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71 THE ROLE OF INTRACELLULAR KINASES IN AGEING ERECTILE DYSFUNCTION
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Poster Session 5 SEX, TESTOSTERONE AND THE PROSTATE Saturday, 17 April, 14.15-15.45, Genoa Room
71
THE ROLE OF INTRACELLULAR KINASES IN AGEING ERECTILE DYSFUNCTION
&DVWHOD$6RDUHV55RFKD)9HQGHLUD3&RVWD& 1 Faculty of Medicine of The University of Porto, Dept. of Laboratory for Molecular Cell Biology, Porto, Portugal, 2Faculty of Medicine of The University of Porto, Dept. of Biochemistry, Porto, Portugal, 3Hospital S. Joao, Dept. of Urology, Porto, Portugal Introduction & Objectives: (UHFWLOH G\VIXQFWLRQ (' LV D FRPPRQ SUREOHP LQ DJHG PHQ KRZHYHU LW KDV QHYHU EHHQ HOXFLGDWHG WKH HᚎHFWV RI DJLQJ LQ WKH GHUHJXODWLRQ RI FDYHUQRVDO LQWUDFHOOXODU PROHFXODU HYHQWV :H HYDOXDWHG LQ DQ H[SHULPHQWDOPRGHOFDYHUQRVDOWLVVXHUHPRGHOLQJFDSDELOLW\DQGWKHGRZQVWUHDP DFWLYDWLRQRIWKHHᚎHFWRUSURWHLQV0LWRJHQ$FWLYDWHG3URWHLQSNLQDVH S 0$3. DQGSKRVSKDWLG\OLQRVLWRONLQDVH 3,.$NW Material & Methods: 0DOH :LVWDU UDWV ZHUH GLYLGHG LQ DJLQJ 0DOH :LVWDU UDWV ZHUHGLYLGHGLQJURXSVRIPRQWKVROG3HQLOHWLVVXHZDVSURFHVVHG IRUSURWHLQLVRODWLRQDQGLPPXQRKLVWRFKHPLFDODQDO\VLV&DYHUQRVDOYLDELOLW\ZDV HYDOXDWHGE\781(/DVVD\DQGSUROLIHUDWLRQZDVDQDO\]HGE\LPPXQRKLVWRFKHPLFDO GHWHFWLRQRI3UROLIHUDWLQJ&HOO1XFOHDU$QWLJHQ 3&1$ ,PPXQRORFDOL]DWLRQRIWKH DFWLYDWHGIRUPVRIS0$3.DQG$NWZHUHDVVHVVHGLQVLWXDQGFKDQJHVLQ WKHLU SKRVSKRU\ODWLRQ ZHUH TXDQWLᚏHG E\ ZHVWHUQ EORWWLQJ ([WUDFHOOXODU PDWUL[ DOWHUDWLRQVZHUHDVVHVVHGE\0DVVRQWULFKURPHVWDLQLQJ Results: :H GHPRQVWUDWHG WKDW ZLWK WKH DGYDQFHPHQW RI DJH FDYHUQRVDO UHPRGHOLQJZDVDᚎHFWHGE\DQDJHGHSHQGHQWXQEDODQFHEHWZHHQDSRSWRVLVDQG SUROLIHUDWLRQ7KLVWXUQRYHUDOWHUDWLRQZDVDFFRPSDQLHGE\VLJQLᚏFDQWPRGLᚏFDWLRQV LQWKHDFWLYDWLRQSURᚏOHRIWKHGRZQVWUHDPNLQDVHS,Q\RXQJHVWFDYHUQRVDO VDPSOHVSZDVPRVWO\DFWLYDWHGDWSHULYDVFXODUVLWHVQDPHO\LQFRUSRUHDO VPRRWKPXVFOHFHOOVPHGLDWLQJFHOOVXUYLYDOSUROLIHUDWLRQ+RZHYHULQWKHHOGHUO\ S SKRVSKRU\ODWLRQ VKLIWHG WR WUDEHFXODU ᚏEUREODVWV SURPRWLQJ H[WUDFHOOXODU PDWUL[SURGXFWLRQDQGGHSRVLWLRQ1RVLJQLᚏFDQWDOWHUDWLRQVZHUHREVHUYHGLQWKH FDYHUQRVDODFWLYDWLRQSDWWHUQRI$NWZLWKDJLQJ Conclusions: :HVKRZHGWKDWZLWKWKHDGYDQFHPHQWRIDJHWKHUHLVDQXQEDODQFH EHWZHHQ DSRSWRVLV DQG SUROLIHUDWLRQ LQ HUHFWLOH WLVVXH ,Q DGGLWLRQ ZH SURYLGHG HYLGHQFHIRUWKHᚏUVWWLPHWKDWLQDJLQJFDYHUQRVDOWLVVXH WKHGRZQVWUHDPDFWLYDWLRQ SURᚏOHRISNLQDVHLVDOWHUHGFRQWULEXWLQJWRSHQLOHFHOOXODUDQGPRUSKRORJLFDO FKDQJHVZKLFKDᚎHFWHUHFWLOHIXQFWLRQLQWKHHOGHUO\
72
TESTOSTERONE DEFICIENCY AND DECREASE OF LIBIDO IN OBSTRUCTIVE SLEEP APNEA SYNDROME (OSAS) PATIENTS
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73
WITHDRAWN
74
EFFECTS OF INDUCED HYPOGONADISM IN HUMAN CORPORA CAVERNOSA: AN IMMUNOHISTOCHEMICAL AND MORPHOMETRIC APPROACH
7RPDGD,7RPDGD11HYHV' 1 Faculty of Medicine of Universidade Do Porto, Laboratory For Molecular Cell Biology, Porto, Portugal, 2S. João Central Hospital, Dept. of Urology, Porto, Portugal Introduction & Objectives: $QGURJHQVDUHHVVHQWLDOIRUWKHQRUPDOGHYHORSPHQW RISHQLVDQGWKHLUGHᚏFLHQF\OHDGVWRLPSRUWDQWVWUXFWXUDODEQRUPDOLWLHV$OWKRXJK WKHLUH[DFWUROHLQKXPDQFRUSRUDFDYHUQRVD && LVVWLOOFRQWURYHUVLDOLWLVEHOLHYHG WKDWWKH\DUHFULWLFDOIRUHUHFWLOHIXQFWLRQZKLFKLQWXUQGHSHQGVIURPWLVVXHLQWHJULW\ DQG FHOOXODU YLDELOLW\ :H DLP WR FKDUDFWHUL]H \RXQJ KXPDQ && DIWHU LQGXFHG K\SRJRQDGLVP Material & Methods: $QGURJHQGHSULYHG SHQLOH IUDJPHQWV ZHUH UHPRYHG IURP LQGLYLGXDOV VXEPLWWHG WR PDOHWRIHPDOH VH[ UHDVVLJQPHQW SURFHGXUH Q \ ZKR XQGHUJRQH DQ DQGURJHQ GHSULYDWLRQ FKHPLFDO UHJLPHQ SURWRFRO PJGHVSLURQRODFWRQHDQGPJGF\SURWHURQHDFHWDWHIRUPRIROORZHGE\ PJG HVWUDGLRO IRU PR &RQWURO SHQLOH IUDJPHQWV ZHUH UHPRYHG IURP RUJDQ GRQRUV Q \ /RFDO FRPPLWWHH RQ HWKLFV DSSURYHG DQG DXWKRUL]HG WKH VWXG\7LVVXHIUDJPHQWVZHUHᚏ[HGSDUDᚑQHPEHGGHGDQGVWDLQHGZLWK0DVVRQಬV WULFKURPH7KHLPDJHVRIWLVVXHIUDJPHQWVVWDLQHGZLWK0DVVRQಬVWULFKURPHZHUH FDSWXUHGLQDQOLJKWPLFURVFRSHDQGVXEMHFWHGWRPRUSKRPHWULFDQDO\VLVRIVPRRWK PXVFOHDQGFRQQHFWLYHWLVVXHYROXPHWULFGHQVLWLHVHPSOR\LQJ,PDJH-pVRIWZDUH 7KHLPPXQRKLVWRFKHPLFDO DOSKDDFWLQYRQ:LOOHEUDQGIDFWRUದY:IದDQGYDVFXODU