716. FIV Virus Mediated vIL-10 Gene Transfer Prolongs Cardiac Allograft Survival

    

    

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715. Imaging Adenoviral Mediated HSV1-sr39tk Reporter Gene Expression in Rat Myocardium with Immunohistochemistry Immunohistochemistry,, Autoradiography and MicroPET imaging Masayuki Inubushi,1 Joseph C. Wu,1,2 Simon Yee,1 Jorge Barrio,1 Nagichettiar Satyamurthy,1 Mohammad Namavari,1 Sanjiv S. Gambhir,1,2 Heinrich R. Schelbert.1 1 Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA, United States; 2Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA, United States. 56+                3  "8         -C(.8" =5/     

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716. FIV V irus Mediated vIL-10 Gene T ransfer Virus Transfer Prolongs Cardiac Allograft Survival Shuang Fu,1 Xia Mao,1 Dongmei Chen,1 Yaozhong Ding,1 Jonathan S. Bromberg.1,2 1 Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, United States; 2Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, United States. 2  7!  3    

           



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        Treatment untreated FIV-vIL-10 anti-CD40L mAb FIV-vIL-10 + anti-CD40L FTY720 FIV-vIL-10 + FTY720 anti-CD3 mAb FIV-vIL-10 + anti-CD3

n 4 4 4 4 5 4 4 6

Survival Time (days) 8, 10, 10, 12 18, 23, 23, 25 13, 13, 17, 17 23, 23, 31, 31 16, 19, 19, 23, 28 23, 26, 28, 34 25, 27, 30, 34 41, 41, 41, 50, 50, 50

Mean Survival p value 10±1.6 22.3±3 p<0.01 15±2.3 27±4.6 p<0.01 21±4.6 27.8±4.6 p<0.05 29±3.9 45.5±4.9 p<0.01

717. Complete Rescue of Lipoprotein Lipase-Deficient Mice by Gene T ransfer of the Naturally Occurring Transfer LPLS447X Beneficial Mutation Colin J. D. Ross,1 Guoqing Liu,1 Katherine J. D. AshbourneExcoffon,1 Jan Albert Kuivenhoven,2 John J. Kastelein,2 Suzanne M. E. Lewis,1 Michael R. Hayden.1 1 Medical Genetics, University of British Columbia, Vancouver, B.C., Canada; 2Department of Vascular Medicine, University of Amsterdam AMC, Amsterdam, Netherlands. D     -D!D/            - /"      C D!D                   "       D!D               6:         D!D "%"      -' /"



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Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy