEG rhythms reflect disease progression over 1 year in mild cognitive impairment and Alzheimer’s disease patients—R. Lizio, C. Babiloni, C. Del Percio, N. Marzano, A. Soricelli, E. Salvatore, R. Ferri, F. Cosentino, G. Tedeschi, P. Montella, S. Marino, G. Rodriguez, F. Nobili, F. Vernieri, F. Ursini, C. Mundi, G.B. Frisoni, P.M. Rossini (Rome, Naples, Troina EN, Messina, Genoa, Foggia, Brescia) Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with mild cognitive impairment (MCI) and in patients with Alzheimer’s disease (AD). Here, we tested the hypothesis that they reflect disease progression for future clinical trials. Resting state eyes-closed EEG data were recorded in 54 amnesic MCI subjects and in 88 mild AD patients at baseline and at 1-year follow up. LORETA was used for data analysis. In the mild AD patients, the follow-up EEG recordings showed increased power of widespread delta sources as well as decreased power of widespread alpha and posterior beta 1 sources (p < 0.05). In the MCI subjects, these recordings indicated a decreased power of posterior alpha 1 and alpha 2 sources (p < 0.05). Cortical sources of EEG