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651. Effect of Bright Light Therapy on White Matter Abnormalities following a Mild Traumatic Brain Injury
Biological Psychiatry
Friday Abstracts
and reserve; there may be potential for affecting change to higher-demand tasks with longer tDCS treatments, advanced targeting approaches, or alternate modalities. Supported By: Shanghai Mental health institute, internal funds; CSC. Keywords: tDCS, Working memory, Neuroimaging, Randomized controlled trial, Schiizophrenia
651. Effect of Bright Light Therapy on White Matter Abnormalities following a Mild Traumatic Brain Injury Sahil Bajaj1, Anna Alkozei1, and William Killgore2 University of Arizona, 2University of Arizona, Department of Psychiatry
1
Background: White matter (WM) integrity still needs to be explored to determine the structural and cognitive impairment following an mTBI. We aim to explore such WM abnormalities and analyze the impact of morning bright (amber/blue) light therapy (ALT/BLT) on WM integrity. Methods: 39 healthy-controls (HCs) and 28 mTBI survivors (before and after six weeks of either ALT or BLT) underwent diffusion tensor imaging. Raw quantitative anisotropy (QA), normalized QA (NQA) and isotropic (ISO) diffusion were estimated for 11 regions of interest (ROIs): the dorsal-lateral prefrontal cortex (DLPFC), genu, splenium and body of the corpus callosum (CC), the left/right uncinate fasciculus (L/R UF), the left/right superior longitudinal fasciculus (L/R SLF), the left/right anterior corona radiata (L/R ACR) and the thalamus. Results: Using two-sample t-tests (p , 0.05), we found that all ROIs (a) had significantly higher QA and (b) except the splenium, the LSLF and the thalamus, had significantly higher ISO for mTBI than HCs. There was no significant improvement in NQA for any ROI following ALT. Following BLT, four ROIs (the body of CC, the L/R UF and the LACR) showed significant decrease in NQA (paired t-test, p , 0.05) and three ROIs (the body of CC and the L/R UF) showed significant (p , 0.05) negative correlation between residuals of NQA and residuals of delayed memory Repeatable Battery for the Assessment of Neuropsychological Status scores. Conclusions: BLT helped to improve WM integrity and behavior of mTBI survivors, indicating that BLT can be an effective treatment for mTBI survivors. Supported By: DOD W81XWH-11-1-0056 Keywords: Sleep Disorders, Diffusion Tensor Imaging (DTI), Mild Traumatic Brain Injury, Light Therapy, Anisotropic Diffusion
652. Novel Complementary and Alternative Mindfulness Based Intervention: Therapeutic Approach to Manage Substance Use Disorders and Posttraumatic Stress Disorder Sajoy Varghese1, Sheena Varghese2, Anish Chackochan3, Maju Koola4, Sandeep Saini5, and Alex Zachariah6 1 Jesse Brown VA Medical Center, 2Department of Physical Therapy, RML Specialty Hospital, 33PASS Program,
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4
Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, 5College of Physiotherapy, Christian Medical College, Ludhiana, India, 6National Institute of Health/National Institute of Aging Background: Relapse is a core feature of substance use disorders (SUD). Intentional slower breathing or "intentional respiratory rate variability" (IRRV) by the aid of Rhemercise (a new exercise manual) may be an effective therapeutic approach for well-being. IRRV can increase Heart Rate Variability (HRV) and that HRV is the biomarker of overall well-being. We hypothesize that increased HRV could decrease craving creating relapse prevention strategy. We hypothesize that IRRV increases HRV. Methods: Fitness Assessment Chair Test (FACT) performed at the College of Physiotherapy, Christian Medical College, Ludhiana, Punjab, India. The research involved 15 physiotherapy students and interns 19-25. The progression of fitness was assessed using the FACT, over 3 weeks. The statistical F test, ANOVA, was used to compare the data and post hoc test, Tukey’s test, to compare the pairwise count. This small sample study showed significant changes in week 1, week 2, and week 3 readings. Results: F test (ANOVA) is used to compare the counts. Calculated Test statistics (F test) value 20.447 is more than the table value 3.220. So the difference is significant. Null Hypothesis is rejected there is significant change in week 1, week 2 and week 3 readings with respect to 10 seconds readings. Conclusions: FACT is a form of Rhemercise that could increase physical well-being. We hypothesize that IRRV by YR can increase HRV and subsequently decrease craving for illicit drugs. IRRV could be a therapeutic approach to prevent relapses in people with SUD and PTSD. Keywords: YoHA Rhemercise, Substance Use Disorder, Posttraumatic Stress Disorder, IntentionalRrespiratory Rate Variability, Heart Rate Variability
653. Can What Goes up Come Back Down? The Effects of DCS on Individual Differences in Relapse of Fear Gabrielle King1, Bronwyn Graham2, and Rick Richardson2 1 University of New South Wales, Psychology, 2University of New South Wales
Background: We have recently demonstrated that vulnerability to relapse of fear is related to individual differences in the rate of extinction; animals with a slow rate of extinction are more vulnerable to relapse than animals with a fast rate of extinction. Here we examined individual differences in the efficacy of D-Cycloserine (DCS) in reducing relapse in a setting where both groups show marked relapse. Methods: Experimentally-naïve adult male rats received pairings of a white noise CS with a shock US, extinction to a criterion followed by an injection of DCS or Saline, and then tested for renewal of fear. The number of blocks to reach criteria in extinction was used to classify animals as “fast” or “slow” extinguishers. CS-elicited freezing was taken as the measure of fear, and the results below are in terms of percentage of time spent freezing.
Biological Psychiatry May 15, 2017; 81:S140–S276 www.sobp.org/journal
Friday Abstracts
and reserve; there may be potential for affecting change to higher-demand tasks with longer tDCS treatments, advanced targeting approaches, or alternate modalities. Supported By: Shanghai Mental health institute, internal funds; CSC. Keywords: tDCS, Working memory, Neuroimaging, Randomized controlled trial, Schiizophrenia
651. Effect of Bright Light Therapy on White Matter Abnormalities following a Mild Traumatic Brain Injury Sahil Bajaj1, Anna Alkozei1, and William Killgore2 University of Arizona, 2University of Arizona, Department of Psychiatry
1
Background: White matter (WM) integrity still needs to be explored to determine the structural and cognitive impairment following an mTBI. We aim to explore such WM abnormalities and analyze the impact of morning bright (amber/blue) light therapy (ALT/BLT) on WM integrity. Methods: 39 healthy-controls (HCs) and 28 mTBI survivors (before and after six weeks of either ALT or BLT) underwent diffusion tensor imaging. Raw quantitative anisotropy (QA), normalized QA (NQA) and isotropic (ISO) diffusion were estimated for 11 regions of interest (ROIs): the dorsal-lateral prefrontal cortex (DLPFC), genu, splenium and body of the corpus callosum (CC), the left/right uncinate fasciculus (L/R UF), the left/right superior longitudinal fasciculus (L/R SLF), the left/right anterior corona radiata (L/R ACR) and the thalamus. Results: Using two-sample t-tests (p , 0.05), we found that all ROIs (a) had significantly higher QA and (b) except the splenium, the LSLF and the thalamus, had significantly higher ISO for mTBI than HCs. There was no significant improvement in NQA for any ROI following ALT. Following BLT, four ROIs (the body of CC, the L/R UF and the LACR) showed significant decrease in NQA (paired t-test, p , 0.05) and three ROIs (the body of CC and the L/R UF) showed significant (p , 0.05) negative correlation between residuals of NQA and residuals of delayed memory Repeatable Battery for the Assessment of Neuropsychological Status scores. Conclusions: BLT helped to improve WM integrity and behavior of mTBI survivors, indicating that BLT can be an effective treatment for mTBI survivors. Supported By: DOD W81XWH-11-1-0056 Keywords: Sleep Disorders, Diffusion Tensor Imaging (DTI), Mild Traumatic Brain Injury, Light Therapy, Anisotropic Diffusion
652. Novel Complementary and Alternative Mindfulness Based Intervention: Therapeutic Approach to Manage Substance Use Disorders and Posttraumatic Stress Disorder Sajoy Varghese1, Sheena Varghese2, Anish Chackochan3, Maju Koola4, Sandeep Saini5, and Alex Zachariah6 1 Jesse Brown VA Medical Center, 2Department of Physical Therapy, RML Specialty Hospital, 33PASS Program,
S264
4
Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, 5College of Physiotherapy, Christian Medical College, Ludhiana, India, 6National Institute of Health/National Institute of Aging Background: Relapse is a core feature of substance use disorders (SUD). Intentional slower breathing or "intentional respiratory rate variability" (IRRV) by the aid of Rhemercise (a new exercise manual) may be an effective therapeutic approach for well-being. IRRV can increase Heart Rate Variability (HRV) and that HRV is the biomarker of overall well-being. We hypothesize that increased HRV could decrease craving creating relapse prevention strategy. We hypothesize that IRRV increases HRV. Methods: Fitness Assessment Chair Test (FACT) performed at the College of Physiotherapy, Christian Medical College, Ludhiana, Punjab, India. The research involved 15 physiotherapy students and interns 19-25. The progression of fitness was assessed using the FACT, over 3 weeks. The statistical F test, ANOVA, was used to compare the data and post hoc test, Tukey’s test, to compare the pairwise count. This small sample study showed significant changes in week 1, week 2, and week 3 readings. Results: F test (ANOVA) is used to compare the counts. Calculated Test statistics (F test) value 20.447 is more than the table value 3.220. So the difference is significant. Null Hypothesis is rejected there is significant change in week 1, week 2 and week 3 readings with respect to 10 seconds readings. Conclusions: FACT is a form of Rhemercise that could increase physical well-being. We hypothesize that IRRV by YR can increase HRV and subsequently decrease craving for illicit drugs. IRRV could be a therapeutic approach to prevent relapses in people with SUD and PTSD. Keywords: YoHA Rhemercise, Substance Use Disorder, Posttraumatic Stress Disorder, IntentionalRrespiratory Rate Variability, Heart Rate Variability
653. Can What Goes up Come Back Down? The Effects of DCS on Individual Differences in Relapse of Fear Gabrielle King1, Bronwyn Graham2, and Rick Richardson2 1 University of New South Wales, Psychology, 2University of New South Wales
Background: We have recently demonstrated that vulnerability to relapse of fear is related to individual differences in the rate of extinction; animals with a slow rate of extinction are more vulnerable to relapse than animals with a fast rate of extinction. Here we examined individual differences in the efficacy of D-Cycloserine (DCS) in reducing relapse in a setting where both groups show marked relapse. Methods: Experimentally-naïve adult male rats received pairings of a white noise CS with a shock US, extinction to a criterion followed by an injection of DCS or Saline, and then tested for renewal of fear. The number of blocks to reach criteria in extinction was used to classify animals as “fast” or “slow” extinguishers. CS-elicited freezing was taken as the measure of fear, and the results below are in terms of percentage of time spent freezing.
Biological Psychiatry May 15, 2017; 81:S140–S276 www.sobp.org/journal