HQGRWKHOLDO JURZWK IDFWRU ದ9(*) DQG GXDOLPPXQRᚐXRUHVFHQFH VWXGLHV DOSKD DFWLQY:I DQG DOSKDDFWLQ9(*) ZDV DOVR SHUIRUPHG HPSOR\LQJ DSSURSULDWHG DQWLERGLHVDQGREVHUYHGLQDOLJKWRU$SRWRPHPLFURVFRSHVUHVSHFWLYHO\ Results: $QGURJHQGHSULYHGFDYHUQRXVWLVVXHLVVWUXFWXUDOO\GLᚎHUHQWIURPQRUPDO KRUPRQDO HQYLURQPHQW H[SRVHG WLVVXH &RPSDUDWLYHO\ WR FRQWUROV DQGURJHQ ZLWKGUDZDOOHDGVWRDVLJQLᚏFDQWGHFUHDVHLQVPRRWKPXVFOHFRQWHQW WR S DQGDVLJQLᚏFDQWLQFUHDVHLQFRQQHFWLYHWLVVXHGHQVLW\ WR S $GGLWLRQDOO\WKLVWLVVXHHYLGHQFHGDQHQODUJHPHQWRIYDVFXODUVSDFHV VXJJHVWLQJ WKDW DQGURJHQ GHSULYDWLRQ LQGXFHV YDVFXODU UHPRGHOOLQJ 2YHUDOO DV HUHFWLOHIXQFWLRQGHSHQGVRQVWUXFWXUDOLQWHJULW\RI&&WKHFKDQJHVREVHUYHGLQWKLV DQGURJHQGHᚏFLHQW&&PLJKWGHᚏQLWLYHO\FRPSURPLVHYDVRGLODWDWLRQ Conclusions: 2XUUHVXOWVXQGHUOLHWKHUROHRIDQGURJHQVLQVWUXFWXUDORUJDQL]DWLRQ RI&&DQGUHSUHVHQWQHZLQVLJKWVWRXQGHUVWDQGLQJHUHFWLOHIXQFWLRQPHFKDQLVPV LQ KXPDQ $OWKRXJK PROHFXODU VWXGLHV DUH SUHVHQWO\ XQGHU DQDO\VLV LQ RUGHU WR YDOLGDWH WKHVH ᚏQGLQJV ZH FRQVLGHU WKDW SHQLOH WLVVXH UHPRYHG IURP \RXQJ DQGURJHQGHSULYHGLQGLYLGXDOVLVQRWDQDGHTXDWHPRGHORIKHDOWK\&&
75
PROSTATE SAFETY OF TESTOSTERONE REPLACEMENT THERAPY IN MALE HYPOGONADISM: INTERIM RESULTS FROM THE LARGEST INTERNATIONAL TRIAL ON INJECTABLE LONG-ACTING TESTOSTERONE UNDECANOATE INVOLVING 763 PATIENTS
%HUFHD%6%HUFHD50&RMRFDUX(0LKDHVFX7 1 Clinical Hospital C.I. Parhon IASI, Dept. of Urology and Kidney Transplant, Iasi, Romania, 2Clinic of Pneumology, Dept. of Pneumology, Iasi, Romania, 3University of Medicine and Pharmacy “gr. T. Popa”, Dept. of Physiology, Iasi, Romania
=LW]PDQQ0+DQLVFK-80DWWHUQ$-XQJZLUWK$0DJJL0 1 University Clinics, Dept. of Reproductive Medicine and Andrology, Muenster, Germany, 2Bayer Vital GmbH, Male Health Care, Leverkusen, Germany, 3Bayer Schering Pharma, Dept. of Male Health Care, Berlin, Germany, 4EMCO Private Clinic, Dept. of Urology, Bad Dürrnberg, Austria, 5University of Florence, Dept. of Sexual Medicine and Andrology, Florence, Italy
Introduction & Objectives: 7RHYDOXDWHWHVWRVWHURQHGHᚏFLHQF\DQGGHFUHDVHRI OLELGRLQREVWUXFWLYHVOHHSDSQHDV\QGURPH 26$6 SDWLHQWV Material & Methods: :H VHOHFWHG SDWLHQWV GLDJQRVHG ZLWK 26$6 DIWHU D IXOO QLJKW SROLVRPQRJUDSK\ LQ &OLQLF RI 3XOPRQDU\ 'LVHDVHV $OO UHFRUGLQJV ZHUH YDOLGDWHG DFFRUGLQJ WR $$60 $PHULFDQ $VVRFLDWLRQ RI 6OHHS 0HGLFLQH JXLGHOLQHV $OO SDWLHQWV IXOᚏOOHG %HFN 'HSUHVVLRQ ,QYHQWRU\ :H GHWHUPLQHG VHUXP WRWDO WHVWRVWHURQH OHYHO SHUIRUPHG EHWZHHQ $0 DQG $0 XWLOL]LQJ FKHPLOXPLQHVFHQFHಬVPHWKRG Results: 7KH PHDQ OHYHO RI WHVWRVWHURQH LV s QJPO FRQVLGHUHG K\SRJRQDGDOOHYHODFFRUGLQJWR($8JXLGHOLQHV0HDQRI$+, $SQHD+\SRSQHD ,QGH[ LVsSHUKRXU7KHDJHRI RIWKHVWXGLHGPHQLVRXWVLGHRIWKH SK\VLRORJLFK\SRJRQDGDOOHYHO \HDUV WKHPHDQRIDJHVEHLQJs \HDUV ROG 7KHUH ZDV D SRVLWLYH FRUUHODWLRQ EHWZHHQ WHVWRVWHURQH OHYHO DQG UHVSLUDWRU\ GLVWUHVV LQGH[ S $QDO\VHV RI WKH GDWHV UHYHDOHG DQ LQWHQVH SRVLWLYH FRUUHODWLRQ RI VHUXP WHVWRVWHURQH OHYHOV ZLWK R[\JHQ GHVDWXUDWLRQ LQGH[ 2',
Introduction & Objectives: 3URVWDWH VDIHW\ LV D FRQFHUQ LQ WHVWRVWHURQH UHSODFHPHQW WKHUDS\ 6LPXOWDQHRXVO\ EHQHᚏWV LQ WHUPV RI PHQWDO VH[XDO DQG PHWDEROLFKHDOWKKDYHWREHDFKLHYHG7KHEDODQFHEHWZHHQEHQHᚏWVDQGDGYHUVH DVSHFWVKDVWREHFDUHIXOO\HOXFLGDWHG Material & Methods: 5HVXOWVIURPDZRUOGZLGHVXUYHLOODQFHVWXG\DVVHVVLQJWKH VDIHW\DQGHᚎHFWLYHQHVVRILQMHFWDEOHORQJDFWLQJWHVWRVWHURQHXQGHFDQRDWH 78 LQ K\SRJRQDGDOPHQDLPLQJWRLQYROYHXSWRPHQDUHSUHVHQWHG'DWDIURP PHQ DJHG s \HDUV KDYLQJUHFHLYHGLQMHFWLRQVZHUHDYDLODEOHIRU WKLVLQWHULPUHSRUW78WKHUDS\ZDVDGPLQLVWHUHGIRU ದPRQWKV3DWLHQWGDWDIURP FRXQWULHVLQ(XURSH$VLD/DWLQ$PHULFDDQG$XVWUDOLDZHUHDFTXLUHG3URVWDWH VDIHW\ZDVPRQLWRUHGE\GLJLWDOUHFWDOH[DPLQDWLRQDQGDVVHVVPHQWRI36$OHYHOV 3URVWDWHELRSVLHVZHUHWDNHQDFFRUGLQJWRVWDQGDUGRIFDUH3DUDPHWHUVRIHUHFWLOH IXQFWLRQ OLELGR YLJRXUYLWDOLW\ PRRG DQG DELOLW\ WR FRQFHQWUDWH ZHUH DVVHVVHG XVLQJYDOLGDWHGWRROV3K\VLFDODQGFLUFXODWRU\SDUDPHWHUVDVZHOODVKHPDWRFULW JOXFRVHFRQWURODQGOLSLGSURᚏOHVZHUHUHFRUGHG
Eur Urol Suppl 2010;9(2):56
Poster Session 5 SEX, TESTOSTERONE AND THE PROSTATE Saturday, 17 April, 14.15-15.45, Genoa Room
71
THE ROLE OF INTRACELLULAR KINASES IN AGEING ERECTILE DYSFUNCTION
&DVWHOD$6RDUHV55RFKD)9HQGHLUD3&RVWD& 1 Faculty of Medicine of The University of Porto, Dept. of Laboratory for Molecular Cell Biology, Porto, Portugal, 2Faculty of Medicine of The University of Porto, Dept. of Biochemistry, Porto, Portugal, 3Hospital S. Joao, Dept. of Urology, Porto, Portugal Introduction & Objectives: (UHFWLOH G\VIXQFWLRQ (' LV D FRPPRQ SUREOHP LQ DJHG PHQ KRZHYHU LW KDV QHYHU EHHQ HOXFLGDWHG WKH HᚎHFWV RI DJLQJ LQ WKH GHUHJXODWLRQ RI FDYHUQRVDO LQWUDFHOOXODU PROHFXODU HYHQWV :H HYDOXDWHG LQ DQ H[SHULPHQWDOPRGHOFDYHUQRVDOWLVVXHUHPRGHOLQJFDSDELOLW\DQGWKHGRZQVWUHDP DFWLYDWLRQRIWKHHᚎHFWRUSURWHLQV0LWRJHQ$FWLYDWHG3URWHLQSNLQDVH S 0$3. DQGSKRVSKDWLG\OLQRVLWRONLQDVH 3,.$NW Material & Methods: 0DOH :LVWDU UDWV ZHUH GLYLGHG LQ DJLQJ 0DOH :LVWDU UDWV ZHUHGLYLGHGLQJURXSVRIPRQWKVROG3HQLOHWLVVXHZDVSURFHVVHG IRUSURWHLQLVRODWLRQDQGLPPXQRKLVWRFKHPLFDODQDO\VLV&DYHUQRVDOYLDELOLW\ZDV HYDOXDWHGE\781(/DVVD\DQGSUROLIHUDWLRQZDVDQDO\]HGE\LPPXQRKLVWRFKHPLFDO GHWHFWLRQRI3UROLIHUDWLQJ&HOO1XFOHDU$QWLJHQ 3&1$ ,PPXQRORFDOL]DWLRQRIWKH DFWLYDWHGIRUPVRIS0$3.DQG$NWZHUHDVVHVVHGLQVLWXDQGFKDQJHVLQ WKHLU SKRVSKRU\ODWLRQ ZHUH TXDQWLᚏHG E\ ZHVWHUQ EORWWLQJ ([WUDFHOOXODU PDWUL[ DOWHUDWLRQVZHUHDVVHVVHGE\0DVVRQWULFKURPHVWDLQLQJ Results: :H GHPRQVWUDWHG WKDW ZLWK WKH DGYDQFHPHQW RI DJH FDYHUQRVDO UHPRGHOLQJZDVDᚎHFWHGE\DQDJHGHSHQGHQWXQEDODQFHEHWZHHQDSRSWRVLVDQG SUROLIHUDWLRQ7KLVWXUQRYHUDOWHUDWLRQZDVDFFRPSDQLHGE\VLJQLᚏFDQWPRGLᚏFDWLRQV LQWKHDFWLYDWLRQSURᚏOHRIWKHGRZQVWUHDPNLQDVHS,Q\RXQJHVWFDYHUQRVDO VDPSOHVSZDVPRVWO\DFWLYDWHGDWSHULYDVFXODUVLWHVQDPHO\LQFRUSRUHDO VPRRWKPXVFOHFHOOVPHGLDWLQJFHOOVXUYLYDOSUROLIHUDWLRQ+RZHYHULQWKHHOGHUO\ S SKRVSKRU\ODWLRQ VKLIWHG WR WUDEHFXODU ᚏEUREODVWV SURPRWLQJ H[WUDFHOOXODU PDWUL[SURGXFWLRQDQGGHSRVLWLRQ1RVLJQLᚏFDQWDOWHUDWLRQVZHUHREVHUYHGLQWKH FDYHUQRVDODFWLYDWLRQSDWWHUQRI$NWZLWKDJLQJ Conclusions: :HVKRZHGWKDWZLWKWKHDGYDQFHPHQWRIDJHWKHUHLVDQXQEDODQFH EHWZHHQ DSRSWRVLV DQG SUROLIHUDWLRQ LQ HUHFWLOH WLVVXH ,Q DGGLWLRQ ZH SURYLGHG HYLGHQFHIRUWKHᚏUVWWLPHWKDWLQDJLQJFDYHUQRVDOWLVVXH WKHGRZQVWUHDPDFWLYDWLRQ SURᚏOHRISNLQDVHLVDOWHUHGFRQWULEXWLQJWRSHQLOHFHOOXODUDQGPRUSKRORJLFDO FKDQJHVZKLFKDᚎHFWHUHFWLOHIXQFWLRQLQWKHHOGHUO\
72
TESTOSTERONE DEFICIENCY AND DECREASE OF LIBIDO IN OBSTRUCTIVE SLEEP APNEA SYNDROME (OSAS) PATIENTS
DQG%HFNVFRUHHVSHFLDOO\ZLWKTXHVWLRQUHIHUULQJWRLQWHUHVWLQVH[ S 7KHUHZDVDVLJQLᚏFDQWQHJDWLYHFRUUHODWLRQEHWZHHQWKHDPRXQWVRIWHVWRVWHURQH DQGGHJUHHRIK\SR[LD S! Conclusions: 2XUᚏQGLQJVVXJJHVWWKDWGHFUHDVHGOLELGRLVIUHTXHQWO\DVVRFLDWHG ZLWK REVWUXFWLYH VOHHS DSQHD V\QGURPH SUREDEO\ LQ FRUUHODWLRQ ZLWK ORZ VHUXP WHVWRVWHURQHOHYHODWWKRVHSDWLHQWV
73
WITHDRAWN
74
EFFECTS OF INDUCED HYPOGONADISM IN HUMAN CORPORA CAVERNOSA: AN IMMUNOHISTOCHEMICAL AND MORPHOMETRIC APPROACH
7RPDGD,7RPDGD11HYHV' 1 Faculty of Medicine of Universidade Do Porto, Laboratory For Molecular Cell Biology, Porto, Portugal, 2S. João Central Hospital, Dept. of Urology, Porto, Portugal Introduction & Objectives: $QGURJHQVDUHHVVHQWLDOIRUWKHQRUPDOGHYHORSPHQW RISHQLVDQGWKHLUGHᚏFLHQF\OHDGVWRLPSRUWDQWVWUXFWXUDODEQRUPDOLWLHV$OWKRXJK WKHLUH[DFWUROHLQKXPDQFRUSRUDFDYHUQRVD && LVVWLOOFRQWURYHUVLDOLWLVEHOLHYHG WKDWWKH\DUHFULWLFDOIRUHUHFWLOHIXQFWLRQZKLFKLQWXUQGHSHQGVIURPWLVVXHLQWHJULW\ DQG FHOOXODU YLDELOLW\ :H DLP WR FKDUDFWHUL]H \RXQJ KXPDQ && DIWHU LQGXFHG K\SRJRQDGLVP Material & Methods: $QGURJHQGHSULYHG SHQLOH IUDJPHQWV ZHUH UHPRYHG IURP LQGLYLGXDOV VXEPLWWHG WR PDOHWRIHPDOH VH[ UHDVVLJQPHQW SURFHGXUH Q \ ZKR XQGHUJRQH DQ DQGURJHQ GHSULYDWLRQ FKHPLFDO UHJLPHQ SURWRFRO PJGHVSLURQRODFWRQHDQGPJGF\SURWHURQHDFHWDWHIRUPRIROORZHGE\ PJG HVWUDGLRO IRU PR &RQWURO SHQLOH IUDJPHQWV ZHUH UHPRYHG IURP RUJDQ GRQRUV Q \ /RFDO FRPPLWWHH RQ HWKLFV DSSURYHG DQG DXWKRUL]HG WKH VWXG\7LVVXHIUDJPHQWVZHUHᚏ[HGSDUDᚑQHPEHGGHGDQGVWDLQHGZLWK0DVVRQಬV WULFKURPH7KHLPDJHVRIWLVVXHIUDJPHQWVVWDLQHGZLWK0DVVRQಬVWULFKURPHZHUH FDSWXUHGLQDQOLJKWPLFURVFRSHDQGVXEMHFWHGWRPRUSKRPHWULFDQDO\VLVRIVPRRWK PXVFOHDQGFRQQHFWLYHWLVVXHYROXPHWULFGHQVLWLHVHPSOR\LQJ,PDJH-pVRIWZDUH 7KHLPPXQRKLVWRFKHPLFDO DOSKDDFWLQYRQ:LOOHEUDQGIDFWRUದY:IದDQGYDVFXODU HQGRWKHOLDO JURZWK IDFWRU ದ9(*) DQG GXDOLPPXQRᚐXRUHVFHQFH VWXGLHV DOSKD DFWLQY:I DQG DOSKDDFWLQ9(*) ZDV DOVR SHUIRUPHG HPSOR\LQJ DSSURSULDWHG DQWLERGLHVDQGREVHUYHGLQDOLJKWRU$SRWRPHPLFURVFRSHVUHVSHFWLYHO\ Results: $QGURJHQGHSULYHGFDYHUQRXVWLVVXHLVVWUXFWXUDOO\GLᚎHUHQWIURPQRUPDO KRUPRQDO HQYLURQPHQW H[SRVHG WLVVXH &RPSDUDWLYHO\ WR FRQWUROV DQGURJHQ ZLWKGUDZDOOHDGVWRDVLJQLᚏFDQWGHFUHDVHLQVPRRWKPXVFOHFRQWHQW WR S DQGDVLJQLᚏFDQWLQFUHDVHLQFRQQHFWLYHWLVVXHGHQVLW\ WR S $GGLWLRQDOO\WKLVWLVVXHHYLGHQFHGDQHQODUJHPHQWRIYDVFXODUVSDFHV VXJJHVWLQJ WKDW DQGURJHQ GHSULYDWLRQ LQGXFHV YDVFXODU UHPRGHOOLQJ 2YHUDOO DV HUHFWLOHIXQFWLRQGHSHQGVRQVWUXFWXUDOLQWHJULW\RI&&WKHFKDQJHVREVHUYHGLQWKLV DQGURJHQGHᚏFLHQW&&PLJKWGHᚏQLWLYHO\FRPSURPLVHYDVRGLODWDWLRQ Conclusions: 2XUUHVXOWVXQGHUOLHWKHUROHRIDQGURJHQVLQVWUXFWXUDORUJDQL]DWLRQ RI&&DQGUHSUHVHQWQHZLQVLJKWVWRXQGHUVWDQGLQJHUHFWLOHIXQFWLRQPHFKDQLVPV LQ KXPDQ $OWKRXJK PROHFXODU VWXGLHV DUH SUHVHQWO\ XQGHU DQDO\VLV LQ RUGHU WR YDOLGDWH WKHVH ᚏQGLQJV ZH FRQVLGHU WKDW SHQLOH WLVVXH UHPRYHG IURP \RXQJ DQGURJHQGHSULYHGLQGLYLGXDOVLVQRWDQDGHTXDWHPRGHORIKHDOWK\&&
75
PROSTATE SAFETY OF TESTOSTERONE REPLACEMENT THERAPY IN MALE HYPOGONADISM: INTERIM RESULTS FROM THE LARGEST INTERNATIONAL TRIAL ON INJECTABLE LONG-ACTING TESTOSTERONE UNDECANOATE INVOLVING 763 PATIENTS
%HUFHD%6%HUFHD50&RMRFDUX(0LKDHVFX7 1 Clinical Hospital C.I. Parhon IASI, Dept. of Urology and Kidney Transplant, Iasi, Romania, 2Clinic of Pneumology, Dept. of Pneumology, Iasi, Romania, 3University of Medicine and Pharmacy “gr. T. Popa”, Dept. of Physiology, Iasi, Romania
=LW]PDQQ0+DQLVFK-80DWWHUQ$-XQJZLUWK$0DJJL0 1 University Clinics, Dept. of Reproductive Medicine and Andrology, Muenster, Germany, 2Bayer Vital GmbH, Male Health Care, Leverkusen, Germany, 3Bayer Schering Pharma, Dept. of Male Health Care, Berlin, Germany, 4EMCO Private Clinic, Dept. of Urology, Bad Dürrnberg, Austria, 5University of Florence, Dept. of Sexual Medicine and Andrology, Florence, Italy
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Eur Urol Suppl 2010;9(2):56